An encounter with alobar holoprosencephaly: a case report


  • Prasanna Venugopalan Department of Obstetrics and Gynecology, Travancore Medical College Hospital, Kollam, Kerala, India
  • Fathima Mithilag Department of Obstetrics and Gynecology, Travancore Medical College Hospital, Kollam, Kerala, India
  • Vidhu V. Nair Department of Obstetrics and Gynecology, Travancore Medical College Hospital, Kollam, Kerala, India



Alobar, Cyclopia, Holoprosencephaly, Proboscis, Recurrence, Sporadic, Termination


Alobar holopresencephaly is a rare embryonic condition where there is anomalous fusion of cerebral hemispheres. The key features include neurological impairment and facial dysmorphism like cyclopia, ocular hypertelorism with divided orbits and a proboscis. Obstetric ultrasound and foetal MRI are the diagnostic modalities. Majority of cases are sporadic in origin while a genetic association is also described. A small recurrence risk is noted in cases with sporadic origin. Early diagnosis and pregnancy termination are advisable for the condition since the survival rate is very low.


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Case Reports