Amniotic fluid optical density at spontaneous onset of labour and it’s correlation with gestational age, birth weight and functional maturity of newborn
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20205247Keywords:
AFOD, Functional maturity, Respiratory distressAbstract
Background: Respiratory distress is the common cause of neonatal morbidity and mortality. Babies born even at 40 weeks of gestation developed respiratory distress. The maturity of newborn is independent of gestational age and birth weight of newborn. In this study amniotic fluid optical density (AFOD) is correlated with the functional maturity of newborn.
Methods: In this study, hundred singleton pregnant women who underwent first trimester scan and crown rump length estimation, and who were on spontaneous labor were selected for this observational study. Under aseptic precautions AF samples were collected while doing amniotomy with 2 ml disposable syringe, also collected during caesarean section after careful hysterotomy from the bulging membranes. Amniotic fluid optical density studied with spectrometer at 650 nm. Birth weights were recorded for all the babies. Babies are also looked for the respiratory distress, NICU admission.
Results: In this study, respiratory distress was reported in 28% of newborns whereas 72% of newborns did not have distress. In the present study, 27% of newborns were admitted in NICU where as 73% of the newborns were on mother’s side following delivery. Babies with AFOD 0.98±0.27 were functionally mature, skin was pleased brown in colour with little vernix, none of them had respiratory distress. Amniotic fluid optical density <0.4 developed respiratory distress.
Conclusions: Amniotic fluid optical density is a simple method to assess the functional maturity of newborn.
References
Tsao FH, Zachman RD. Use of quantitative amniotic fluid phosphatidylglycerol as a criterion for fetal lung maturation. Am J Perinatol. 1992 Jan;9(01):34-7.
Dubin SB. The laboratory assessment of fetal lung maturity. Am J Clin Pathol. 1992;97(6):836-49.
Hagen ED, Link JC, Arias FE. A comparison of the accuracy of the TDx-FLM assay, lecithin-sphingomyelin ratio, and phosphatidylglycerol in the prediction of neonatal respiratory distress syndrome. Obstet Gynecol. 1993;82(6):1004-8.
Ruch AT, Lenke RR, Ashwood ER. Assessment of fetal lung maturity by fluorescence polarization in high-risk pregnancies. J Reprodu Med. 1993;38(2):133-6.
Fakhoury G, Daikoku NH, Benser J, Dubin NH. Lamellar body concentrations and the prediction of fetal pulmonary maturity. Am J Obstet Gynecol. 1994;170(1):72-6.
Salmona M, Diomede L, Moro G, Minoli I, Bernini S, Agosti S. Fetal lung maturity evaluation with fluorescence polarization of the amniotic fluid. Jo Perinat Med. 1993;21(5):349-54.
Popkin DR, Peddlr LJ. Women’s Health Today- Perspectives on current research and Clinical Practice: The proceedings of XIV World congress of Obstetrics and Gynecology. In: Impact of Imaging in Obstetrics and Gynecology- Prediction of birthdate and newborns state. 1st edn. New York: Parthenon publishing Group; 1994:246.
Morrison JJ, Rennie JM, Milton PJ. Neonatal respiratory morbidity and mode of delivery at term: influence of timing of elective caesarean section. Br J Obstet Gynaecol. 1995;102:101-6.
Wax JR, Herson V, Carignan E, Mather J, Ingardia CJ. Contribution of elective delivery to severe respiratory distress at term. Am J Perinatol. 2002;19(2):81-6.
Narendran V, Randall WR, William LP, Steven BH. Interaction between pulmonary surfactant and vernix: a potential mechanism for induction of amniotic fluid turbidity. J Pediatr Res. 2000;48:120-4.
Klimek R. A new score for postnatal clinical assessment of fetal maturity in newborn infants. Int J Gynecol Obstet. 2000;71:101-5.
Bhatnagar PK. Study of low birth weight neonates. Med J Armed Forces India. 2000;56:293-5.
Klimek R. The use in obstetrics of quantum theory as well as modern technology to decrease the morbidity and mortality of newborns and mothers during iatrogenic induced delivery. Neuroendocrinol Letters. 2001;22:5-8.
