DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20200384

Malignant transformation of ovarian mature teratoma: 04 cases report, review of the literature

Jihad Jamor, Alpha Boubacar Conte, Fatima Zohra Fdili Alaoui, Sofia Jayi, Hikmat Chaara, Moulay Abdelilah Melhouf

Abstract


Mature ovarian teratomas or dermoid cysts are the most common ovarian germinal tumors and account for 20 to 25% of ovarian organ tumors. The malignant transformation of a mature teratoma is a rare event (1 to 3%), mainly found in the post-menopausal period. This is carcinomatous degeneration (80% of cases) or sarcomatous differentiated tissues of the dermoid cyst. The diagnosis of certainty is established by anatomopathological study of the surgical piece. Treatment of carcinoma teratomas is surgical and same to ovarian malignant epithelial tumors. We report four cases we managed in our health care center with a review of the literature.


Keywords


Hassan II Teaching Hospital of Fès, Management, Mature teratoma, Malignant transformation, Ovarian cancer, Ovarian cysts

Full Text:

PDF

References


Romero R, Kalache KD, Kada N. Timing the Rha SE, Byun JY, Jung SE, et al. Atypical CT and MRI manifestations of mature ovarian cystic teratomas. AJR Am J Roentgenol. 2004;183(3):743-50.

Kim MJ, Kim NY, Lee DY, Yoon BK, Choi D. Clinical characteristics of ovarian teratoma: age-focused retrospective analysis of 580 cases. Am J Obstet Gynecol. 2011;205(1):32.e31-4.

Goudeli C, Varytimiadi A, Koufopoulos N, Syrios J, Terzakis E. An ovarian mature cystic teratoma evolving in squamous cell carcinoma: A case report and review of the literature. Gynecol Oncol Reports. 2017;19:27-30.

Hillard PJ. Benign diseases of the female reproductive tract. In: Berek JS, Novak E, editors. Berek and Novak’s gynecology. 14th ed. Philadelphia, PA: Lippincott Willians and Wilkins; 2007:431-504.

Hackethal A, Brueggmann D, Bohlmann MK, Franke FE, Tinneberg HR, Münstedt K. Squamous-cell carcinoma in mature cystic teratoma of the ovary: systematic review and analysis of published data. Lancet Oncol. 2008;9:1173-80.

Jitsumori M, Munakata S, Yamamoto T. Malignant transformation of mature cystic teratoma diagnosed after a 10-year interval. Hindawi Case Reports Obstet Gynecol. 2017:Article ID 2947927.

Park SB, Kim JK, Kim KR, Cho KS. Imaging findings of complications and unusual manifestations of ovarian teratomas. Radiograph. 2008;28:969-83.

Park SB, Kim JK, Kim KR, Cho KS. Preoperative diagnosis of mature cystic teratoma with malignant transformation: analysis of imaging findings and clinical and laboratory data. Arch Gynecol Obstet. 2007;275:25-31.

Lai PF, Hsieh SC, Chien JC, Fang CL, Chan WP, Yu C. Malignant transformation of an ovarian mature cystic teratoma: computed tomography findings. Arch Gynecol Obstet. 2005;271:355-7.

Fujimura M. Mature cystic teratoma. Kanto San Fu Shi. 2012;49:655-7.

Hurwitz JL, Fenton A, McCluggage WG, McKenna S. Squamous cell carcinoma arising in a dermoid cyst of the ovary: a case series. Int J Obstet Gynaecol. 2007;114(10):1283-7.

Esterson YB, Gaballah M, Grimaldi GM, Raj MH, Pellerito JS. Ovarian dermoid cyst complicated by small bowel obstruction, entero-ovarian fistula formation, and malignant degeneration. Clin Imag. 2019;56:47-51.

Rim SY, Kim SM, Choi HS. Malignant transformation of ovarian mature cystic teratomas. Int J Gynecol Cancer. 2006;16:140-4.

Chen E, Fletcher CD, Nucci MR. Meningothelial proliferations in mature cystic teratoma of the ovary: evidence for the common presence of cranially derived tissues paralleling anterior embryonic plate development. An analysis of 25 consecutive cases Am J Surg Pathol. 2010;34 (7):1014-8.

