DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20203867

Study of malignant tumours of the uterine corpus: histopathology and immunohistochemistry

Zahida O. A., Mohammad Niaz, Krishnaraj Upadhyaya

Abstract


Background: The uterine corpus represents the second most common site for malignancy in the female genital tract. This study was performed to ascertain the profile of malignant tumours of the uterine corpus reported at our centre.

Methods: A retrospective analysis of cases retrieved from the archives of the department of pathology from January 2014 to December 2016. Clinical information of the patients was collected from the hospital records.  Classification and grading of the tumours were done according to the current WHO classification.

Results: Nineteen cases were studied. There were ten cases of endometrial adenocarcinoma, five cases of leiomyosarcoma, three cases of endometrial stromal sarcoma and one case of carcinosarcoma(malignant mixed mullerian tumour). The age range of endometrial adenocarcinoma was 55 to 85 years and presented with post menopausal bleeding, whereas endometrial stromal sarcomas occurred in women above 45 years of age. Leiomyosarcomas had age range from 26 to 65 years. All leiomyosarcomas were clinically diagnosed as fibroid. Majority of endometrial adenocarcinomas were well differentiated endometroid type. Out of the three endometrial stromal sarcomas two were high grade, one with metastasis. All leiomyosarcomas showed mitotic rate above 10/10hpf.

Conclusions: Endometrial carcinomas form the majority of malignant tumours of uterine corpus and occur in older age group followed by leiomyosarcomas. Endometrial stromal sarcomas are less common and occur in middle aged and older patients. Leiomyosarcomas and stromal sarcomas are usually misdiagnosed as fibroids clinically unless metastases are present.


Keywords


Uterine corpus, Endometrial carcinomas, Carcinosarcoma

Full Text:

PDF

References


Torre L, Bray F, Siegel R, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. Cancer Journal for Clinicians. 2015;65(2):87-108.

Globocan Available at: http://globocan.iarc.fr. Accessed on 25 May 2020.

Kurman RJ, Carcangiu ML, Herrington CS, Young RH. WHO Classification of tumours of female reproductive organs. 4th ed. France: IARC Press; 2014.

Nkyekyer K. Pattern of gynecological cancers in Ghana. East Afr Med J.2000;77:534-8.

Rosai J. Rosai and Ackerman's Surgical Pathology. 10th ed. London: Elsevier Health Sciences; 2011: 1490-1521.

Benediktsdóttir K, Jónasson J, Hallgrímsson J. Tumours in Iceland. Malignant tumours of the corpus of the uterus. APMIS. 1989;97(7-12):781-6.

Tan YY, Ho TH. Uterine cancer--KK Hospital experience. Singapore Med J. 1996;37(6):600-3.

Chang KL, Crabtree GS, Lim-Tan SK, Kempson RL, Hendrickson MR. Primary uterine endometrial stromal neoplasm. A clinicopathological study of 117 cases. Am J Surg Pathol. 1990;14(5):415-38.

De Fusco PA, Gaffey TA, Malkasian GD, Long HJ, Cha SS. Endometrial stromal sarcoma: review of Mayo Clinic experience, 1945-1980. Gynecol Oncol. 1989;35(1):8-14.

Arya A, Narula R, Narula K, Singh S. Retrospective and prospective study of benign and malignant uterine corpus tumours. National Journal of Integrated Research in Medicine. 2013;4(6):5-10.

Hemalatha A, Gayathri M, Ramesh D, Chamarthy N, Giripunja M, Nayana N. Evaluation of trends in the profile of gynaecologic malignancies at a tertiary care hospital in Karnataka, South India. Intenat J of Med Res & Health Sci. 2013;2(4):870.

N’Dah KJ, Doukoure B, Troh E, Aman NA, Koffi, KE, Kouamé AD, et al. Epidemiological and Histological Aspects of Women Genital Cancers in Côte d’Ivoire. Open Journal of Obstetrics and Gynecology. 2014;4:516-23.