Zanardo V, Simbi AK, Franzoi M, Solda G, Salvadori A, Trevisanuto D. neonatal respiratory morbidity risk and mode of delivery at term: influence of timing of elective caesarean delivery. Acta Paediatr. 2004;93:643-7.
Cunningham G, Leveno KJ, Bloom SL, Hauth JC, Gilstrap LC, Wenstorm KD. Diseases and injuries of Fetus and New born. In: Willaims Text book of Obstetrics. 22nd edn. New York: McGraw-Hill Medical Publishing Division; 2005:367.
Park K. Child Survival and Safe Motherhood Programme (CSSM). In: Park’s Text book of Preventive and Social Medicine. 18th edn. Jabalpur: Banarasidas Bhanot Publishers; 2005:344.
Abbas M, Bakr A. Severe respiratory distress in Term infants born electively at high altitude. BMC Pregnancy Childbirth. 2006;6:1-4.
Peter S, Rhiannon W, Ian R. Antenatal betamethasone and incidence of neonatal respiratory distress after elective caesarean section: (ASTECS) pragmatic randomized trial. Obstet Gynecol Survey. 2006;61:157-8.
ACOG committee opinion no. 394. Cesarean delivery on maternal request. Obstet Gynecol. 2007;11096:1501.
ACOG educational bulletin. ACOG Practice Bulletin No. 97: Fetal Lung Maturity. Obstet Gynecol. 2008;112(3):717-26.
Luo G, Norwitz ER. Revisiting amniocentesis for fetal lung maturity after 36 weeks’ gestation. Rev Obstet Gynecol. 2008;1(2):67.
Ram S. Amniotic fluid optical density at spontaneous onset of labor and its correlation with gestational age, birth weight, functional maturity and vernix caseosa of new born. Calicut Med J. 2009;7(4).
Kamath BD, Todd JK, Glazner JE, Lezotte D, Lynch AM. Neonatal outcomes after elective cesarean delivery. Obstet Gynecol. 2009;113(6):1231-8.
Tita ATN, Landon MB, Catherine Y, Lai SY, Leveno, Varner MW, et al. Timing of elective repeat cesarean delivery at term and neonatal outcomes. N Engl J Med. 2009;360:112-20.
Raba G, Baran P. Obstetric outcomes in oxytocin-related and spontaneous deliveries- analysis of 2198 cases. Ginekol Pol. 2009;80(7):508-11.
Al-Zirqi I, Vangen S, Forsén L, Stray-Pedersen B. Effects of onset of labor and mode of delivery on severe postpartum hemorrhage. Am J Obstet Gynecol. 2009;201(3):273.e1-9.
Shankar R Sandya R. Role of echogenic amniotic fluid particles and optical density in prediction of RDS and labor. Internet J Med Update. 2010;5(1):3-11.
Ram SH, Ram S. Role of echogenic amniotic fluid particles and optical density in prediction of respiratory distress syndrome and labor. Internet J Med Update. 2010;5(1).
Samartha ram h, sandhya ram s, amniotic fluid optical density (AFOD) surge coincides with the onset of spontaneous term labor. Paper presented at 55th AICOG-2012.
Hanuman RK. Correlation between amniotic fluid optical density (AFOD) and functional maturity status of the newborn at caesarean delivery in GDM. IOSR J Dent Med Sci. 2014;13(5V):12-6.
Ram SH, Ram SD. Individualized term for each fetus: From surge in amniotic fluid optical density (AFOD). Internet J Gynecol Obstet. 18(1):1-6.
Rao NYL, Isuapalli V, Samyukta Ila S. Amniotic fluid optical density (AFOD) correlates with the lung maturity as well as complete maturity of the fetus- a clinical observational study. IAIM. 2015;2(8):30-7.
Ram HS, Samyuktha IS, Nagasree V. Outcomes of induction of labor with mature and premature amniotic fluid optical density (AFOD): a preliminary case control study. Trop J Obstet Gynaecol. 2019;36(2):206-1.