Study of relationship between umbilical cord blood hemoglobin percentage and perinatal asphyxia
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20204297Keywords:
Fetal asphyxia, Neurodevelopmental outcome, Umbilical cord blood haemoglobinAbstract
Background: Perinatal asphyxia may be caused by perinatal anemia. The pathophysiology and neurodevelopment effects are theoretically different from other causes of fetal asphyxia. Severe asphyxia can occur in infants around the time of birth by various reasons. The aim of this study to find the relationship between cord blood hemoglobin and perinatal asphyxia.
Methods: This was a retrospective comparative study in department of OBG In tertiary care health centre. Umbilical cord blood samples were collected from 100 newborns with asphyxia at birth as study group and 100 newborns with non asphyxia as control group. Hemoglobin was measured colorimetrically.
Results: This study finds that maximum number of patients in both the control and study group had hemoglobin in the range of 16.3-17.3 gm/dl. The difference was not statistically significant. P value>0.05.
Conclusions: Hematological changes observed early after delivery can determine the duration of hypoxemia (acute versus chronic) Perinatal anemia causing moderate to severe perinatal asphyxia is associated with a higher risk for neonatal mortality. All survivors with perinatal anemia, however, showed no abnormalities in neurodevelopment in contrast to children who were born asphyxiated due to various another causes. The underlying pathophysiological mechanism for the favorable NDO in the perinatal anemia group needs further elucidation.
References
Bracci R, Perrone S, Buonocore G. The timing of neonatal brain injury. Biol Neonate. 2006;90(3):145-55.
Curtin WM, Shehata BM, Khuder SA, Robinson HB, Brost BC. The feasibility of using histologic placental sections to predict newborn nucleated red blood cell counts. Obstet Gynecol. 2002;100:305-10.
Hajian-Tilaki K. Sample size estimation in epidemiologic studies. Caspian J Intern Med. 2011;2(4):289‐98.
Fahnenstich H, Dame C, Allera A, Rosskamo R, Kowalewski S. Erythropoetin as a biochemical parameter for fetal hypoxia. Klin pediatr. 1995;207:326-30.
Phelan JP, Ahn MO, Korst LM, Martin GI. Nucleated red blood cells: a marker of fetal asphyxia? Am J Obstet Gynecol. 1995;173:1380-4.
Morkos AA, Hopper AO, Deming DD, Yellon SM, Wycliffe N, Ashwal S, et al. Elevated total peripheral leukocyte count may identify risk for neurological disability in asphyxiated term neonates. J Perinatol. 2007;27(6):365-70.
Ghosh B, Mittal S, Kumar S, Dadhwal V. Prediction of perinatal asphyxia with nucleated red blood cells in cord blood of newborns. Int J Gynaecol Obstet. 2003;81:267-71.
Qaiser DH, Sandila MP, Kazmi T, Ahmed ST. Influence of maternal factors on hematological parameters of healthy newborns of Karachi. Pak J Physiol. 2009;5(2):34-7.
Boskabadi H, Mamouri GA, Sadeghian MH, Ghayour MM, Heydarzadeh M, Shakeri MT, et al. Early diagnosis of perinatal asphyxia by nucleated red blood cell count: a case-control study. Arch Iran Med. 2010;13(4):275-81.
Alam F, Aziz M, Ali SM, Hakim S, Afroz N. Evaluation of hematological profile of cord blood and placental histopathology in neonates with perinatal asphyxia. Curr Pediatr Res. 2012;16(2):105-10.
Puri S, Jindal K, Suri V, Puri G. Study of nucleated RBCs in cord blood of neonates with meconium stained amniotic fluid. Int J Adv Res. 2017;5:2205-9.
Darkhaneh RF, Asgharnia M, Yousefi TZ. Comparison of NRBC in term neonatal umbilical cord blood between neonates with meconium stained amniotic fluid and clear amniotic fluid. J Turkish-German Gynecol Assoc. 2008;9(2):29-31.
Brucknerova I, Ujhazy E, Dubovicky M, Mach M. Early assessment of the severity of asphyxia in term newborns using parameters of blood count. Interdisc Toxicol. 2008;1:211-3.
Pecháň I, Holomáň M, Záhorec R, Rendeková V, Gabauer I. Antioxidant vitamins and phosphocreatine as protective agents in cardiac surgery. Biochemical parameters. Cor Europe. 1996;5:69-73.
Holomáň M, Pecháň I. The protection of myocardium in cardiovascular surgery. Bratislava: ELÁN. 2002.
Holomáň M, Záhorec R, Rendeková V, Pecháň I. Vitamin E for skeletal muscle protection against reperfusion injury during elective revascularization surgery (biochemical and clinical assessment) Cor et Vasa. 1999;41:73-83.
Vento M, Asensi M, Sastre J, Lloret A, Garcia-Sala F, Vina J. Oxidative stress in asphyxiated term infants resuscitated with 100% oxygen. J Pediatr. 2003;142:240-6.
Shoji H, Koletzko B. Oxidative stress and antioxidant protection in the perinatal period. Curr Opin Clin Nutr Metab Care. 2007;10(3):324-8.
