Sildenafil citrate to improve colour doppler indices in patient with pre-eclampsia: a path less taken


  • Priyanka H. Vora Department of Reproduction, Ankoor Fertility Clinic, Mumbai, Maharashtra, India
  • Rana A. Choudhary Department of Reproduction, Ankoor Fertility Clinic, Mumbai, Maharashtra, India
  • Kedar N. Ganla Department of Reproduction, Ankoor Fertility Clinic, Mumbai, Maharashtra, India



Vaginal sildenafil citrate, Preterm, Pregnancy induced hypertension, Absent end diastolic flow, Colour doppler indices


Presented a case of high-risk pregnancy of an elderly primigravida who had abnormal colour doppler indices. Addition of sildenafil citrate lead to improvement of colour doppler indices and growth parameters, thus prolonging the period of gestation by 6 weeks. This led to decreased neonatal ICU stay and reduction in neonatal morbidity.


Dastjerdi MV, Hosseini S, Bayani L. Sildenafil citrate and uteroplacental perfusion in fetal growth restriction. J Res Med Sci. 2012;17(7):632-6.

Anwar MHH, Hasanin MK, Abdelaziz BR, Ismail Hamd OAM. Effect of Sildenafil Citrate on Fetal Color Doppler Study and Biophysical Profile in Cases of Intrauterine Growth Restriction (IUGR) in Third Trimester. Egyp J Hospital Med. 2018;72(11):5571-4.

Ganla KN, Choudhary RA, Desai KN, Kadam SB, Arunachalam K. A retrospective interventional study for evaluation of efficacy and safety of sildenafil citrate in improving intrauterine growth restriction and oligohydramnios using ultrasound Doppler velocimetry. Int J Basic Clin Pharmacol. 2019;8(12):2736-40.

Usha K, Sarita B. Placental Insufficiency and Fetal Growth Restriction. J Obstet Gynecol India. 2011;61(5):505-11.

Samangaya RA, Mires G, Shennan A, Skillern L, Howe D, McLeod A et al. A randomised, double-blinded, placebo-controlled study of the phosphodiesterase type 5 inhibitor sildenafil for the treatment of preeclampsia. Hypertens Preg. 2009;28:369-82.

Premalatha HL, Raghupathi KMS, Srinivas DNB, Venkatesh, Laxmi kanth. Study of effect of sildenafil citrate in pregnant women with intrauterine growth restriction/oligohydramnios. Int J Reprod Contracept Obstet Gynecol. 2016;5(9):3094-7.

Farooq SU, Mir SA, Kareem O, Rashid R, Ara R, Bader GN. Sildenafil Citrate in Management of Intrauterine Growth Restriction: A Case Study. J Gynecol Wom Heal. 2019:15(2):555910.






Case Reports