Feto-maternal outcome in human immunodeficiency virus seropositive mothers in co-relation with CD4 count


  • Swati Trivedi Department of Obstetrics and Gynecology, S. M. S. Medical College, Jaipur, Rajasthan, India
  • Oby Nagar Department of Obstetrics and Gynecology, S. M. S. Medical College, Jaipur, Rajasthan, India
  • Prasoon Rastogi Department of Medicine, King George Medical University, Lucknow, Uttar Pradesh, India
  • Manish Bhardwaj Department of Obstetrics and Gynecology, S. M. S. Medical College, Jaipur, Rajasthan, India




Adverse foetal outcomes, CD4 count, Human immunodeficiency virus, Mother to child transmission


Background: To study the effect of human immunodeficiency virus (HIV) infection on pregnancy outcomes and new born as mother to child transmission of HIV is a major route on new infections in children and compare it with HIV uninfected pregnancies.

Methods: Prospective comparative study conducted on 40 HIV seropositive and 40 HIV seronegative pregnant women attending ANC and delivering in the department of obstetrics and gynecology, S. M. S. Medical College, Jaipur, Rajasthan, India.

Results: CD4 count had no effect on birth weight of baby or term of delivery. HIV seropositive pregnancies were more prone to IUD, still birth and preterm birth (p=0.029). Mother to child transmission was 2.7%.

Conclusions: HIV infection increases the risk of adverse foetal outcome in terms of intrauterine demise, still birth and preterm labour.


Summary of the Global HIV epidemic WHO: global situation and trends, 2018. Available at: https://www.who.int/gho/hiv/en/. Accessed on 4th January 2020.

NACO (National AIDS Control Organization) Annual Report NACO 2016-17 English. Available at: http://naco.gov.in/documents/annual-reports. Accessed on 4th January 2020.

HIV Facts and figures: NACO, Available at: http://naco.gov.in/hiv-facts-figures. Accessed on 4th January 2020.

National AIDS Control Organization Ministry of Health and Family Welfare Government of India: National Technical Guidelines on Anti-Retroviral Treatment. Chapter 7; 2018:50-59.

Newell ML, Peckham CS, Lepage P. HIV-I infection in pregnancy: implications for women and children. AIDS. 1990;4 (suppl 1):S111-S117.

Delfraissy JF, Blanche S, Rouzioux C, Mayaux MJ. Perinatal HIV transmission facts and controversies. Immunodefic Rev 1992;3305-27.

Brettle RP, Leen CL. The natural history of HIV and AIDS in women. AIDS. 1991;5:1283-92.

Johnstone FD, MacCallum L, Brettle R, Inglis JM, Peutherer JF. Does infection with HIV affect the outcome of pregnancy? Br Med J Clin Res Ed. 1988;296:467.

Schulte J, Dominguez K, Sukalac T, Bohannon B, Fowler MG. Declines in low birth weight and preterm birth among infants who were born to HIV-infected women during an era of increased use of maternal antiretroviral drugs: Pediatric Spectrum of HIV Disease, 1989-2004. Pediatr. 2007;119:e900-e906.

Dadhwal V, Sharma A, Khoiwal K, Deka D, Sarkar P, Vanamail P. Pregnancy outcomes in hiv-infected women: experience from a tertiary care center in India. Inter J MCH AIDS. 2017;6(1):75-81.

Brocklehurst P, French R. The association between maternal HIV infection and perinatal outcome: a systemic review of the literature and meta-analysis. Br J Obstet Gynecol. 1998;105:839-48.

Xiao PL, Zhou YB, Chen Y, Yang MX, Song XX, Shi Y, et al. Association between maternal HIV infection and low birth weight and prematurity: a meta-analysis of cohort studies. BMC Preg Childbirth. 2015;15:246.

Habib N, Dalteveit T. Maternal HIV status and pregnancy outcomes in north eastern Tanzania: a registry-based study. Br J Obstet Gynecol. 2008;115:616-24.

Prameela RC, Asha MB, Bhanumathi, Geetha T, Vasumathy S, Shankar R. Maternal and fetal outcome in hiv pregnant women, 5 years study at tertiary hospital. IOSR J Dent Med Sci. 2015;14(3):53-6.

Malik A, Sami H, Khan PA, Fatima N, Siddiqui M. Prevalence of human immunodeficiency virus infection in Pregnant women and birth outcome at tertiary care centre in a North Indian Town. J Immunol Vaccine Technol. 2015;1(1):104.

Ezechi OC, Gab Okafor CV, Oladele DA, Kalejaiye OO, Oke BO, Ohowodo HO, et al. Pregnancy, obstetrics and neonatal outcomes in HIV positive Nigerian women. Afr J Reprod Health. 2013;17(3):160-8.

Yudin MH, Caprara D, MacGillivray SJ, Urquia M, Shah RR. A ten-year review of antenatal complications and pregnancy outcomes among HIV-positive pregnant women. J Obstet Gynaecol Can. 2016;38(1):35-40.

Dwivedi S, Jahan U, Dwivedi GN, Gupta N, Verma K, Sharma B, ET AL. Perinatal outcome in HIV infected pregnant women at tertiary care Hospital in North India: eleven years retrospective study. Inter J Recent Sci Res. 2017;8(5):16801-5.

Van der Merwe K, Hoffman R, Black V. Birth outcomes in South African women receiving highly active antiretroviral therapy: a retrospective observational study. J Int AIDS Soc. 2011;14(1):42.

Kim HY, Kasonde P, Mwiya M. Pregnancy loss and role of infant HIV status on perinatal mortality among HIV-infected women. BMC Pediatr. 2012;12:138.

Kennedy D. The effect of maternal HIV status on perinatal outcome at Mowbray Maternity Hospital and referring midwife obstetric units, Cape Town. SAJOG. 2012;18(1):6-10.

Kumar RM, Uduman SA, Khurrana AK. Impact of maternal HIV-1 infection on perinatal outcome. Int J Gynaecol Obstet. 1995;49:37-143.

Ellis J, Williams H, Graves W. Human immunodeficiency virus infection is a risk factor for adverse perinatal outcome. Am J Obstet Gynecol. 2002;186:903-6.

Gautam S, Shah T. Study of perinatal outcome in human immunodeficiency virus positive women. Int J Reprod Contracept Obstet Gynecol. 2016;5(8):2587-90.

Yadav S, Joshi R, Kale V. Study of factors affecting maternal and fetal outcome in HIV positive women. Int J Reprod Contracept Obstet Gynecol. 2017;6(1):256-261.

Azria E, Mountaoff C, Schmitz T, Le Meaux JP. Pregnancy outcomes in women with hiv type 1 receiving a lopinavir/ ritonavir containing regimen. Int Med Press. 2014;14:423-32.

Palombi L, Marazzi MC, Voetberg A, Magid NA. Treatment acceleration program and the experience of the DREAM program in prevention of mother-to-child-transmission of HIV. AIDS. 2007;21Suppl4:S65-71.

Saharan S, Lodha R, Agarwal R, Deorari AK, Paul VK. Perinatal HIV. The Indian J Pediatr. 2008;75(4):359-62.

Malpani P, Biswas M, Kale V. Outcome of children born to human immunodeficiency virus positive mothers- a retrospective study. Indian J Child Health. 2016;3(3):244-7.






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