A cross-sectional study to find the prevalence of hyperprolactinemia in infertile euthyroid patients in a hospital
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20204429Keywords:
Infertility, Hyperprolactinemia, EuthyroidAbstract
Background: Infertility whether primary or secondary, has multi-factorial causation, out of which hormonal imbalance is one of the important factors. Current study evaluates the prevalence of hyperprolactinemia in infertile euthyroid women.
Methods: After Ethics Committee approval and written informed consent, all infertile euthyroid women (n=153) with age group 20-40 years attending outpatient department of general hospital, with marriage duration of at least one year and willing to participate in study were recruited. Male factor infertility, women with diagnosed hyperprolactinemia, thyroid abnormality, tubal factors, any congenital anomaly of urogenital tract or obvious organic lesion or with history of anxiety or other psychological disorders and on treatment for same were excluded. Detailed obstetrics history with relevant laboratory, radiological investigations including serum prolactin level was done.
Results: Mean serum prolactin level was 13.89±10.03 ng/ml. Out of 153 participants, 13 had hyperprolactinemia which comprised 8.50% of the sample. The mean of the level of serum prolactin level in primary infertility cases was 13.18±8.485 ng/ml while that in secondary infertility was 17.21±15.1 ng/ml. Primary infertility was approximately half (53.85%) in hyperprolactinemia group and majority (85%) in normoprolactinemia group. Duration of married life, infertility and fasting blood sugar were positively correlated with prolactin levels.
Conclusions: Prevalence of hyperprolactinemia was 8.50% with higher serum prolactin level in secondary infertility as compared to primary infertility. So, estimation of serum prolactin levels in infertile patients with euthyroid status can help to a large extent in finding the cause of infertility and may help in further management.
References
Zegers-Hochschild F, Adamson GD, de Mouzon J, Ishihara O, Mansur R, Nygren K, et al. International committee for monitoring assisted reproductive technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology. Fertil Steril. 2009;92(5):1520-4.
Global status report on noncommunicable diseases 2014. Available at: http://www.who.int/nmh/ publications/ncd-status-report-2014/en/. Accessed on 20 August 2020.
National Family health survey, India. Available at: http://rchiips.org/NFHS/factsheet_NFHS-4.shtml. Accessed on 20 August 2020.
Osman AA. Management of infertility within primary health care program in Sudan. Asian
J Sci Res. 2011;4(2):158-64.
Turankar S, Sonone K, Turankar A. Hyperprolactinaemia and its comparision with hypothyroidism in primary infertile women. J Clin Diagn Res. 2013;7(5):794-6.
Nallusamy S, Gracelyn LJ. Prevalence of hyperprolactinemia in infertile women and its association with hypothyroidism. Int J Adv Med. 2016;3(1):33-8.
Davis LB, Lathi RB, Dahan MH. The effect of infertility medication on thyroid function in hypothyroid women who conceive. Thyroid. 2007;17:773-7.
Poppe K, Velkenier B, Glinoer D. Thyroid disease and female reproduction. Clin Endocrinol (Oxf). 2007;66:309-21.
Onal ED, Saglam F, Sacikara M, Ersoy R, Cakir B. Thyroid autoimmunity in patients with hyperprolactinemia: An observational study. Arq Bras Endocrinol Metabol. 2014;58:48-52.
Wang AT, Mullan RJ, Lane MA, Hazem A, Prasad C, Gathaiya NW, et al. Treatment of hyperprolactinemia: A systematic review and meta-analysis. Syst Rev. 2012;1:33.
Kaiser UB. Hyperprolactinemia and infertility: new insights. J Clin Invest. 2012;122(10):3467-8.
Goswami B, Patel S, Chatterjee M , Koner BC, Saxena A. Correlation of Prolactin and Thyroid hormone concentration with menstrual patterns in Infertile women. J Reprod Infertil. 2009;10(3):207-12.
Tasneem A, Fatima I, Ali A, Mehmood N, Amin MK. The incidence of hyperprolactinaemia and associated hypothyroidism: local experience from Lahore. Pak J Nucl Med. 2011;1:49-55.
Hooja N, Fatima A, Mital P, Singh N, Gothwal S, Aseri S, et al. Correlation of prolactin and thyroid hormone levels in infertile women. Sch Acad J Biosci. 2015;3(1A):1-2.
Sharma P, Prasad S, Tangri N. Female infertility and its correlation with serum prolactin and TSH concentration- an unmatched case control study. J Pharm Biomed Sci. 2013;30(30):902-7.
Akhter N, Hassan S. Sub-clinical hypothyroidism and hyperprolactinemia in infertile women: Bangladesh persepective after universal salt iodination. Int J Endocrinol. 2008;5:1-8.
