Vitamin D deficiency and its correlation with pregnancy outcome


  • Maya Menon Department of Obstetrics and Gynecology, ESIC Medical College and PGIMSR, K. K. Nagar, Chennai, Tamil Nadu, India
  • Sridevi T. A. Department of Obstetrics and Gynecology, ESIC Medical College and PGIMSR, K. K. Nagar, Chennai, Tamil Nadu, India
  • Thuthi Mohan Department of Biochemistry, ESIC Medical College and PGIMSR, K. K. Nagar, Chennai, Tamil Nadu, India
  • Aruna B. Patil Department of Community Medicine, ESIC Medical College and PGIMSR, K. K. Nagar, Chennai, Tamil Nadu, India



Fetal outcome, Maternal outcome, Vitamin D deficiency


Background: There is a growing concern about the high prevalence of vitamin D deficiency and its relationship with variety of diseases worldwide. The objective of this study was to determine the prevalence of vitamin D deficiency and its association with pregnancy outcome.

Methods: This was a cross sectional study conducted among 150 antenatal women from October 2014 to April 2015. Data containing socio-demographic details, vitamin D level, serum calcium, pregnancy complications and growth situation of newborns were collected and analyzed.

Results: A total 150 pregnant women participated in the study, 75.3% were vitamin D deficient, 22.1% vitamin D insufficient and 2.6% normal. There was no significant adverse maternal outcome. NICU admission was required in 28.3 and 15.2% in the vitamin D deficient and insufficient groups respectively.

Conclusions: Women from different socioeconomic status, irrespective of parity and educational levels had vitamin D deficiency and insufficiency. This study fails to show a relation of vitamin D deficiency with other high-risk factors of pregnancy and does not show any adverse fetal outcome.


Prasad D, Smita, Singh K, Nisha S. Vitamin D in pregnancy and its correlation with feto maternal outcome. Inter J Cont Med Res. 2018;5(1):1-5.

Dave A, Verma M, Jain N. A study of vitamin D levels and associated deficiency in pregnancy and its effect on maternal and fetal outcome. Inter J Reprod Contracept Obstet Gynecol. 2017;6(1):84-8.

Merewood A, Mehta SD, Chen TC, Baucher H. Association between vitamin D deficiency and primary cesarean section. J Clin Endocrinol Metab. 2009;94(3):940-5.

Ates S, Sevket O, Ozcan P, Ozkal F. Vitamin D status in the first trimester: effects of vitamin D deficiency on pregnancy outcomes. Afri Health Sci. 2016;16(1):36-43.

Gupta M, Debnath A, Jain S, Saini V. Vitamin D status in pregnancy: fetomaternal outcome and correlation with cord blood vitamin D. Indian J Med Biochem. 2017;21(1):42-8.

Chen YH, Fu L, Hao JH, Wang H. Influent factors of gestational vitamin D deficiency and its relation to an increased risk of preterm delivery in Chinese population. Scientific Reports. 2018;8:3608.

Bener A, Al-Hamaq AO, Saleh NM. Association between vitamin D insufficiency and adverse pregnancy outcome: global comparisons. Inter J Womens Health. 2013;5:523-31.

Ghadeer K, Shaikh A, Ibrahim GH. Impact of vitamin D deficiency on maternal and birth outcomes in the Saudi population: a cross sectional study. BioMed Central Preg Childbirth. 2016;16:119.

Chakhtoura M, Nassar A, Arabi A, Cooper C. Effect of vitamin D replacement on maternal and neonatal outcomes: a randomized controlled trial in pregnant women with hypovitaminosis D. BMJ Open. 2016;6:e010818.

Movahedian A, Ghomian N, Soltani S. A review of the literature on the association between vitamin D status and the risk of pre-eclampsia. Rev Clin Med. 2015;2(1):15-8.

Pirdehghan A, Vakili M, Dehghan R. High prevalence of vitamin D deficiency and adverse pregnancy outcomes in Yazd, a central province of Iran. J Reprod Infertil. 2016;17(1):34-8.

Kaushal M, Magon N. Vitamin D in pregnancy: a metabolic outlook. Indian J Endocr Metab. 2013;17:76-82.

Sharma S, Kumar A, Prasad S. Current scenario of vitamin D status during pregnancy in North India population. J Obstet Gynecol India. 2016;66(2):93-100.

Gupta DA, Saikia UK, Sarma D. Status of 25(OH)D level in pregnancy: a study from North eastern part of India. Indian J Endocrinol Metab. 2012;16(Suppl 2):S405-S407.

Bodnar LM, Catov JM, Simhan HN. Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab. 2007;92:3517-22.

Shand AW, Nassar N, Von Dadelszen P. Maternal vitamin D status D deficiency increases the risk of preeclampsia. BJOG. 2010;117(13):1593-8.

Parlea L, Bromberg IL, Feig DS, Vieth R. Association between serum 25-hydroxyvitamin D in early pregnancy and risk of gestational diabetes mellitus. Diabet Med. 2012;29:e25-e32.

Kazemi A, Sharifii F, Jafari N, Mousavinasab N. High prevalence of vitamin D among pregnant women and their newborn in an Iranian population. J womens Health (Larchmt). 2009;18:835-9.

Scholl TO, Chen X. Vitamin D intake during pregnancy. Association with maternal characteristics and infant birth weight. Early Hum Dev. 2009;85:231-4.






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