Maternal outcome in thyroid dysfunction in admitted antenatal women in tertiary care centre: an observational study


  • Juhi Agarwal Department of Obstetrics and Gynecology, Gandhi Medical College, Bhopal, Madhya Pradesh, India
  • Deepika Kesaraju Department of Obstetrics and Gynecology, Gandhi Medical College, Bhopal, Madhya Pradesh, India
  • Poorva Badkur Department of Obstetrics and Gynecology, Gandhi Medical College, Bhopal, Madhya Pradesh, India



Antenatal, Hypothyroidism, Maternal, Outcomes, Thyroid dysfunction


Background: Thyroid disorders constitute one of the most common endocrine disorders in pregnancy. Aim of this study was to identify thyroid dysfunction as a maternal health problem. Objective of this study was to study the maternal outcomes in these patients.

Methods: The main source of data are the patients admitted in Sultania Zanana Hospital, GMC Bhopal. The study was an observational prospective study conducted from March 2018 to February 2019.

Results: The present study was conducted in department of obstetrics and gynecology, Gandhi Medical College and associated Sultania Zanana Hospital Bhopal for the period of 1 year. The study could enroll 400 females fulfilling the inclusion criteria during the study period.

Conclusions: In developing countries like India where there is prominent micronutrient deficiency, iodine deficiency further aggravates the condition and carries a great potential to show deleterious impacts on maternal and fetal outcomes, thus serving a major health problem. Considering the substantial increase in short term as well as long term perinatal morbidity, a felt need for creating awareness not only on adverse outcomes but also detection of the disorder in first trimester is required. The desired perinatal outcome can be achieved by early detection and prompt treatment of the disorder. Henceforth, universal screening of all antenatal women in the first trimester rather than targeted case finding should be recommended at all the health care facilities.


Gupta K. Thyroid disorders and pregnancy. FOGSI FOCUS-Med Dis Preg. 2009;10:59-66.

Sreelatha S, Nadagoudar S, Devi L, Asha. The study of maternal and fetal outcome in pregnant women with thyroid disorders. Int J Reprod Contracept Obstet Gynecol. 2017;6:3507.

Dhanwal DK, Bajaj S, Rajput R, Subramaniam KA, Chowdhury S, Bhandari R, et al. Prevalence of hypothyroidism in pregnancy: An epidemiological study from 11 cities in 9 states of India. Indian J Endocrinol Metabol. 2016;20(3):387.

Vaidya B, Anthony S, Bilous M, Shields B, Drury J, Hutchiso S, et al. Detection of thyroid dysfunction in early pregnancy Universal screening or targeted high risk case finding? J Clin Endocrinol Metab. 2007;92-203-7.

Negro R, Schwartz A, Gismondi R, Tinelli A, Mangieri T, Stagnaro-Green A. Universal screening vs case finding for detection and treatment of thyroid hormonal dysfunction during pregnancy. J Clin Endocrinol Metab. 2010;95:1699-707.

Meena DS, Bhati I, Bora S, Meena S. Study of thyroid dysfunction in pregnancy. Int J Curr Microbiol App Sci. 2015;4(9):91-7.

Nazarpour S, Ramezani Tehrani F, Simbar M, Azizi F. Thyroid dysfunction and pregnancy outcomes. Iran J Reprod Med. 2015;13(7):387-96.

FOGSI good clinical practice recommendations on pre conceptional care- India; 2016;4(2.1):6-7.

Indian thyroid society, FOGSI. Recommendations for the management of thyroid dysfunction in pregnancy. 2019:11-12.

Lazarus J, Brown RS, Daumerie C, Hubalewska-Dydejczyk A, Negro R, Vaidya B. 2014 European thyroid association guidelines for the management of subclinical hypothyroidism in pregnancy and in children. Eur Thyroid J. 2014;3(2):76-94.

Sastre-Marcos J, Val-Zaballos F, Ruiz-Ginés MÁ, Saura-Montalbán J, Veganzones-Pérez M. Reference values and universal screening of thyroid function in the first trimester of the population of pregnant women in Toledo (Spain). Endocrinologia nutricion (English Edition). 2015;7(62):358-60.

NHM. National Guidelines for Screening of hypothyroidism during pregnancy, Ministry of Health and Family Welfare, Government of India; 2014.

Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, et al. Guidelines of the American thyroid association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011;21(10):1081-125.

Lazarus JH, Bestwick JP, Channon S, Paradice R, Maina A, Rees R, et al. Antenatal thyroid screening and childhood cognitive function. N Eng J Med. 2012;366(6):493-501.

Tanuja PM, Rajgopal K, Sadiqunnisa. Thyroid dysfunction in pregnancy and maternal outcome. IOSR-JDMS. 2014;13(1):11-5.

Kalra B, Choudhary M, Thakral M, Kalra S. Prevalence of hypothyroidism in term pregnancies in North India. Indian J Endocr Mtab. 2018;22:13-5.

Ozdemir H, Akman I, Coskun S, Demirel U, Turan S, Bereket A, et al. Maternal thyroid dysfunction and Neonatal thyroid problems. Int J Endocrinol. 2013;2013:987843.

Rajalakshmi MS, Singh AK, Sujit D, Samchetsabam RD. The fetomaternal outcome in maternal hypothyroidism complicating pregnancies at RIMS: a prospective study. Eur J Pharm Med Res. 2016;3:452-9.

Gupta RD. Thyroid disorders in pregnancy. Curr Med Issues. 2018;16:48-51.

Saki F, Dabbaghmanesh MH, Ghaemi SZ, Forouhari S, Omrani GR, Bakhshayeshkaram M. Thyroid function in pregnancy and its influences on maternal and fetal outcomes. Int J Endocrinol Metab. 2014;12(4):e19378.






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