Prophylactic antibiotics for hysterectomy and cesarean section: amoxicillin-clavulanic acid versus cefazolin

Authors

  • Jyoti Malik Department of Obstetrics and Gynaecology, SHKM Govt. Medical College, Nalhar, Haryana, India
  • Sibadatta Das Department of Physiology, SHKM Govt. Medical College, Nalhar, Haryana, India
  • Ashima Das Department of Anatomy, SHKM Govt. Medical College, Nalhar, Haryana, India
  • Pinki Rai Department of Anatomy, SHKM Govt. Medical College, Nalhar, Haryana, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20160839

Keywords:

Antibiotic prophylaxis, Hysterectomy, Abdominal, Vaginal, Cesarean delivery, Elective, Emergency

Abstract

Background: To compare amoxicillin-clavulanic acid with cefazolin as short term antibiotic prophylaxis in women undergoing hysterectomy and elective casarean section.

Methods: 60 women undergoing hysterectomy were randomly assigned either to 2.4 g intravenous amoxicillin-clavulanic acid (AMX/CL) or 2 g cefazolin 30 min before hysterectomy. 122 women delivered by elective cesarean were randomized to a single dose of either of above antibiotics at cord clamping. Each patient was assessed daily until

discharge for evidence of febrile status and the presence of infection at the operative site and urinary tract.

Results: Infectious morbidity was found in 11% and 12.5% of hysterectomy patients in AMX/CL and cefazolin cases respectively. 10 women had post-cesarean infections (6 AMX/CL, 4 cefazolin, p=0.51).

Conclusions: Broad spectrum amoxicillin-clavulanic acid was not superior to cefazolin in prevention of post-operative infection when given as prophylaxis in hysterectomy and elective cesarean section.

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Published

2016-12-27

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Original Research Articles