Pregnancy with pancytopenia: an observational study
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20203045Keywords:
Micronutrients, Pancytopenia, PregnancyAbstract
Background: Pancytopenia is the reduction in all three major cellular elements of blood; hence it is the simultaneous presence of anaemia, leukopenia and thrombocytopenia. Pancytopenia is associated with many maternal and foetal complications during pregnancy like maternal sepsis, postpartum haemorrhage, pre-eclampsia and preterm labour, IUGR and intrauterine foetal demise.
Methods: The study was conducted at BLDE (Deemed to be) University, Shri B. M. Patil Medical College Hospital and Research Centre. It’s an observational study done from November 2019-April 2020. The participants enrolled in the study were subjected for further clinical and laboratory evaluation and followed for feto-maternal outcome.
Results: The incidence of pancytopenia with pregnancy in this study was 3% and all the patients were vegetarian by diet along with vitamin B12 and folic acid deficiency. They were associated with different maternal and foetal complications.
Conclusions: Proper dietary counselling and well-balanced dietary plans even with plant originate food can prevent the micronutrients deficiency and avoid the deleterious consequences like pancytopenia.
References
Metikurke SH, Bhavika R. Correlation of bone marrow aspirate, biopsies and touch imprint findings in pancytopenia. J Hematol. 2013;2(1):8-13.
Varma N, Dash S. A reappraisal of underlying pathology in adult patients presenting with pancytopenia. Trop Geograph Med. 1992;44(4):322-7.
Visentin CE, Masih SP, Plumptre L, Schroder TH, Sohn KJ, Ly A, et al. Low serum vitamin B-12 concentrations are prevalent in a cohort of pregnant Canadian women. The J Nutrit. 2016;146(5):1035-42.
Breymann C. Iron deficiency and anaemia in pregnancy: modern aspects of diagnosis and therapy. Eur J Obstet Gynecol Reprod Biol. 2005;123:S3-13.
World Health Organization. Worldwide prevalence of anaemia 1993-2005: WHO global database on anaemia, 2008. Available at: https://www.who.int/nutrition/publications/micronutrients/anaemia_iron_deficiency/9789241596657/en/. Accessed on 12th April 2020.
Shimamura A, Alter BP. Inherited aplastic anaemia syndromes. In Wintrobe's Clinical Hematology: Thirteenth Edition; Wolters Kluwer Health Adis (ESP); 2013:954-964.
Imbert M, Scoazec JY, Mary JY, Jouzult H, Rochant H, Sultan C. Adult patients presenting with pancytopenia: a reappraisal of underlying pathology and diagnostic procedures in 213 cases. Hematol Pathol. 1989;3(4):159-67.
Pawlak R, Parrott SJ, Raj S, Cullum-Dugan D, Lucus D. How prevalent is vitamin B12 deficiency among vegetarians?. Nutrit Rev. 2013;71(2):110-7.
Rajput Y, Wankhede UN. A rare case report: pregnancy with pancytopenia. Int J Reprod Contracept Obstet Gynecol. 2017;6(12):5633-5.