Ectopic ovarian pregnancy following in vitro fertilization: case report


  • Shrinkhla Khandelwal Department of Obstetrics and Gynecology, Sri Aurobindo Institute of Medical Sciences, Indore, Madhya Pradesh, India
  • Neeta Natu Department of Obstetrics and Gynecology, Sri Aurobindo Institute of Medical Sciences, Indore, Madhya Pradesh, India



Ectopic pregnancy, Ovarian pregnancy


Ovarian pregnancy is a rare form of extrauterine ectopic pregnancy. Risk factors such as reproductive treatments and infertility have been identified in recent studies. In this article, we present a case of ovarian ectopic pregnancy occurring following in vitro fertilization treatment and a fresh embryo transfer. The diagnosis of ovarian pregnancy was made during transvaginal sonography performed due to suspected ectopic pregnancy. Ovarian ectopic pregnancy is a rare clinical phenomenon. Late diagnosis and lack of appropriate intervention may have catastrophic results. Several mechanisms and risk factors are proposed, and their acknowledgment may improve early diagnosis and prevention of complications.


Raziel A, Golan A, Pansky M. Ovarian pregnancy: a report of twenty cases in one institution. Am J Obstet Gynecol. 1990;163:1182-5.

Marcus SF, Brinsden PR. Analysis of the incidence and risk factors associated with ectopic pregnancy following in-vitro fertilization and embryo transfer. Human Reprod. 1995;10(1):199-203.

Marcus SF, Brinsden PR. Primary ovarian pregnancy after in vitro fertilization and embryo transfer: report of seven cases. Fertil Steril. 1993;60(1):167-9.

Ishikawa H, Sanada M, Shozu M. Ovarian pregnancy associated with a fresh blastocyst transfer following. J Obstet Gynaecol Res. 2015;41(11):1823-5.

Andrade AG, Rocha S, Marques CO. Ovarian ectopic pregnancy in adolescence. Clin Case Rep. 2015;3(11):912-5.

Samara N, Bentov Y. Case report of ectopic ovarian pregnancy following fresh embryo transfer. Clin Med Insights Reprod Health. 2016;10:29-32.

Spiegelberg O. Zur casusistik der ovarial schwangerschaft. Arch Gynaekal. 1978;13:73-39.

Choi HJ, Im KS, Jung HJ, Lim KT, Mok JE, Kwon YS. Clinical analysis of ovarian pregnancy: a report of 49 cases. Eur J Obstet Gynecol Reprod Biol. 2011;158(1):87-9.

Kashima K, Yahata T, Yamaguchi M, Fujita K, Tanaka K. Ovarian pregnancy resulting from cryopreserved blastocyst transfer. J Obstet Gynaecol Res. 2013;39(1):375-7.

Huang B, Hu D, Qian K, Ai J, Li Y, Jin L, et al. Is frozen embryo transfer cycle associated with a significantly lower incidence of ectopic pregnancy? An analysis of more than 30,000 cycles. Fertil Steril. 2014;102(5):1345-9.

Shapiro BS, Daneshmand ST, De Leon L, Garner FC, Aguirre M, Hudson C. Frozen-thawed embryo transfer is associated with a significantly reduced incidence of ectopic pregnancy. Fertil Steril. 2012;98(6):1490-4.

Ishihara O, Kuwahara A, Saitoh H. Frozen-thawed blastocyst transfer reduces ectopic pregnancy risk: an analysis of single embryo transfer cycles in Japan. Fertil Steril. 2011;95(6):1966-9.

Bu Z, Xiong Y, Wang K, Sun Y. Risk factors for ectopic pregnancy in assisted reproductive technology: a 6-year, single-center study. Fertil Steril. 2016;106(1):90-4.

Atabekoglu CS, Berker B, Dunder I. Ovarian ectopic pregnancy after intracytoplasmic sperm injection. Eur J Obstet Gynecol Reprod Biol. 2004;112(1):104-6.

Wang J, Wei Y, Diao F, Cui Y, Mao Y, Wang W, et al. The association between polycystic ovary syndrome and ectopic pregnancy after in vitro fertilization and embryo transfer. Am J Obstet Gynecol. 2013;209(2):139.e1-9.

Practice Committee of American Society for Reproductive Medicine. Medical treatment of ectopic pregnancy. Fertil Steril. 2006;86(5 suppl 1):S96-S102.

Kudo M, Tanaka T, Fujimoto S. A successful treatment of left ovarian pregnancy with methotrexate. Nippon Sanka Fujinka Gakkai Zasshi. 1988;40:811-3.

Shamma FN, Schwartz LB. Primary ovarian pregnancy successfully treated with methotrexate. Am J Obstet Gynecol. 1992;167:1307-8.






Case Reports