Role of lipid profile and uterine artery doppler in predicting risk of preeclampsia in early second trimester


  • Sheena Chopra Department of Obstetrics and Gynecology, Sri Guru Ram Das Institute of Medical Sciences and Research, Vallah, Amritsar, Punjab, India
  • Sangeeta Pahwa Department of Obstetrics and Gynecology, Sri Guru Ram Das Institute of Medical Sciences and Research, Vallah, Amritsar, Punjab, India



Lipid profile, Preeclampsia, Uterine artery Doppler


Background: Preeclampsia is associated with adverse pregnancy outcome and is a major cause of the fetomaternal morbidity and mortality. This study aimed at finding the role of lipid profile and uterine artery Doppler as a reliable predictor of risk of preeclampsia in early second trimester.

Methods: This study is conducted in the obstetrics and gynecology department of a tertiary care teaching hospital, Amritsar. Lipid profile and Uterine artery doppler is estimated in 100 antenatal women from 14-20 weeks of period of gestation who met the inclusion criteria and are followed up till delivery or till preeclampsia sets in.

Results: Out of 100 subjects 74 remained normotensive (Group A) and 26 developed preeclampsia (Group B). The mean serum level of total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL) and very low-density lipoprotein cholesterol (VLDL) was significantly higher in Group B as compared to group A women. The Preeclamptic women showed significant fall in high density lipoprotein cholesterol (HDL) level as compared to normal pregnant women. The mean S/D ratio, PI and RI values of uterine artery Doppler were higher for group B and were statistically significant.

Conclusions: The combined predictive value of lipid profile and uterine artery Doppler for estimating risk of preeclampsia was more reliable than of any of the test individually.


Cunningham F, Leveno KJ, Bloom SL, Hauth JC, Rouse DJ, Spong CY. Pregnancy hypertension: Text book of Williams Obstetrics; 2005;23(36):706-49.

Ghulmiyyah L, Sibai B. Maternal mortality from preeclampsia/eclampsia. Seminars Perinatol. 2012;36(1):56-9.

Shanmugavadivu L, Sundari K, Devi P. Early predictors of PIH: serum beta-HCG and lipid profile. Inter J Reprod Contracept Obstet Gynecol. 2016;4142-5.

Expert Panel on Detection E. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA. 2001;285(19):2486.

Kumari K, Singh U, Maharshi S, Singh R. Assessment of serum lipid profile in early pregnancy and its relation with pre-eclampsia: a prospective study. Int J Reprod Contracept Obstet Gynecol. 2016;5:840-4.

Padmapriya M. Padmapriya M. Lipid profile in second trimester of pregnancy as a predictor of preeclampsia in patients attending antenatal clinic in Kilpauk Medical College and Hospital: A prospective cohort study (Doctoral dissertation, Kilpauk Medical College, Chennai). 2013. Available at: Accessed on 15th May 2019.

Kooffreh M, Ekott M, Ekpoudom D. The prevalence of pre-eclampsia among pregnant women in the University of Calabar Teaching Hospital, Calabar. Saudi J Health Sci. 2014;3(3):133.

Mukherjee R, Ray CD, Chakraborty C, Dasgupta S, Chaudhury K. Clinical biomarker for predicting preeclampsia in women with abnormal lipid profile: statistical pattern classification approach. Inter Conf Syst Med Biol. 2010:397-401

Gohil J, Patel P, Gupta P. Estimation of lipid profile in subjects of preeclampsia. The J Obstet Gynecol India. 2011;61(4):399-403.

Vidyabati R, Hijam D, Singh N, Singh W. Serum ßhCG and lipid profile in early second trimester as predictors of pregnancy induced hypertension. The J Obstet Gynecol India. 2010;60(1):44-50.

Vani I, Gayathri A, Nagamani T, Sunieeta H. Lipid profile parameters in normal and preeclampsia complicating pregnancies-a prospective observational study. The Am J Sci Med Res. 2015;1:40-3.

Rupnawar PB, Ajith S, Rajalakshmi TN. To assess uterine artery Doppler findings at 18- 22 weeks in predicting adverse pregnancy outcome. IOSR 2015;14(8):95-100.

Sahoo K, Shaha P, Bhairagond S, Raj V. The Role of Uterine Artery Doppler Sonography in Predicting Pre Eclampsia at 14-20 Weeks of Gestation. Inter J Sci Res (IJSR). 2016;5(2):37-47.






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