DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20202360

Sex cord stromal tumor of ovary masquerading as polycystic ovarian syndrome

Manisha Jhirwal, Shashank Shekhar, Charu Sharma, Apoorva Tak

Abstract


Virilization is a portentous sign that suggests the possibility of an ovarian or adrenal neoplasm. Diagnosis may be delayed in some patients due to nonspecific symptoms and overlapping symptoms with that of polycystic ovarian syndrome (PCOS). However, it must be remembered that PCOS usually causes mild to moderate elevation of serum testosterone with hirsutism whereas serum testosterone levels are many times elevated in cases of androgen secreting tumors and virilization is a norm. So high testosterone level with new onset virilization rule out PCOS. Authors are reporting two cases of Sertoli Leydig cell tumor despite their similar histopathology and equivalent levels of serum testosterone had a varied clinical spectrum of virilization.


Keywords


Hirsutism, Ovarian neoplasm, Polycystic ovarian syndrome, Sertoli Leydig cell tumor, Virilization

Full Text:

PDF

References


Nam SM, Kim JW, Eoh KJ, Kim HM, Lee JY, Nam EJ, et al. A Novel clinicopathological analysis of early stage ovarian Sertoli Leydig cell tumors at a single institution. Obstet Gynecol Sci. 2017;60(1):39-45.

Conway G, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Franks S, Gambineri A, et al. The polycystic ovary syndrome: a position statement from the European Society of endocrinology. Eu J Endocrinol. 2014;171(4):P1-29.

Sarfati J, Bachelot A, Coussieu C, Meduri G, Touraine P. Study group hyperandrogenism in postmenopausal women. Impact of clinical, hormonal, radiological, and immunohistochemical studies on the diagnosis of postmenopausal hyperandrogenism. Eur J Endocrinol. 2011;165:779-88.

Oliva E, Alvarez T, Young RH. Sertoli cell tumors of the ovary: a clinicopathological and immunohistochemical study of 54 cases. Am J Surg Pathol. 2005;29:143-56.