Chromohysteroscopy after failed intracytoplasmic sperm injection

Authors

  • Emad E. Khalifa Department of Obstetrics and Gynecology, Alexandria University, Alexandria, Egypt
  • Mohamed A. El Samra Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Alexandria
  • Tamer H. Said Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Alexandria
  • Noha Abdin Ministry of Health, El Behera, Egypt

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20160859

Keywords:

Chromohysteroscopy, Intracytoplasmic, Sperm injection

Abstract

Background: ICSI is the injection of a single sperm directly into the cytoplasm of the oocyte (ICSI). The failure to achieve pregnancy after ICSI has been studied over many years to reach the possible and preventable causes to avoid another failure. The aim of this study was to assess the value of using Chromohysteroscopy as a part of the work up of cases with one or more failed ICSI. The Ultimate goal is to detect the possible endometrial abnormalities and /or endometritis.

Methods: Prospective cohort study was carried out with total of 50 infertile women recruited from infertility clinic in Elshatby Maternity University Hospital, Alexandria University, Egypt. Cases were allocated in 2 groups with 25 cases in each group. The first group included cases that had a failed trial of ICSI. The second group included control cases who were seeking for fertility treatment with no previous history of ICSI or any uterine surgery or anatomical abnormalities. In the postmenstrual period, Chromohysteroscopy was done by the same surgeon and documentation of all findings in the cavity and presence of endometritis.

Results: There was a significant increase in the incidence of endometritis among the study group 68% in comparison to 16% in the control group.

Conclusions: In this study endometrial dying with methylene blue at hysteroscopy improve the detection of chronic endometritis.

References

Oehninger S, Gosden RG. Should ICSI be the treatment of choice for all cases of in-vitro conception? No, not in light of the scientific data. Hum. Reprod. 2002;17:2237-42.

French DB, Sabanegh ES, Goldfarb J, Desai N. Does severe teratozoospermia affect blastocyst formation, live birth rate, and other clinical outcome parameters in ICSI cycles? Fertil Steril. 2010;93(4):1097-103.

Petrozza JC. Assisted Reproduction Technology Hum Reprod Update. 2006:1039-1049.

Oliveira FG, Abdelmassih VG, Diamond MP, Dozortsev D, Nagy ZP, Abdelmassih R. Uterine cavity findings and hysteroscopic interventions in patients undergoing in vitro fertilization–embryo transfer who repeatedly cannot conceive. Fertil Steril. 2003;80:1371-5.

Kermer C, Duffy S, Moroney M. Patient's satisfaction with outpatient hysteroscopy versus day care hysteroscopy: Randomized controlled trial. Br Med J. 2000;320:279-82.

Workowski KA, Berman S. Sexually transmitted diseases treatment guidelines, 2010. MMWR Recommend Rep. 2010;59:1-110.

Marconi G, Vilela M, Quintana R, Diradourian M, Young E, Sueldo C. New observations on endometrial physiology after Transcervical injection of methylene blue dye. Fertil Steril. 2004;82:1700-4.

Gardner DK, Schoolcraft WB, Wagley L, Schlenker T, Stevens J and Hesla J. A prospective randomized trial of blastocyst culture and transfer in in-vitro fertilization. Hum. Reprod. 1998;13:3434-40.

French LM, Smaill FM. Antibiotic regimens for endometritis after delivery. Cochrane Database Syst Rev. 2004;CD001067.

Marconi G, Vilela M, Bello J. Sueldo Endometrial lesions caused by catheter used for embryo transfers: a preliminary report Fertil Steril. 2003;80:363-7.

Kucuk T, Safali M. Chromohysteroscopy for evaluation of endometrium in recurrent in vitro fertilization failure J Assist Reprod Genet. 2008;25:79-82.

Oliveira FG, Abdelmassih VG, Diamond MP, Dozortsev D, Nagy ZP, Abdelmassih R. Uterine cavity findings and hysteroscopic interventions in patients undergoing in vitro fertilization–embryo transfer who repeatedly cannot conceive. Fertil Steril. 2003;80:1371-5.

Barati M, Zargar M, Masihi S, Borzoo L, Cheraghian B. Office hysteroscopy in infertility. International journal of fertility and sterility. 2009;3(1):17-20.

Zeyneloglu HB, Onalan G, Dursun P, Altuntas B. Polypoid appearance of the endometrium on office hysteroscopy a significant predictor of miscarriage after IVF–ET. Fertil Steril. 2007;88:S96.

Cicinelli E, Resta L, Nicoletti R, Zappimbulso V, Tartagni M, Saliani N. Endometrial micropolyps at fluid hysteroscopy suggest the existence of chronic endometritis. Hum Reprod. 2005;20:1386-9.

Bajekal N, Li TC. Fibroids, infertility and pregnancy wastage. Hum Reprod Update. 2000;6:614-20.

Barash A, Dekel N, Fieldust S, Segal I, Schechtman E, Granot I. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization. Fertil Steril. 2003;79:1317-22.

National Institute for Clinical Excellence Guidelines tools to optimize the IVF–ET procedure and its cost effectiveness. London: RCOG Press; 2004.

Wkim R, Raneiri DM. Assessment of the uterine cavity by saline hysteron-contrast-sonography before IVF: presented at the XVIIIth annual meeting of the ESHRE, Vienna, Austria Hum Reprod Program Suppl. 2002;17:165-6.

Shokeir TA, Shalan HM. Significance of endometrial polyps detected hysteroscopically in amenorrheic infertile women J Obstet Gynecol Res. 2004;30:84-9.

Fatemi HM, Kasius JC, Timmermans A. Prevalence of unsuspected uterine cavity abnormalities diagnosed by office hysteroscopy prior to in vitro fertilization Hum Reprod. 2010;25:1959-65.

Karayalcin R, Ozcan S, Moraloglu O. Results of 2500 office-based diagnostic hysteroscopies before IVF Reprod Biomed Online. 2010;20:689-93.

Gaviño-Gaviño F, Guzmán-González E, Reyes-Muñoz E, J. Villalpando-Bravo. Impact of office hysteroscopy in patients with a history of two or more cycles of IVF–ET failed pre-ICSI in assisted reproduction center Gynecol Obstet Mex. 2010;78:9-14.

Lorusso F, Ceci O, Bettocchi S. Office hysteroscopy in an in vitro fertilization program Gynecol Endocrinol. 2008;24:465-9.

Downloads

Published

2016-12-27

Issue

Section

Original Research Articles