A comparative study of serum magnesium levels in preterm labour and term labour

Malathi T., Sowmya Sampurna Maddipati


Background: The objective of present study was to measure the serum magnesium levels in preterm labor patients, to measure the serum magnesium levels in term labor patients and to correlate the serum magnesium levels in preterm and term labor patients.

Methods: It is a prospective case control study conducted in the department of obstetrics and gynecology, KIMS hospital and research Centre, Bengaluru, Karnataka, India. A venous blood sample is drawn from patients admitted to labor room who fulfill the inclusion and exclusion criteria out of which 50 patients belong to the Group-A (preterm labor) and 50 patients belong to Group-B (term labor). Serum magnesium level is measured in both the groups.

Results: Women with preterm labor had a significantly reduced serum magnesium level with a mean serum magnesium level of 1.59 mg/dl with a SD of 0.83 whereas the patients with term labor had a mean serum magnesium level of 2.55 mg/dl with a SD of 0.40. The difference of serum magnesium levels observed between the study population and control population is independent of factors like maternal age, parity, gestational age, and socio-economic factors. In this study, it is found that serum magnesium levels are lower in early and late preterm compared to preterm between 33-34+6 weeks.

Conclusions: Serum magnesium level can be used as a predicting tool for preterm labor. Preterm labor can be avoided by simple supplementation of Magnesium which might provide an easy and inexpensive means to decrease the problems related to preterm labor. There is a further scope for research on serum magnesium levels based on gestational age.


Preterm labor, Serum magnesium level, Term labor

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Cunningham, Lenovo, Bloom, Hoffmann, Spong, Dashe, Casey, Sheffield Williams Obstetrics, 24th ed; 2014: 829-833.

Kamal S, Sharan A, Kumar U, Shahi SK. Serum magnesium level in preterm labour. Indian J Pathol Microbiol. 2003;46(2):271-3.

Arias, Deftary, Bhide. Preterm parturition syndrome. Practical guide to high risk pregnancy and delivery: a South Asian Perspective, 3rd Edition; 2008:193-204.

Lumley, J. Defining the problem: the epidemiology of preterm birth. Br J Obstet Gynaecol. 2003;110:3-7.

Peacock JL, Bland JM, Anderson HR. Preterm delivery; effect socioeconomic factors, psychological stress, smoking, alcohol, and cffeine. BMJ. 1995;311:531.

Kurzal RB. Serum magnesium level in pregnancy and preterm labour. Am J Perinatol. 1991;8:119-27.

Whitney EN, Cataldo CB, Rolfes SR. 6th ed. Understanding normal and clinical nutrition, Belmont, CA: Wadsworth; 1996.

Jeroen HF, de Baaij, Hoenderop GJ, Bindels RJM. Magnesium in man: implication for health and disease. Physiol Reviews. 2015;95(1):1-46.

Griffin IJ. Encyclopedia of food sciences and nutrition (Second Edition); 2003: 3641.

Smith R. Parturition. N Engl J Med. 2007;365:27183.

Rosner B, Fundamentals of Biostatistics, 5th ed, Duxbury; 2000 :80-240

Riffenburg RH. Statistics in Medicine, 2nd ed, Academic press; 2005 :85-125.

Sunder Rao PSS, Richard J. An Introduction to Biostatistics, A manual for students in health sciences, New Delhi: Prentice hall of India. 4th ed; 2006: 86-160.

Suresh KP, Chandrasekhar S. Sample Size estimation and Power analysis for clinical research studies. J Human Reprod Sci. 2012;5(1):7-13.

Pushpo D, Jagdish WMA. A study of serum magnesium level in preterm labour. J Obstet Gynaecol India. 1991;41:269-73.

Smolarczyk R, Wójcicka-Jagodzińska J, Romejko E, Piekarski P, Czajkowski K, Teliga J. Calcium-phosphorus-magnesium homeostasis in women with threatened preterm delivery. Inter J Gynecol Obstet. 1997;57(1):43-8.

Wójcicka‐Jagodzińska J, Romejko E, Piekarski P, Czajkowski K, Smolarczyk R, Lipiński T. Second trimester calcium‐phosphorus‐magnesium homeostasis in women with threatened preterm delivery. Int J Gynecol Obstet. 1998;61(2):121-5.

Begum H, Shamsuddin L, Khatun S. Relationship of preterm labour with serum magnesium level. Bangladesh J Obstet Gynaecol. 2004;19(1):3-6.