A prospective study of demographic profile, risk factors and pregnancy outcome in Hepatitis B and Hepatitis C virus positive pregnant women in a tertiary care centre

Arti Sharma, Shubhra Agarwal, Garima Bajpai, Anupriya Singh, Nikita Agarwal, Shweta Mishra


Background: Viral hepatitis is the most common liver disease in pregnancy and is also the most common cause of jaundice in pregnancy in tropical countries. Risk factors for transmission are intravenous drug abuse, surgical and dental procedures done without adequate sterilization of instruments, sexual route etc. Early diagnosis and management can prevent maternal and fetal complications. This study was done to evaluate the frequency, risk factors and pregnancy outcome in hepatitis B virus (HBV) and hepatitis C virus (HCV) positive antenatal women.

Methods: This case control study was conducted in Teerthankar Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, India from January 2017 to June 2018 on total 2511 pregnant women. The serum samples were checked for presence of hepatitis B surface antigen (HBsAg) and presence of IgG antibodies to HCV. Analysis of sociodemographic profile, risk factors and pregnancy outcome were done in all HBV and HCV positive women.

Results: Out of 2511 pregnant women, 292 were tested positive for hepatitis. Maximum number of women were in the age group of 21-30 years. Most of the seropositive women were multipara. Frequency of positivity was maximum for HCV (67.1%). The risk factors for transmission in study population were intravenous drug abuse, blood transfusion, history of surgery and tattooing.

Conclusions: Hepatitis infection rate is increasing. Universal screening for HBV and HCV can be recommended in pregnant women in developing countries. Education and awareness of public and health care workers can reduce the risk of transmission.



Antenatal women, Hepatitis B virus, Hepatitis C virus, Transmission

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Baldo V, Baldovin T, Trivello R. Epidemiology of HCV infection. Curr Pharm Des. 2008;14:1646-54.

Kumar A, Sharma KA, Gupta RK. Prevalence and risk factors for hepatitis C virus among pregnant women. Indian J Med Res. 2007;126:211-5.

Conte D, Fraquelli M, Prati D, Colucci A, Minola E. Prevalence and clinical course of chronic hepatitis C virus (HCV) infection and rate of HCV vertical transmission in a cohort of 15,250 pregnant women. Hepatol. 2000;31:751-5.

ACOG Educational Bulletin. Viral hepatitis in pregnancy. Int J Gynaecol Obstet. 1998;63:195-202.

Ericksen NL. Perinatal consequences of Hepatitis C. Clin Obstet Gynecol. 1999;42:121-33.

Summaries for patients. Hepatitis C virus infection in United States 1999 through 2002. Am Intern Med. 2006;144:120.

Zhou DX, Tang JW, Chu IM, Cheung JL, Tang NL, Tam JS, et al. Hepatitis C virus genotype distribution among intravenous drugs user and the general population in Hong Kong. J Med Virol. 2006;78(5):574-81.

Shah NH, Shabbir G. A review of published literature on Hepatitis B and C virus prevalence in Pakistan. JCPS Pakistan. 2002;12:368-71.

Garner JJ, Gaughwin M, Dodding J, Wilson K. Prevalence of Hepatitis C infection in pregnant women in South Australia. Med J Aust. 1997;167(9):470-2.

Marranconi F. Fabris P, Stecca C, Zampieri L, Battini MC, DiFabrizio N, et al. Prevalence of anti-HCV and risk factor for hepatitis c virus infection in healthy pregnant women. Infect. 1994;22:333-7.

Ward C, Tudor-Williams G, Cotzias T, Hargreaves S, Regan L, Foster GR. Prevalence of hepatitis C among pregnant women attending an inner London obstetric department: uptake and acceptability of named antenatal testing. Gut. 2000;47(2):277-80.

Silverman NS, Jenkin BK, Wu C, McGillen P, Knee G. Hepatitis C virus in pregnancy: seroprevalence and risk factors for infection. Am J Obstet Gynecol. 1993;169:583-7.

Chakarvati A, Kar P, Gupta RK, Sharma KA, Kumar A. Prevalence and risk factor for Hepatitis C virus among pregnant women. Indian J Med Res. 2007;126:211-25.

Raptopoulou, Gigi M, Orphanou E, Lalla TH, Lita A, Garifallos A. Prevalence of Hepatitis C virus infection on cohort of pregnant women in Northern Greece and transmission of HCV from mother to child. Eur J Epidemiol. 2001;17:236-6.

Jadoon HA, Ahmed Z. Prevalence of anti-HCV in blood donors of hazara (NWFP) Pakistan. J Med Res. 1999;38:7-9.

Jabeen T, Cannon B, Hogan J, Crowley M, Devereux C, Fanning L, et al. Pregnancy and pregnancy outcome in hepatitis C type 1b. QJM. 2000;93:597-601.

Awan NS, Asraf N, Nayyar S. Obstetrics and perinatal outcome; risk factors for hepatitis B and C transmission. Professional Med J. 2006;13(4):511-6.

Marti C, Pena JM, Bates I, Madero R, De Jose I, Pallardo LF, et al. Obstetric and perinatal complications in HIV-infected women. Analysis of cohort of 167 pregnancies between 1997 and 2003. Acta Obstet Gynecol Scand. 2007;86(4):409-15.

Upreti P, Singh RK, Arya V. Burden of HCV infection among pregnant women with assessment of risk factors and pregnancy outcome in HCV infected: A hospital-based study from Uttarakhand. JMSCR. 2017;5(1):17249-56.

Lobstein S, Faber R, Tillmann HL. Prevalence of hepatitis B among pregnant women and its impact on pregnancy and newborn complications at a tertiary hospital in the eastern part of Germany. Digest. 2011;83(1-2):76-82.