Primary malignant melanoma of vagina: a case report

Smruti Gedam, Tarachand Sharma


Primary malignant melanoma of the vagina is a rare and aggressive disease with worse prognosis as compared with non-genital melanomas or other vaginal malignant neoplasms. Presented here is a case of 42 years female with 3 months history of amenorrhea and vaginal discharge. On vaginal examination, a firm growth of size approximately 7-8 cm was found attached to the left postero-lateral wall of vagina and extending up to the introitus. On biopsy and histopathological examination, it was diagnosed as a case of high-grade malignant melanoma of amelanotic type. Radiotherapy was started as a part of treatment after consultation with an oncologist, considering non-resectable nature of the mass. The patient received first 5 cycles of radiotherapy but succumbed to the disease during treatment.


Amelanotic melanoma, Primary malignant melanoma, Vaginal melanoma

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Hu DN, Yu GP, McCormick SA. Population-based incidence of vulvar and vaginal melanoma in various races and ethnic groups with comparisons to other site-specific melanomas. Melanoma Res. 2010;20(2):153-8.

Fulciniti F, Ascierto PA, Simeone E, Bove P, Losito S, Russo S, et al. Nevoid melanoma of the vagina: report of one case diagnosed on thin layer cytological preparations. Cyto J. 2007;4:14.

Piura B, Rabinovich A, Yanai-Inbar I. Primary malignant melanoma of the vagina: case report and review of literature. Eur J Gynaecol Oncol. 2002;23(3):195-8.

Samolis S, Panagopoulos P, Kanellopoulos N, Papastefanou I, Karadaglis S, Katsoulis M. Primary melanoma of the vagina: a case report. Eur J Gynaecol Oncol. 2010;31(2):233-4.

Frumovitz M, Etchepareborda M, Sun CC, Soliman PT, Eifel PJ, Levenback CF, et al. Primary malignant melanoma of the vagina. Obstet Gynecol. 2010;116(6):1358-65.

Tjalma WA, Monaghan JM, Naik R, Nordin A. Primary vaginal melanoma and long-term survivors. Eur J Gynaecol Oncol. 2001;22(1):20-2.

Lin LT, Liu CB, Chen SN, Chiang AJ, Liou WS, Yu KJ. Primary malignant melanoma of the vagina with repeated local recurrences and brain metastasis. J Chinese Med Associat. 2011;74(8):376-9.

Mino RA, Mino VH, Livingstone RG. Primary melanoma of the vagina, with a review of the literature. Am J Obstet Gynecol. 1948;56(2):325-34.

Baloglu A, Bezircioglu I, Cetinkaya B, Yavuzcan A. Primary malignant melanoma of the vagina. Arch Gynecol Obstet. 2009;280(5):819-22.

Gupta D, Malpica A, Deavers MT, Silva EG. Vaginal melanoma: a clinicopathologic and immunohistochemical study of 26 cases. The Am J Surg Pathol. 2002;26(11):1450-7.

Reid GC, Schmidt RW, Roberts JA, Hopkins MP, Barrett RJ, Morley GW. Primary melanoma of the vagina: a clinicopathologic analysis. Obstet Gynecol. 1989;74(2):190-9.

Chaudhuri S, Das D, Chowdhury S, Gupta AD. Primary malignant melanoma of the vagina: A case report and review of literature. South Asian J Cancer. 2013;2(1):4.

McKinnon JG, Kokal WA, Neifeld JP, Kay S. Natural history and treatment of mucosal melanoma. J Surg Oncol. 1989;41(4):222-5.

Moros ML, Ferrer FP, Mitchell MJ, Romeo JA, Lacruz RL. Primary malignant melanoma of the vagina: poor response to radical surgery and adjuvant therapy. Eur J Obstet Gynecol Reprod Biol. 2004;113(2):248-50.

Benedet JL, Pecorelli S, Ngan HY, Hacker NF, Denny L, Jones III HW, et al. Staging classifications and clinical practice guidelines for gynaecological cancers. Int J Gynecol Obstet. 2000;70:207-312.

Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Annals Surg Oncol. 2010;17(6):1471-4.

Seifried S, Haydu LE, Quinn MJ, Scolyer RA, Stretch JR, Thompson JF. Melanoma of the vulva and vagina: principles of staging and their relevance to management based on a clinicopathologic analysis of 85 cases. Annals Surg Oncol. 2015;22(6):1959-66.

Kirschner AN, Kidd EA, DeWees T, Perkins SM. Treatment approach and outcomes of vaginal melanoma. Int J Gynecol Cancer. 2013;23(8):1484-9.

Leitao MM, Cheng X, Hamilton AL, Siddiqui NA, Jurgenliemk-Schulz I, Mahner S, et al. Gynecologic Cancer InterGroup (GCIG) consensus review for vulvovaginal melanomas. Int J Gynecol Cancer. 2014;24(Supp 3):S117-22.

Piura B. Management of primary melanoma of the female urogenital tract. The Lancet Oncol. 2008;9(10):973-81.