A rare case of Crigler-Najjar syndrome type II with pregnancy

Authors

  • Rachna Chaudhary Department of Obstetrics and Gynecology, LLRM Medical College, Meerut, UP, India
  • Amit Maheshwari Department of Medicine, LLRM Medical College, Meerut, UP, India
  • . Deepmala Department of Obstetrics and Gynecology, LLRM Medical College, Meerut, UP, India
  • Virendra Tapparwal Department of Pathology, LLRM Medical College, Meerut, UP, India

Keywords:

Pregnancy, Hyperbilirubinemia

Abstract

Crigler-Najjar syndrome (CNS) has been rarely described during pregnancy with only few case reports available in literature, CNS is expressed in two forms, CNS type I and CNS type II; Type I CNS results in severe unconjugated hyperbilirubinemia and neurological impairment in newborn and is fatal. Type II CNS results in milder unconjugated hyperbilirubinemia responding to Phenobarbital treatment with better outcome.

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References

Passuello V, Puhl AG, Wirth S, Steiner E, Skala C, Koelbl H, Kohlschmidt N. Pregnancy outcome in maternal Crigler-Najjar syndrome type II: a case report and systematic review of the literature. Fetal Diagn Ther. 2009;26(3):121-6.

Arora N, Chaudhary S. Pregnancy with Crigler-Najjar syndrome type-II, J Obstet Gynecol 2009;29:242-4.

Holstein A, Plaschke A, Lohse P, Egberts EH. Successful Photo and Phenobarbital therapy during pregnancy in a woman with Crigler–Najjar syndrome type-II. Scand J Gasgroenterol 2005;40:1124-6.

Smith JF, Baker JM. Crigler-Najjar disease in pregnancy. Obstet Gynecol 1194;84:670-2.

Shakuntala PN, Poornima M, Padmalatha VV, Rao SR. Successful pregnancy outcome in maternal Crigler-Najjar syndrome type-II. Online J Health Allied Scs 2012;11(3):12.

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Published

2016-12-24

How to Cite

Chaudhary, R., Maheshwari, A., Deepmala, ., & Tapparwal, V. (2016). A rare case of Crigler-Najjar syndrome type II with pregnancy. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 3(1), 261–262. Retrieved from https://www.ijrcog.org/index.php/ijrcog/article/view/837