COVID-19 symptoms-does pregnancy alter the course of the disease

Sabnam S. Nambiar, Reshmi V. P., Ajith S.


Background: COVID-19 or corona virus 2 is a widespread pandemic taking a huge toll on the world has a varied presentation in different age groups. Similarly, it has a poorer outcome in the elderly with various comorbidities and those who are immunocompromised. Though pregnancy is a relatively immunocompromised state studies have found that pregnant women have a less severe presentation. We have tried to assess this aspect of COVID-19 in pregnant women.

Methods: We evaluated the records of 158 pregnant women who presented to our hospital from April 2020 till September 2020.Their symptoms at presentation were evaluated. we also noted the outcome of these pregnancies.

Results: 16% of these were more than 34 weeks of period of gestation. 65.19% presented without any symptoms. 15.19% presented with fever. 10.75% presented with cough. 8.22% presented with headache. 5.69% presented with sore throat alone. 3.16% presented with breathlessness. 0.63% presented with anosmia alone, loss of taste, severe acute respiratory infection, vomiting, sore throat and breathlessness respectively. 54 patients delivered of which 7 delivered vaginally and there were 47 caesareans. Remaining patients after cure were discharged. There were 3 miscarriages. Two babies were found to be COVID-19 positive from nasopharyngeal swab taken on day 1, however this was a small number to indicate vertical transmission.

Conclusion: Our study showed that a large proportion of pregnant patients presented without remains to be evaluated why this is may provide us with clues on how to deal with disease in the general population.


COVID-19, Pregnancy, Fever, Symptoms, Cough, Sore throat, Anosmia, Diarrhoea

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Hui DS, Azhar E, Madani TA, Ntoumi, Kock R, Dar O, et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health: the latest 2019 novel coronavirus outbreak in Wuhan China. Int J Infect Dis. 2020;91:264-6.

WHO Director general’s opening remarks at the media briefing on covid 19. World health organization press release. Available at: Accessed on 12 March 2020.

COVID-19 dashboard by the centre for systems science and engineering (CSSE) at johns Hopkins. Available at: COVID-19. Accessed on 12 March 2020.

Symptoms of corona virus. U S Centre for disease control and prevention (CDC). Available at: Accessed on 14 April 2020.

Q and A on corona virus (COVID-19). World health organization archived from the original. Available at: Accessed on 11 March 2020.

Q and A on coronaviruses. World health organization (who) archived from the original on 20 Jan 2020. Available at: Accessed on 16 April 2020.

European Centre for Disease Prevention and Control. Q and A on COVID-19. Available at: Accessed on 30 April 2020.

Salehi S, Abedi A, Balakrishnan S, Gholamrezanezhad A. Coronavirus disease 2019 (COVID-19): a systematic review of imaging findings in 919 patients. Am J Roentgenol. 2020:1-7.

American College of Radiology. ACR recommendations for the use of chest radiography and computed tomography (CT) for suspected COVID-19 infection. ACR website. Available at: dvocacy-and Economics/ACR-Position-Statements/Recommenda tions-for-Chest-Radiography-and-CTfor-Suspected-COVID19-Infection. Accessed on 11 March 2020.

Omrani AS, Saad MM, Baig K, Bahloul A, Abdul-Matin M, Alaidaroos AY. Ribavirin and interferon alfa-2a for severe middle east respiratory syndrome coronavirus infection: a retrospective cohort study. Lancet Infect Dis. 2014;14(11):1090-95.

Payne DC, Iblan I, Alqasrawi S, Nsour MA, Rha B, Tohme RA. Stillbirth during infection with middle east respiratory syndrome coronavirus. J Infect Dis. 2014;209:1870-72.

Malik A, El Masry KM, Ravi M, Sayed F. Middle east respiratory syndrome coronavirus during pregnancy, Abu Dhabi, United Arab Emirates. Emer Iinfect Dis. 2013;2016(22):515-7.

Vasylyeva O. Pregnancy and COVID-19, a brief review. Int J Integr Pediatr Environ Med. 2020;5(1):8-13.

Ge XY, Li JL, Yang XL, Chmura AA, Zhu G, Epstein JH. Isolation and characterization of a bat SARS-like coronavirus that uses the ace2 receptor. Nature. 2013;503(7477):535-8.

Letko M, Marzi A, Munster V. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B beta corona viruses. Nature Microbiol. 2020;5(4):562-9.

Zhang H, Penninger JM, Li Y, Zhong N, Slutsky AS. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intens Care Med. 2020;46(4):586-90.

Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Inter J Oral Sci. 2020;12(1):8.

Verdecchia P, Cavallini C, Angeli F. The pivotal link between ACE2 deficiency and SARS-COV2 infection. Eur J Intern Med. 2020.

Allotey J, Stallings E, Bonet M, Yap M, Chatterjee S, Kew T, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. Brit Med J. 2020;370.

Chen H, Guo J, Wang C. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;805.

Irani R, Xia Y. Renin angiotensin signalling in normal pregnancy and preeclampsia. Semin Nephrol. 2011;31(1):47-58.