Use of vaginal misoprostol before endometrial biopsy in premenopausal women: an observational study


  • Prabhavathi V. Department of Obstetrics and Gynecology, NRI Institute of Medical Sciences, Sangivalasa, Visakhapatnam, India
  • Prasad D. K. V. Department of Biochemistry, NRI Institute of Medical Sciences, Sangivalasa, Visakhapatnam, India
  • Lahari N. Department of Obstetrics and Gynecology, NRI Institute of Medical Sciences, Sangivalasa, Visakhapatnam, India
  • Satyavathi R. Department of Obstetrics and Gynecology, NRI Institute of Medical Sciences, Sangivalasa, Visakhapatnam, India



Cervical injury, Cervical ripening, Endometrial biopsy, Prostaglandin E1, Visual analog scale score


Background: It is well-known since long time the beneficial effects of misoprostol particularly as a cervical softening agent in obstetric practice. Keep in view, study aimed to evaluate the efficacy of vaginal misoprostol 400 mcg before endometrial biopsy in premenopausal women.

Methods: All the 200 patients were classified into two groups viz. study group (Group I) with 100 patients and control group (Group II) with 100 patients. To Group I patients, 400 mcg of misoprostol was given vaginally, 4 hours prior to the commencement of endometrial biopsy whereas no medication was received by Group II patients.

Results: In the present study, the base line cervical dilatation is found to be 5.8±1.3 mm in Group I patients whereas 3.8±0.92 mm in Group II patients which is significantly higher (p<0.05). Only 32 patients in Group I required further dilatation whereas 88 patients in Group II underwent further dilatation. The mean time required for further dilatation in Group I and Group II patients was 42.6±17.4, 64.6±16.8 sec respectively and was significantly higher in Group II patients (p<0.05). Out of 100 patients in Group I, only 2% of patients complained severe pain whereas in Group II 48% of patients experienced intolerable pain and required anesthesia.

Conclusions: Vaginal administration of 400 mcg misoprostol 4 hours prior to endometrial biopsy in premenopausal women had a significant effect on cervical resistance and cervical dilatation.


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