Comparison of obstetric outcomes with use of two different standard doses of oxytocin for induction of labor


  • Alka Gupta Department of Obstetrics and Gynecology, Seth G. S. Medical College and KEM Hospital, Mumbai, Maharashtra, India
  • Rucha Thakare Department of Obstetrics and Gynecology, Seth G. S. Medical College and KEM Hospital, Mumbai, Maharashtra, India
  • Madhva Prasad Department of Obstetrics and Gynecology, Seth G. S. Medical College and KEM Hospital, Mumbai, Maharashtra, India



Amniotomy, Oxytocin, Induction


Background: The interventions used in a suspected abnormal labor include amniotomy (artificial rupture of membranes), oxytocin infusion, forceps application and caesarean section. No study is available for individualised treatment with oxytocin. Considering the literature review, many unanswered questions remain regarding the use of oxytocin and definite improvements are possible. All this led us to choose this as the topic for study.

Methods: This study was conducted over a duration of 18 months (January 2017 to June 2018) where ninety (90) laboring patients admitted in a tertiary care hospital were included. They were categorized into two groups, one group (30 patients) received the low dose and the other group (60 patients) received high dose oxytocin infusions. The labor outcomes including the maternal and fetal outcomes were observed.

Results: The average age in the study population was 26 years and the average gestation was 38 weeks. The overall rate of cesarean section in this study was 16.67% (23.33% in the low dose group and 13.33% in the high dose group). Gravidity and parity have an association with the vaginal delivery.

Conclusions: It is safe to use oxytocin infusion either in the low dose or the high dose for induction of labor as both the regimens are equally effective and comparable in terms of outcomes. The low dose oxytocin regimen can be safely recommended in a patient requiring oxytocin infusion for induction of labor and the treating doctor should consider starting with low dose oxytocin.



Theobald GW, Graham A, Campbell J, Gange PD, Driscoll WJ. The use of post-pituitary extract in physiological amounts in obstetrics; a preliminary report. Br Med J. 1948;2(4567):123-7.

Shu-Qin W, Zhong-Cheng L, Hui-Ping Q. High-dose versus low-dose oxytocin for labor augmentation: a systematic review. Am J Obstet Gynecol, 2010;203:296-304.

Wiberg-Itzel E, Akerud H, Andolf E, Hellström-Westas L, Winbladh B, Wennerholm UB. Association between adverse neonatal outcome and lactate concentration in amniotic fluid. Obstet Gynecol, 2011;118:135-42.

Tribe RM, Crawshaw SE, Seed P, Shennan AH, Baker PN. Pulsatile versus continuous administration of oxytocin for induction and augmentation of labor: two randomized controlled trials. Am J Obstet Gynecol. 2012;206:230.e1-8.

Kenyon S, Armstrong N, Johnston T, Walkinshaw S, Petrou S, Howman A, et al. Standard or high-dose oxytocin for nulliparous women with confirmed delay in labour: quantitative and qualitative results from a pilot randomised controlled trial. BJOG. 2013;120(11):1403-12.

Selin L, Wennerholm UB, Jonsson M, Dencker A, Wallin G, Wiberg-Itzel E, et al. High-dose versus low-dose of oxytocin for labour augmentation: a randomised controlled trial. Women Birth. 2018:S1871-5192(18)30363-9.

Budden A, Chen LJ, Henry A. High-dose versus low-dose oxytocin infusion regimens for induction of labour at term. Cochrane Database Syst Rev. 2014;10:CD009701.

Wormer KC, Williford AE. Bishop Score. In: Stat Pearls. Treasure Island (FL): stat pearls publishing; 2018. Available at: Accessed on 10th March 2020.

Middleton P, Shepherd E, Crowther CA. Induction of labour for improving birth outcomes for women at or beyond term. Cochrane Database Syst Rev. 2018;5:CD004945.

Bostancı E, Kilicci C, Ozkaya E, Abide YC, Eroglu M. Continuous oxytocin versus intermittent oxytocin for induction of labor: a randomized study. J Matern Neonatal Med. 2018;1-6.






Original Research Articles