Uterine smooth muscle tumor of uncertain malignant potential: a case diagnosis, management and follow-up in the department of gynecology-obstetrics II of the Hassan II teaching hospital of Fes in Morocco

Alpha Boubacar Conte, Jihad Jamor, Fatima Zohra Fdili Alaoui, Sofia Jayi, Hikmat Chaara, Moulay Abdelilah Melhouf


Rarely diagnosed in authors department, uterine smooth muscle tumor of uncertain malignant potential (STUMP) is one of the histologic types of uterine sarcoma. Among women undergoing hysterectomy or myomectomy for a presumed diagnosis of leiomyoma, 0.01% receive a diagnosis of STUMP. Authors report a case occurring to a patient aged of 55 which was diagnosed, managed successfully and followed-up in authors department.


Follow up, Management, Sarcoma, Smooth muscle tumor of uncertain malignant, Uterine tumors

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Tavassoli FA, Devilee P. World Health Organization classification of tumours: tumours of the breast and female genital organs. Lyon: Inter Agency Res Cancer Press; 2003:236-9.

Picerno TM, Wasson MN, Gonzalez Rios A and al. Morcellation and the incidence of occult uterine malignancy: a dual-institution review. Int J Gynecol Cancer. 2016;26(1):149-55.

Stewart EA, Quade BJ, Laughlin - Tommaso SK. Variants of uterine leimyomas (fibroids), 2017. Available at: Accessed on 12th December 2019.

Berretta R, Rolla M, Merisio C, Giordano G, Nardelli GB. Uterine smooth muscle tumor of uncertain malignant potential: a three-case report. Int J Gynecol Cancer. 2008;18:1121-6.

Guntupalli SR, Ramirez PT, Anderson ML, Milam MR, Bodurka DC, Malpica A. Uterine smooth muscle tumor of uncertain malignant potential: a retrospective analysis. Gynecol Oncol. 2009;113:324-6.

Bacanakgil BH, Deveci M, Karabuk E, Soyman Z. Uterine smooth muscle tumor of uncertain malignant potential: clinicopathologic- sonographic characteristics, follow-up and recurrence. World J Oncol. 2017;8(3):76-80.

D’all Asta A, Gizzo S, Musaro A, Quaranta M. Uterine smooth muscle tumors of uncertain malignant potential (STUMP): pathology, follow-up and recurrence. Inter J Clin Experiment Pathol. 2014;7(11):8136-42.

Hughes L, Roex A, Parange A. STUMP, a surprise finding in a large fibroid uterus in a 20-year-old woman. Inter J Women’s Health. 2018;10:211-4.

Schwartz LB, Zawin M, Carcangiu ML, Lange R, McCarthy S. Does pelvic magnetic resonance imaging differentiate among the histologic subtypes of uterine leiomyomata? Fertil Steril. 1998;70(3):580-7.

Shapiro A, Ferenczy A, Turcotte R, Bruchim I, Gotlieb WH. Uterine smooth-muscle tumor of uncertain malignant potential metastasizing to the humerus as a high-grade leiomyosarcoma. Gynecol Oncol. 2004;94:818-20.

Bell SW, Kempson RL, Hendrickson MR. Problematic uterine smooth muscle neoplasms. A clinicopathologic study of 213 cases. Am J Surg Pathol. 1994;18(6):535-58.

Ip PP, Tse KY, Tam KF. Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: a review of selected variants with emphasis on recent advances and unusual morphology that may cause concern for malignancy. Adv Anat Pathol. 2010;17(2):91-112.

Oliva E. Cellular mesenchymal tumors of the uterus: A review emphasizing recent observations. Int J Gynecol Pathol. 2014;33:374-84.

Duvillard P. Pathologie gynécologique; cas N°7. Tumeur musculaire lisse utérine de malignité incertaine (STUMP), Annales de Pathol. 2012;32:211-3.