Uterine artery Doppler in first trimester in prediction of adverse pregnancy outcome in Dharmapuri district of Tamil Nadu


  • Bindu S. Department of Obstetrics and Gynecology, Government Dharmapuri Medical College, Dharmapuri, Tamil Nadu, India




Uterine artery Doppler abnormality, Gestational Hypertension, First trimester


Background: Pregnancies are complicated by hypertensive disorders of about 5-10% and hemorrhage, sepsis, and fetal growth restriction constitute a triad contributing to maternal morbidity and mortality. Hypertensive disorders in pregnancy vary from mildly elevated blood pressure to severe hypertension with multi-organ dysfunction. The study aims to evaluate the first-trimester uterine artery Doppler in the prediction of the development of adverse pregnancy outcomes.

Methods: This prospective longitudinal observational was done in Dharmapuri Medical College and Hospital were selected for this study. Totally 150 pregnant women were included in the study. 75 were controls and 75 cases. The study period was from June 2018 to February 2019. Evaluating the optimal definition of abnormal first trimester.

Results: Previous obstetric history in the study population. In the study group 3% of bad obstetric history (BOH) present. In the case group, 5% has BOH due to 2 neonatal death and 2 term intrauterine device (IUD), uterine artery Doppler parameters to predict adverse pregnancy outcomes, and association of gestational hypertension in the study groups. In the control group, 1%, and the case group 5% of them had gestational hypertension. Out of 4, 3 had an average uterine artery Doppler more than 2.3 (maximum of 2.7) and 1 had single uterine artery Doppler abnormality.

Conclusions: The study showed that first-trimester uterine artery Doppler with single and average uterine artery pulsatility index (PI) >95th centile (2.3) has a better screening value in my population. The overall performance of the first-trimester uterine artery Doppler in the prediction of adverse pregnancy outcomes is valuable.

Author Biography

Bindu S., Department of Obstetrics and Gynecology, Government Dharmapuri Medical College, Dharmapuri, Tamil Nadu, India



Adelusi B, Ojengbede OA. Reproductive performance after eclampsia. Int J Gynaecol Obstet. 2016;24:183-9.

Alessia M, Sahina C, Alessandro C. Hypertensive disorders of pregnancy. J Prenat Med. 2009;3(1):1-5.

Bainbridge SA, Sidle EH, Smith GN. Direct placental effects of cigarette smoke protect women from pre-eclampsia: the specific roles of carbon monoxide and antioxidant systems in the placenta. Med Hypotheses. 2005;64:17-27.

Barton J, Sibai B. Prediction and prevention of recurrent preeclampsia. Obstet Gynecol. 2008;112(2):359-72.

Berg CJ, Harper MA, Atkinson SM, Bell EA, Brown HL, Hage ML, et al. Preventability of pregnancy-related deaths: results of a state-wide review. Obstet Gynecol. 2005;106:1228-34.

Buchbinder A, Sibai BM, Caritis S, Macpherson C, Hauth J, Lindheimer MD, et al. Adverse perinatal outcomes are significantly higher in severe gestational hypertension than in mild preeclampsia. Am J Obstet Gynecol. 2002;186(1):66-71.

Crispi F, Dominguez C, Llurba E, Martin-Gallan P, Cabero L, Gratacos E. Placental angiogenic growth factors and uterine artery Doppler findings for characterization of different subsets in preeclampsia and isolated intrauterine growth restriction. Am J Obstet Gynecol. 2006;195:201-7.

Dildy GA, Belfort MA, Smulian JC. Preeclampsia recurrence and prevention. Semin Perinatol. 2007;31(3):135-41.

Duckitt K, Harrington D. Risk factors for pre-eclampsia at antenatal booking: Systemic review of controlled studies. BMJ. 2005;330(7491):565.

Furuya M, Ishida J, Aoki I, Fukamizu A. Pathophysiology of placentation abnormalities in pregnancy-induced hypertension. Vasc Health Risk Manag. 2008;4(6):1301-13.

Gardosi J, Kady SM, McGeown P, Francis A, Tonks A. Classification of stillbirth by relevant condition at death (ReCoDe): a population-based cohort study. BMJ. 2005;331:1113-7.

Goldenberg RL, Mercer BM, Moawad A, Thom E, Meis PJ, et al. The Preterm Prediction Study: recurrence risk of spontaneous preterm birth. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J Obstet Gynecol. 1998;178(5):1035-40.

Hauth JC, Ewell MG, Levine RJ, Esterlitz JR, Sibai B, Curet LB, et al. Pregnancy outcomes in healthy nulliparas who developed hypertension. Calcium for Preeclampsia Prevention Study Group. Obstet Gynecol. 2000;95(1):24-8.

Hutcheon JA, Lisonkova S, Joseph KS. Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy. Best Pract Res Clin Obstet Gynecol. 2011;25(4):391-403.

Kassebaum NJ, Bertozzi-Villa A, Coggeshall MS, Shackelford KA, Steiner C, Heuton KR, et al. Global and regional and national levels and causes of maternal mortality during 1990-2013: a systemic analysis for the global burden of disease study 2013. Lancet. 2014:384:980-1004.

Khan KS, Wojdyla D, Say L, Gülmezoglu AM, Van Look PF. WHO analysis of causes of maternal death: a systematic review. Lancet. 2006;367:1066-74.

Mc Donald SD, Best C, Lam K. The recurrence risk of severe de novo pre-eclampsia in singleton pregnancies: a population-based cohort. BJOG. 2009;116(12):1578.

Costello D, Kallogjeri D, Tungsiripat R, Leet T. Recurrence of preeclampsia: effects of gestational age at delivery of the first pregnancy, body mass index, paternity, and the interval between births. Am J Obstet Gynecol. 2008;199:55.

O’Brien TE, Ray JG, Chan WS. Maternal body mass index and the risk of pre-eclampsia: a systemic overview. Epidemiology. 2003;14(3):368-74.

Prakash J, Pandey LK, Singh AK, Kar B. Hypertension in pregnancy: a hospital-based study. J Assoc Physicians India. 2006;54:273-8.






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