Chiang AJ, Chen MY, Weng CS, Lin H, Lu CH, Wang PH, et al. Malignant transformation of ovarian mature cystic teratoma into squamous cell carcinoma: a Taiwanese Gynecologic Oncology Group (TGOG) study. J Gynecol Oncol. 2017;28(5).

Argoitia X, Duga I, Labeyrie E, Toledo L, Couteau C, Querleu D. Dégénérescence des kystes dermoïdes. À propos d’un cas de transformation maligne. Gynecol Obstet Fertil. 2007;35:1005-8.

Desouki MM, Fadare O, Chamberlain BK, Shakir N, Kanbour-Shakir A. Malignancy associated with ovarian teratomas: frequency, histotypes, and diagnostic accuracy of intraoperative consultation. Ann Diagn Pathol. 2015;19:103-6.

Yamanaka Y, Tateiwa Y, Miyamoto H, Umemoto Y, Takeuchi Y, Katayama K, et al. Preoperative diagnosis of malignant transformation in mature cystic teratoma of the ovary. Eur J Gynaecol Oncol. 2005;26:391-2.

Park SB, Cho KS, Kim JK. CT findings of mature cystic teratoma with malignant transformation: comparison with mature cystic teratoma. Clin Imag. 2011;35(4):294-300.

Maamar M, Tazi-Mezalek Z, Harmouche H. Kyste dermoide cancérisé de l'ovaire: à propos d'un cas. La presse médicale février. 2013;42(2):232-5.

Caspi B, Appelman Z, Rabinerson D, Zalel Y, Tulandi T, Shoham Z. The growth pattern of ovarian dermoid cyst: a prospective study in premenopausal and postmenopausal women. Fertil Steril. 1997;68(3):501-5.

Suzuki M, Takashima T, Itoh H, Choutoh S, Kawamura I, Watanabe Y. Computed tomography of mediastinal teratomas. JCAT. 1983;7:74-6.

Emoto M, Obama H, Horiuchi S, Miyakawa T, Kawarabayashi T. Transvaginal color Doppler ultrasonic characterization of benign and malignant ovarian cystic teratomas and comparison with serum squamous cell carcinoma antigen. Cancer. 2000;88(10):2298-304.

Mori Y, Nishii H, Takabe K, Shinozaki H, Matsumoto N, Suzuki K, et al. Preoperative diagnosis of malignant transformation arising from mature cystic teratomas of the ovary. Gynecol Oncol. 2003;90:338-41.

Umemoto M, Shiota M, Shimono T, Hoshiai H. Preoperative diagnosis of ovarian tumors, focusing on the solid area based on diagnostic imaging. J Obstet Gynaecol Res. 2006;32:195e201.

Mayer C, Miller DM, Ehlen TG. Peritoneal implantation of squamous cell carcinoma following rupture of a dermoid cyst during laparoscopic removal. Gynecol Oncol. 2002;84:180-3.

Wen KC, Hu WM, Twu NF, Chen P, Wang PH. Poor prognosis of intraoperative rupture of mature cystic teratoma with malignant transformation. Taiwan J Obstet Gynecol. 2006;45:253-6.

Li C, Zhang Q, Zhang S, Dong R, Sun C, Qiu C, et al. Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review. BMC Cancer. 2019;19:217.

Dos Santos L, Mok E, Iasonos A, Park K, Soslow RA, Aghajanian C, et al. Squamous cell carcinoma arising in mature cystic teratoma of the ovary: a case series and review of the literature. Gynecol Oncol 2007;105:321-4.

Chbani L, Znati K, El Fatemi H, Harmouch T, Bouchikhi C, Bennis S, et al. Transformation maligne épithéliale d’un tératome mature de l’ovaire: à propos d’un cas. Revue Francophone des Laboratoires. 2008;2008(407):99-102.

Safini F, Bouchbika Z, Bouanani R, Mernissi F, Wilfried A, Benchakroun N, et al. Carcinome épidermoïde sur tératome mature de l’ovaire: à propos de deux cas. Revue Francophone des Laboratoires. 2017;489(2017):103-6.