Comparative study between intracytoplasmic morphologically selected sperm injection versus intracytoplasmic sperm injection in patients with severe male factor infertility and repeated intra cytoplasmic sperm injection failure

Yasser Ibrahim Orief, Mohamed Morad Elabd, Tamer Hanafy Mahmoud Said, Nesma Ahmed Abn Jad Ahmed


Background: The aim and objective of the study was to compare the results of IMSI and ICSI among infertile couples with severe male factor and repeated ICSI failure.

Methods: A comparative prospective randomized controlled study was carried out in Agial IVF/ICSI center, Alexandria with sample of one hundred and forty infertile couples with severe male factor and repeated ICSI failure using ICSI or IMSI with controlled ovarian hyper-stimulation. The main outcome measures were the chemical and clinical pregnancy rates.

Results: The couples were randomly subdivided equally into two groups: A, B, 70 underwent intra cytoplasmic morphologically selected sperm injection (IMSI) (group A) and 70 underwent intra cytoplasmic sperm injection (ICSI) (group B) treatment. In the IMSI group there were 19 (27.14%) women got pregnant and 51 (72.86%) did not got pregnant, while in the ICSI group, there were 14 (20.0%) got pregnant and 56 (80.0%) did not got pregnant. Using Pearson Chi-Square test there was no significant difference regarding chemical or clinical pregnancy between the two studied groups.

Conclusions: The use of IMSI was proved to be of no evident role in improvement of outcome of pregnancy rate in infertile couples with severe male factor and repeated ICSI failure, as analyzed data didn't show any significant difference.



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