Maternal and fetal outcome in jaundice complicating pregnancy: a prospective study

Swati Sharma, Rupa Aherwar, Shashikala Jawade


Background: The objective of the study was to study maternal and fetal outcome in pregnancy complicated with jaundice.

Methods: 30 antenatal patients with clinical /laboratory evidence of Jaundice were selected for study in period between august 2014 to august 2015.

Results: The peak age of incidence in our study was 21-25 years (66.6%) and majority were primigravida (66.6%). All cases were in third trimester of pregnancy, 93.3% were unbooked, 73.3% were term, 60% were of lower socioeconomic status and 73.3% were urban. All patients presented with jaundice at time of admission. Pruritus was most common presenting symptom present in 60% of patients. Other presenting complaints were nausea, high BP, abdominal pain and petechiae. Viral Hepatitis was most important cause of jaundice in this study found in 46.7% of cases. Preeclampsia and ICP were other causes of jaundice in this study. Hepatitis B was the most common cause of acute hepatitis (26.7%) and incidence of hepatitis E was 13.3% in our study. Maternal mortality was found in 1 case of hepatitis E complicated with hepatic encephalopathy and coagulopathy. 2% of these patients developed FHF. All patients were kept in ICU for intensive monitoring. PPH was most common maternal complication in 60% of patients. There was 1 maternal death in our study. Of 30 patients, 12 had spontaneous onset of labour. All delivered vaginally of which 8(26.7%) were preterm of which 2 died, 4(13.3%) were IUFD, 12 (40%) had fetal distress with meconium stained liquor, 5 (16.6%) had PROM, 2 (6.7%) had fetal growth restriction and 2 (6.7%) delivered uneventfully.

Conclusions: Jaundice in pregnancy results in a very high perinatal as well as maternal morbidity and mortality, and requires an early diagnosis and careful management.


Jaundice in pregnancy, Viral hepatitis

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Guntupalli SR, Steingrub J. hepatic disease and pregnancy- an overview of diagnosis and management. Crit Care Med. 2005;33:332-3.

Salman MI. Changes in liver functions tests during pregnancy. J of al-anbar university forpure science. 2009;3(1).

Acharya N, Acharya S, Shukla S, Athvale R, Shaveta. Study of Jaundice in Pregnancy. Glb J of Med research. 2013;13:25-9.

Oladokun A, Otegbayo JA, Adeniyi AA maternal and fetal outcomes of jaundice in pregnancy at the University College Hospital, Ibadan. Niger J Clin Pract. 2009;12(3):277-80.

Dsouza AS, Gupta G, Katumalla FS, Goyal S. Maternal and fetal outcome in liver diseases of pregnancy-A tertiary hospital experience. International Journal of Scientific and Research Publications. 2015;5(9).

Kumar A, Beniwal M, Kar P, Sharma JB, Murthy NS. Hepatitis E in pregnancy. Int J Gynecol Obstet India. 2004;7:11-5.

Reddy MG, Prabhakar GC, Sree V. Maternal and fetal outcome in jaundice complicating pregnancy. J NTR Univ Health Sci. 2014;3:231-3.

Acharya N, Acharya S, Shukla S, Athvale R. Study of Jaundice in Pregnancy. Glb J of Med research. 2013;13:25-9.