DOI: https://dx.doi.org/10.18203/2320-1770.ijrcog20160877
Published: 2016-12-27

Histopathological pattern of endometrium in abnormal uterine bleeding of perimenopausal women

Bharat Talukdar, Rashmi Rekha Goswami, Sangita Mahela, Noor Islam Ahmed

Abstract


Background: The aim of the study was to evaluate the histopathological pattern of endometrium in perimenopausal women presenting with abnormal uterine bleeding.

Methods: This prospective study was carried out from June 2014 to May 2015 in a tertiary care teaching hospital on 180 number of perimenopausal women who presented with abnormal uterine bleeding.

Results: Most of the patients were between 40-45 years of age (63.89%) and menorrhagia was the dominant clinical presentation 80 (44.44%). The commonest pathology was hyperplasia in 83 (46.11%) women with simple hyperplasia without atypia being the predominant pattern (65 cases) which was most commonly seen between 40 and 45 years of age. Atrophic endometrium was the common pattern in age group of ˃ 50 years. Other pathology identified were proliferative endometrium (20.56%), secretory endometrium (16.11%), endometritis (2.22%), endometrial polyp (2.22%), pregnancy related (2.22%) and carcinoma (1.11%).

Conclusions: Histopathological pattern of the endometrium in abnormal uterine bleeding in perimenopausal women should be studied especially to rule out preneoplasia and malignancy.


Keywords


Abnormal uterine bleeding, Perimenopause, Menorrhagia, Endometrium

Full Text:

PDF

References


Munro GM, Critchley ODH, Fraser SI. FIGO Menstrual Disorders Working Group. The FIGO classification of causes of abnormal uterine bleeding in the reproductive years. Fertil Steril. 2011;95:2204-8.

Kumar P, Malhotra N. Clinical types of abnormal uterine bleeding. In: Kumar, eds. Jeffcoate’s Principle of Gynecology. 7th ed. New Delhi: Jaypee Brothers Medical Publishers (P) Ltd. 2008:599.

Munro GM, Critchley ODH, Fraser SI. The FIGO systems for nomenclature and classification of causes of abnormal uterine bleeding in the reproductive years: who needs them? AJOG. 2012;207(4):259-65.

Mahajan N, Aggarwal M, Bagga A. Health issues of menopausal women in North India. J Midlife Health. 2012;3:84-7.

Jetley S, Rana S, Jairajpuri ZS. Morphological spectrum of endometrial pathology in middle aged women with atypical uterine bleeding - a study of 219 cases. J Midlife Health. 2013;4:216-20.

Shobha PS. Sonographic and histopathological correlation and evaluation of endometrium in perimenopausal women with abnormal uterine bleeding. Int J Reprod Contracept Obstet Gynaecol. 2014;3(1):113-7.

Kathuria R, Bhatnagar B. Correlation between D&C, USG and hysteroscopy findings in diagnosing a cause for abnormal uterine bleeding. Indian Journal of clinical practice. 2014;25(5):466-70.

Ghani NA, Abdulrazak AA, Abdullah EM. Abnormal Uterine Bleeding: a Histopathological Study. Diyala Journal of Medicine. 2013;4(1):56-60

Dangal G. A study of endometrium in patients with abnormal uterine bleeding at Chitwan valley. Kathmandu University Medical Journal. 2003;1(2):110-2.

Sloboda L, Molnar E, Popovic Z, Zivkovic S. Analysis of pathohistological results from the uterine mucosa 1965-98 at the gynecology department in Senta. Med Pregl. 1999;52(6-8):263-5.

Khare A. Morphological spectrum of endometrium in patients presenting with dysfunctional uterine bleeding. Peoples’s Journal of scientific research. 2012;5(2):13-6.

Doraiswami S, Johnson T, Rao S, Rajkumar A, Vijayaraghavan J, Panicker VK. Study of endometrial pathology in abnormal uterine bleeding. J of Obstet & Gynae of India. 2011;61(4):426-30.

Damle RP, Dravid NV, Suryawanshi KH, Gadre AS, Bagale PS, Ahire N. Clinicopathological spectrum of endometrial changes in perimenopausal& menopausal uterine bleeding. J of clinical & Diagnostic Research. 2013;7(12):2774-6.

Bhatta S, Sinha AK. Histopathological study of endometrium in abnormal uterine bleeding. J of Pathology Nepal. 2012;2(4):297-300.

Patil R, Patil RK, Andola SK, et al. Histopathological spectrum of endometrium in dysfunctional uterine bleeding. Int J Bio Med Res. 2013;4(1): 2798-801.

Ara S, Roohi M. Abnormal uterine bleeding; histopathological diagnosis by conventional dilatation and curettage. Prof Med J. 2011;18:587-91.

Jairajpuri ZS, Rana S, Jetley S. Atypical uterine bleeding - Histopathological audit of endometrium - A study of 638 cases. Al Ameen J Med Sci. 2013;6(1):21-8.

Abdullah LS, Bondagji NS. Histopathological Pattern of Endometrial Sampling Performed for Abnormal Uterine Bleeding. Bahrain Med Bull. 2011;33:1-6.

Mirza T, Akram S, Mirza A, et al. Histopathological Pattern of Abnormal Uterine Bleeding in Endometrial Biopsies. J Basic Applied Sci. 2012;8:114-7.

Khan S, Hameed S, Umber A. Histopathological pattern of endometrium on diagnostic d&c in patients with abnormal uterine bleeding. Annals. 2011;17:166-70.