Published: 2020-10-27

Assessment of socio-demographic and clinical factors associated with preeclampsia and eclampsia among primigravida attending tertiary care center in South India

Rency M. Jaboi, Vahitha S., Nivedita .


Background: The objective of the study was to identify the socio demographic and clinical factors associated with preeclampsia and eclampsia among primigravida attending a tertiary care center in South India.

Methods: A quantitative research approach with case control design was used. Non-probability convenience sampling was used to select two groups of primigravida mothers i.e. one group with 108 mothers having preeclampsia or eclampsia and one group with 108 mothers not having preeclampsia or eclampsia. A structured questionnaire was employed to collect the data.

Results: The study found that preeclampsia and eclampsia was significantly associated with maternal age (p=0.026), hemoglobin level (p=0.003), body mass index (p=0.001), weeks of gestation (p=0.016), age at menarche (p=0.003), age at first pregnancy (p=0.007), nutritional education (p=0.001), history of thyroid disorder (p=0.025), family history of hypertension (p=0.016), salt consumption (p=0.001), consumption of fried fatty food (p=0.008) and processed sugar (p=0.045), and intake of green leafy vegetables (p=0.001), pulses and beans(p=0.031) and activity (p=0.015). In the multiple regression analysis, body mass index (Adjusted Odds Ratio [OR] 2.28 [1.40-3.71] p=0.001), thyroid disorder (adjusted OR 2.756 [1.135-6.645] p=0.025) and intake of green leafy vegetables (adjusted OR 1.69 [1.223-2.360] p=0.002) were found to be independent risk factors associated with preeclampsia and eclampsia.

Conclusion: The study concluded that the risk factors should be identified and evaluated during the antenatal visits for early detection so as to reduce maternal and neonatal mortality.



Preeclampsia, Eclampsia, Primigravida, Clinical factors, Multiple logistic regression

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Fottrell E, Kanhonou L, Goufodji S, Béhague DP, Marshall T, Patel V et al. Risk of psychological distress following severe obstetric complications in Benin: the role of economics, physical health and spousal abuse. Br J Psychiatry. 2010;196:18-25.

Van den Broek NR, Falconer AD. Maternal mortality and Millennium Development Goal 5. Br Med Bull. 2011;99:25-38.

Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R. Pre-eclampsia. The Lancet. 2010;376:631-44.

Jeyabalan A. Epidemiology of preeclampsia: Impact of obesity. Nutr Rev. 2013;71:18-25

Dutta DC. Textbook of Obstetrics.7th ed. London. New Central Book Agency (P) Ltd. 2011;219-36.

Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. The Lancet. 2005;365:785-99.

Registrar General, India, Centre for Global Health Research, University of Toronto, Canada. Maternal mortality in India 1997-2003 Trends, causes and risk factors. New Delhi: Registrar General, India; 2006 Oct. Available from: Accessed on 14/7/2020.

Sajith M, Nimbargi V, Modi A, Sumariya R, Pawar A. Incidence of pregnancy induced hypertension and prescription pattern of antihypertensive drugs in pregnancy. Int J Pharm Sci Res. 2014;5:163-70.

Agrawal S, Walia G K. Prevalence and risk factors for Preeclampsia in Indian women: a national cross-sectional study. J Women’s Health. 2014;3:2-9.

Bygbjerg IC. Double burden of non-communicable and infectious diseases in developing countries. Science. 2012;337:1499-01.

Roberts JM. Medicine-Principles and Practice. Philadelphia: W.B. Saunders. Pregnancy-related hypertension. 1984:703-52.

Lee CJ, Hsieh TT, Chiu TH, Chen KC, Lo LM, Hung TH. Risk factors for pre-eclampsia in an Asian population. Int J Gynaecol Obstet. 2000;70:327-33.

Eskenazi B, Fenster L, Sidney S. A multivariate analysis of risk factors for preeclampsia. JAMA. 1991;266:237-41.

Mahomed K, Williams MA, Woelk GB, Jenkins-Woelk L, Mudzamiri S, Madzime S. Risk factors for preeclampsia-eclampsia among Zimbabwean women: Recurrence risk and familial tendency towards hypertension. J Obstet Gynaecol. 1998;18:218-22.

Kashanian M, Baradaran HR, Bahasadri S, Alimohammadi R, Razieh. Risk Factors for Pre-Eclampsia: A Study in Tehran, Iran. Arch Iran Med. 2011;14:412-5.

Ogawa K, Urayama KY, Tanigaki S, Sago H, Sato S. Association between very advanced maternal age and adverse pregnancy outcomes: a cross sectional Japanese study. BMC Pregnancy Childbirth. 2017;17:349.

Kawakita T, Wilson K, Grantz KL, Landy HJ, Huang CC, Gomez-Lobo V. Adverse Maternal and Neonatal Outcomes in Adolescent Pregnancy. J Pediatr Adolesc Gynecol. 2016;29:130-6.

Verma MK, Kapoor P, Yadav R, Manohar RK. Risk Factor Assessment for Preeclampsia: A Case Control Study. Int J Public Health. 2017;7:172-7.

Grum T, Hintsa S, Hagos G. Role of nutrition in the risk of preeclampsia. BMC Res Notes. 2018; 11: 683.

Frederick IO, Williams MA, Dashow E, Kestin M, Zhang C, Leisenring WM. Dietary fiber, potassium, magnesium and calcium in relation to the risk of preeclampsia. J Reprod Med. 2005;50:332-44.

Motedayen M, Rafiei M, Tavirani MR, Sayehmiri K, Dousti M. The relationship between body mass index and preeclampsia: A systematic review and meta-analysis. Int J Reprod BioMed. 2019;17:463-72.

Sardana D, Nanda S, Kharb S. Thyroid hormones in pregnancy and preeclampsia. J Turkish-German Gynecol Assoc. 2009;10:168-71.

Agrawal S. Frequency of consumption of specific food items and symptoms of preeclampsia and eclampsia in Indian women. Int J Med Public Health. 2014;4:350-53.