DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20205274

Systemic lupus erythematosus-a good maternal and fetal outcome

Preeti Lewis, Ashrulina Pal

Abstract


Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease which primarily affects women in their reproductive years. The fertility is generally unaffected except in women with active disease, significant impairment of renal function, or high dose corticosteroid or cyclophosphamide therapy, which can result in ovarian dysfunction. This case report elaborates on the course of the pregnancy and the favourable maternal and fetal obstetric outcome of a 28-year-old female with known case of hypothyroidism who presented with chief complaints of generalised swelling all over the body and exertional dyspnoea and was later diagnosed to be a case of focal proliferative lupus nephritis, class III (ISN/RPS) on renal biopsy done postpartum. The effect of pregnancy on maternal disease is controversial. While some studies report exacerbation of SLE during pregnancy,others have not reported increased flares. The only study on this aspect of SLE from our country did not report a flare-up of disease during pregnancy.


Keywords


SLE, Hypothyroidism, Cyclophosphamide, Focal proliferative lupus nephritis, Class III (ISN/RPS)

Full Text:

PDF

References


Lockshin MD, Reinitz E, Druzin ML, Murrman M, Estes D. Lupus pregnancy: case-control prospective study demonstrating absence of lupus exacerbation during or after pregnancy. Am J Med. 1984;77(5):893-8.

Urowitz MB, Gladman DD, Farewell VT, Farewell VT, Stewart J, McDonald J. Lupus and pregnancy studies. Arthritis Rheum. 1993;36(10):1392-7.

Ruiz-Irastorza G, Lima F, Alves J, Simpson J, Hughes GR, Buchanan NM. Increased rate of lupus flare during pregnancy and the puerperium: a prospective study of pregnancies. Br J Rheumatol. 1996;35(2):133-8.

Mok CC, Wong RWS. Pregnancy in systemiclupus erythematosus. Postgrad Med J. 2001;77:157-65.

Petri M, Howard D, Repke J. Frequency of lupus flarein pregnancy. The Hopkins Lupus Pregnancy Center experience. Arthritis Rheum. 1991;34:1538-45.

Aggarwal N, Sawhney H, Vashishta K, Chopra S. Bambery Pregnancyin patients with systemic lupus erythematosus. Aust NZ J Obstet Gynaecol. 1999;39:28-30.

Buyon JP, Kalunian KC, Ramsey-Goldman R, Petri MA, Lockskin MD, Ruiz-Irastorza G et al. Assessing disease activity in SLE patients during pregnancy. Lupus. 1999;8:677-84.

Petri M. Systemic lupus erythematosus: Women’s health issues. Bull Rheum Dis. 2000;49:1-3.

Guballa N, Sammaritano L, Schwartzmann S, Buyon J, Lockshin MD. Ovulation Induction and in vitro fertilizationin systemic lupus erythematosus and antiphospholipid syndrome. Arthritis Rheum. 2000;43:550-6.

Martinez-Rueda JO, Arce-Stalinas CA, Kraus A, Alcocer-Varela J, Alarcón-Segovia D. Factors associated with fetal losses in severe systemic lupus erythematosus. Lupus. 1996;5:113-9.