Serum uric acid: a biochemical prognostic indicator of pregnancy outcomes among pre-eclampsia patients at the federal medical centre, Yenagoa
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20204778Keywords:
Pre-eclampsia, Eclampsia, Uric acid, Pregnancy outcomesAbstract
Background: High levels of uric acid concentration over normal pregnant values have been reported previously in established preeclampsia, hence it was suggested to be a useful biochemical prognostic marker of the disease.
Methods: This is a hospital based prospective case control study where 100 patients with preeclampsia were recruited consecutively as they were admitted. 100 non-pre-eclamptics were also recruited as control. The foetomaternal data, adverse perinatal outcomes, maternal serum uric acid levels as well as complications of preeclampsia were recorded into the protocol. Statistical analysis was done using SPSS 22.0. Level of significance was set at p<0.05.
Results: The mean age in the study group was 28±6.7 years while in the control group it was 31±6.5 years. The difference in age was not statistically significant (p=0.53). The mean serum uric acid level was significantly higher amongst participants with preeclampsia than in those without preeclampsia (405.6±995 µmol/L versus 232.7±26.3 µmol/L, p=0.00). Uric acid was statistically associated with the occurrence of eclampsia (p=0.03), Severe hypertension (0.03) and birth asphyxia (p=0.01).
Conclusions: The mean serum uric acid was higher in preeclampsia than non-preeclampsia patients. High levels of uric acid were found in eclampsia, severe hypertension and birth asphyxia. However, the prognostic accuracy for uric acid was low for most pregnancy outcomes.
Metrics
References
Ekine AA, Jeremiah I, Harry TC, West OL. Factors influencing the prevalence of preeclampsia –eclampsia in booked and unbooked patients in NDUTH. World J Med Sci. 2015;3(1):1-14.
Adeosun OG, Charles–Davies MA, Ogundahunsi OA, Ogunlewe J. Maternal and neonatal outcomes of preeclampsia in African black women, South West Nigeria. Greener J Med Sci. 2015;5(4):67-76.
Kwawukume EY, Emuveyan EE. Comprehensive Obstetrics in the Tropics. Ashante and Hittscher, Damsona. 2002:321-9.
Agboola A. Pregnancy induced hypertension, preeclampsia and chronic hypertension. In: Agboola A (ed). Textbook of Obstetrics and Gynaecology for Medical Students, 2nd ed. Heinemann Educational Books plc, Ibadan, Nigeria. 2006;348-59.
Sazina M, Khalid UK, Nayyar P. Correlation of serum uric acid with maternal age, parity, and severity of blood pressure in preeclamptic pregnancies. Cont J Med Res. 2008;2:28-34.
Rajalaxmi K, Nayak S, Manjulu S. Serum Uric Acid Level in Preeclampsia and its Correlation to Maternal and Fetal Outcome. Int J Bio Res. 2014;5(1):22-4.
Richard JJ, Miguel AL, Eric AG. Uric Acid: A Danger Signal From the RNA World That May Have a Role in the Epidemic of Obesity, Metabolic Syndrome, and Cardiorenal Disease: Evolutionary Considerations. Elsevier Inc J Sem Nephro. 2011;31(5):394-9.
Razia S, Selina A, Nasima S. Association of Serum Uric Acid with Preeclampsia: A Case Control Study. Delta Med Col J. 2013;1(2):46-50.
Slemons JM, Bogert LJ. The uric acid content of maternal and fetal blood. J Biol Chem. 1917;32:63-9.
Azza AM. Level of serum uric acid in patients with preeclampsia compared to controls in Khartoum Teaching Hospital. University of Khartoum Graduate College Medical and Health Studies Board, 2010.
Felix E, Olivier I, Pascal F. Blood uric acid level as a marker of increased risk of Eclampsia in Severe Preeclamptic patients: A Cross-Sectional Study in Two Tertiary Hospitals of Yaounde, Cameroon. Health Sci Dis. 2016;17(2):7-11.
Joel RL, Beth P, Mark B, James MR. Uric acid as a predictor of adverse maternal and perinatal outcomes in women hospitalized with preeclampsia. J Obstet Gynaecol Can. 2014;36(10):870-7.
Kanagasibai S. Biochemical Markers in the prediction of preeclampsia. Are we there yet? Inter J Gynaecol Obstet. 2010;1(12):102-5.
Lwamga SK, Lemeshow J. Sample size determination in health studies; a practical manual. Geneva. WHO 1991;15-21.
James GP, Bee DE, Fuller JB. Proteinuria; accuracy and precision of laboratory diagnosis by Dipstick analysis. Clin Chem. 1978;24:1934-9.
Prince CP, James DR. Analytical Review in Clinical Biochemistry: The measurement of Urate. Ann Clin Biochem. 1988;25:484-98.
Kooffrey ME, Ekoh M, Ekpoudom DO. The prevalence of preeclampsia among pregnant women in University of Calabar Teaching Hospital, Calabar. Saudi J Health Sci. 2014;3(3):133-6.
Sotunsa J, Sharma S, Imaralu J, Lee T, Adepoju A. The hypertensive disorders of pregnancy in Ogun State, Nigeria: Preeclampsia in low and middle income countries. Pregnancy Hypertension: Int J Women’s Cardio Health. 2016;6(3):209
Yakassai IA, Morhason-Bello IO. Risk factors for preeclampsia among women at antenatal booking in Kano, Northern Nigeria, Nigeria. J Heal Car low Resour Settin. 2013;1(1):46-9.
Asgharnia M, Mirblouk F, Kazemi S, Pourmarzi D. Maternal serum uric acid level and maternal and neonatal complications isn preeclamptic women: A cross-sectional study. Int J Reprod Biomed. 2017;15(9):583-8.
Prathap T, Kondareddy T. Uric acid as an important biomarker in hypertensive disorders in pregnancy. Int J Reprod Contracept Obstet Gynaecol. 2016;5(12):4382-4.
AjZquez-RodrAquez JG, Rico-Trejo EI. Role of Uric Acid in Preeclampsia-Eclampsia. Gynecol Obstet Mex. 2011;79(5):292-7.
Paternoster DM, Stella A, Plebani M, Gambaro G, Grella PV. Predictive markers of pre-eclampsia in hypertensive disorders of pregnancy. Int J Gynecol Obstet. 1999;66(3):237-43.
Martin AC, Brown MA. Could Uric Acid have a pathogenic Role in Preeclampsia? Nat Rev Nephro. 2010;6(12):744-8.
Downloads
Published
How to Cite
Issue
Section
