Successful pregnancy outcome in a patient of chronic myeloid leukemia on imatinib therapy

Authors

  • Manisha Singhal Department of Obstetrics and Gynaecology, S.M.S. Medical College, Jaipur, Rajasthan, India
  • Khushbu Meena Department of Obstetrics and Gynaecology, S.M.S. Medical College, Jaipur, Rajasthan, India
  • Neelam Bharadwaj Department of Obstetrics and Gynaecology, S.M.S. Medical College, Jaipur, Rajasthan, India
  • Renuka Mundaliya Department of Obstetrics and Gynaecology, S.M.S. Medical College, Jaipur, Rajasthan, India
  • Shruti Agarwal Department of Obstetrics and Gynaecology, S.M.S. Medical College, Jaipur, Rajasthan, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20160611

Keywords:

CML in pregnancy, Imatinib in pregnancy, Safety of imatinib

Abstract

Pregnancy and cancer is a complex situation. The coincidence chronic myeloid leukemia (CML) and pregnancy is an uncommon event, in part because CML occurs mostly in older age group. The management of CML, during pregnancy is a difficult problem because of potential effects of therapy on the mother and foetus. Imatinib, a tyrosine kinase inhibitor induces dramatic hematologic and cytogenetic responses in CML, but it is not recommended for use in pregnancy or if the patient plans to conceive. In literature there are very few reports of successful outcome of pregnancy while on imatinib. In this report we describe a successful pregnancy and labor under treatment with imatinib in a known case of CML.

 

References

Peleg D, Ben-Ami M Lymphoma and leukemia complicating pregnancy. Obstet gynecol clin North Am. 1998;25:365-81.

Buekers TE, Lallas TA. Chemotherapy in pregnancy. Obstetgynecolclin North Am. 1998;25:323-9.

Ali R, Ozkalemkas F, Ozcelik T. Pregnancy under treatment of imatinib and successful labor in a patient with chronic myelogenous leukemia (CML). Outcome of discontinuation of imatinib therapy after achieving a molecular remission. Leuk Res. 2005;29(8):971-73.

Prabhash K, Sastry PS, Biswas G. Pregnancy outcome of two patients treated with imatinib. Ann Oncol. 2005;12:1983-4.

Thauvin-Robinet C, Maingueneau C, Robert E, Elefant E, Guy H, Caillot D. Exposure to hydroxyurea during pregnancy: a case series. Leukemia. 2001;15:1309-11.

Rizack T, Mega A, Legare R, Castillo J. Management of haematological Malignancies during pregnancy. Am J Hematol. 2009;84:830-41.

Russell MA, Carpenter MW, Akhtar MS, Lagattuta TF, Egorin MJ. Imatinibmesylate and metabolite concentrations in maternal blood, umbilical cordblood, placenta and breast milk. J Perinatol. 2007;27:241-3.

Shapira T, Pereg D, Lishner M. How I treat acute and chronic leukemia in Pregnancy. Blood Rev. 2008;22:247-59.

Downloads

Published

2017-02-23

Issue

Vol. 5 No. 3 (2016): March 2016

Section

Case Reports