Evaluation of the effects of radiotherapy as a mode of treatment in management of advanced cancer cervix

Rajeshwari BV


Background: Throughout world over 500000 new cases of invasive cancer cervix are detected each year and account for 15% of new cancer and 200000 deaths annually. In India more than 90,000 women suffer annually from cervical cancer and mortality of them report in advanced stage of disease.

Methods: All cases were investigated with routine hematological and biochemical examination, x-ray chest, and ultrasonography of the abdomen and pelvis before starting radiotherapy treatment. All patients were examined and staged clinically according to the International Federation of gynaecologists and Oncologists (FIGO) staging system.

Results: Majority of the patients 50% were in stage III B, followed by stage III A about 21% and 20% in stage IIB. During follow up, in study group maximum number of patients about 76% presented with skin changes like dryness, erythema, discoloration, diarrhea in 40%, obstructive uropathy in 16%, and in 4% developed vaginal stenosis.

Conclusions: Today, malignancy is the challenge not only to the gynecologist, radiation oncologist but also to the patient. But because of newer technique and advances in medical field update in infrastructure gives to the specialist new dimension to treat the patient as well as raise of hopes to the patient.


Cancer cervix, Chemotherapy, Radiotherapy

Full Text:



Saibishkumar EP, Patel FD, Sharma SC. Evaluation of late toxicities of patients with carcinoma of the cervix treated with radical radiotherapy: An audit from India. Clin Oncol (R Coll Radiol). 2006;18:30-7.

Pisani P, Parkin DM, Bray, Ferlay T. Estimates of worldwide mortality from 25 Cancers in 1990. Int J Cancer. 1999;83:18-29.

Laara P. Changing Trends in epidemiology of Carcinoma cervix. Contribution to Obstetric Gynec. 1988;5:235.

Bloomfield GW. The treatment of cancer uterine cervix by radium x-ray therapy. Br J of Radiology. 1961;34:755.

Nag S, Erickson B, Thoadson B, Orlon C Damanes J D, Petereit D. the American Brachytherapy society recommendation for high dose rate brachy for ca cx. Int J Radiat Oncol Biol Physol. 2000:48:201-11.

Parkin DM, Bray, Plsani P, Ferlay J. Estimating the world cancer burden: Globocon 2000. Int J Cancer. 2001;94:153-6.

Morley GW, Lindeaure SM, Pelvic exenterative therapy for Gynecologic malignancy an analysis of 70 cases. Cancer. 1976;38(1):581-6.

Byckley CH, Beard CS, Fox H. Pathologic prognostic indicators in cervical cancer with particular reference to age under 40 years. Br J .of Obstetrics and Gynecology. 1988;95:47-56.

Kjorstad K. Carcinoma of the cervix in young patients Obstet and Gynecol. 1977;50(1):28-30.

Perez CA, Grigsby PW. Adjuvant chemotherapy and irradiation in locally advanced squamous cell carcinoma of the uterine cervix. PPGO Updates. 1993;1(4):1-20

Kottmeir HL. Complications following radiation therapy of carcinoma of cervix and their treatment. Am J Obstet and Gynecol. 1964;88:854.