Association of serum hormone profile and semen quality of infertile males in and around Chennai
Keywords:Semen, Hormones, Infertility, Motility, Sperm count, Morphology
Background: The infertility rate in India has also increased gradually along with population growth. Based on the geographic, the prevalence of male infertility varies. It is noticed that around the world 60–80 million couples with infertility problem every year. The aim of the study was to assess the correlation between the serum hormones and semen quality in infertile males.
Methods: This research study was conducted in 60 infertile males aged from 20–50 years who reported at the Department of Andrology, Kanmani Fertility Centre (Pvt. Ltd.), Chennai, Tamil Nadu, India. The semen and hormone analysis was done in all study participants and its correlation was studied using SPSS (statistical product and service solutions) software.
Results: The results demonstrate that among the study participants, 15.0% of them were normozoospermia, asthenozoospermia (26.6%), asthenoteratozoospermia (21.6%), oligoasthenozoospermia (16.6%) and oligoasthenoteratozoospermia (20.0) respectively. The results of Pearson correlation revealed that TSH, FSH, LH and PRL show a negative correlation but TST level shows a positive correlation with semen parameters.
Conclusions: This study concludes that the serum hormones concentration was observed abnormal in infertile males which show negative correlation with semen parameters of the study participants.
Singh R, Marie GM, Lee W, Ashok A. Thyroid, spermatogenesis, and male infertility. Front Biosci. 2011;E3:843-55.
Jannini EA, Ulisse S, Armiento M. Thyroid hormone and male gonadal function. Endoc Review. 1995;16:443-59.
Matsumoto AM, Karpas AE, Paulsen CA, Bremner WJ. Reinitiation of sperm production in gonadotropin-suppressed normal men by administration of follicle-stimulating hormone. J Clin Invest. 1983;72(3):1005-15.
Tapanainen JS, Aittomaki K, Min J, Vaskivuo T, Huhtaniemi IT. Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility. Nat Genet. 1997;15:205-6.
Veldhuis JD, Iranmanesh A, Urban RJ. Primary gonadal failure in men selectively amplies the mass of follicle stimulating hormone (FSH) secreted per burst and increases the disorderliness of FSH release patterns: reversibility with testosterone replacement. Int J Androl. 1997;20:297-305.
Ramanujam LN, Liao WX, Roy AC. Association of molecular variants of luteinizing hormone with menstrual disorders. Clin Endocrinol. 1999;51:243-246.
Sieber A. Endocrine fertility disorders in the male. Ther Umsch. 1992;49:181-5.
Lwanga SK, Lemeshow S. Sample size determination in health studies, A practical manual. World Health Organization 1991;1-3.
World Health Organization Department of Reproductive Health and Research. WHO laboratory manual for the examination and processing of human semen, Fifth Edition. WHO 2010.
Peter N, Sarah K. In Vitro Fertilization for Male Factor Infertility. J Clinic Endocrinol Metabol. 1997;82(3):709-16.
MacLecd J, Gold RZ. The male factor in fertility. II. Spermatozoon counts in 1000 men of known fertility and in 1000 cases of infertile marriage. J Ural. 1951;66:436-49.
Nicopoullos JDM, Ramsay JWA, Cassar J. From zero to one hundred million in six months: The treatment of azoospermia in congenital adrenal hyperplasia. Archiv Androl. 2003;49(4):257-63.
Stone BA, Alex A, Werlin LB, and Marrs RP. Age thresholds for changes in semen parameters in men. Fertil Steril. 2013;100(4):952-8.
Rodney A, Appell, MD, Paul R Evans. The effect of temperature on sperm motility and viability. Fertilit Steril. 1977;28(12):1329-32.
Boyle CA, Khoury MJ, Katz DF, Annest JL, Kresnow MJ, DeStefano F, Schrader S. The relation of computer-based measures of sperm morphology and motility to male infertility. Epidemiology. 1992;3:239-46.
Auger J, Kunstman J, Czyglik F, Jouannet P. Decline in semen quality among fertile men in Paris during the past 20 years. N Eng J Medic. 1995;332:281-5.
Gustavo FG, and Martha Z. Sperm Motility Should be Assessed in Fresh Sperm and After a Sperm Washing Procedure. Archiv Androl. 1992;28(2):83-9.
Roy S, Banerjee A, Pandey HC, Singh G, Kumari GL. Application of seminal germ cell morphology and semen biochemistry in the diagnosis and management of azoospermic subjects. Asia J Androl. 2001;3(2):55-62.
Rogers BJ, Bentwood BJ, Van Campen H. Sperm morphology assessment as an indicator of human fertilizing capacity. J Androl. 1983;4:119-25.
Gopalakrishnan, Hinduja IN, Anandkuumar TC. Assessment of mitochondrial activity of human spermatozoa. Mol Androl. 1990;3:243-53.
Singh Rajender, Marie Gray Monica, Lee Walter, Ashok Agarwal. Thyroid, spermatogenesis, and male infertility. Front Biosci. 2011;E3(1):843-55.
Krassas GE, Perros P. Thyroid disease and male reproductive function. J Endocrinol Invest. 2003;26:372-80.
Abalovich M, Levalle O, Hermes R, Scaglia H, Aranda C, Zylbersztein C. Hypothalamic-pituitary-testicular axis and seminal parameters in hyperthyroid males. Thyr. 1999;9(9):857-63.
Dipti Sarma, Uma Kaimal, Saikiaand Darvin, Vamadevan Das. Alteration of Sex Hormone and Semen Parameters in Adult Males with Subclinical Hypothyroidism. J Advanc Medic Medic Resea. 2017;23(3):1-7.
Rastrelli G, Corona G, Mannucci E, Maggi M. Factors affecting spermatogenesis upon gonadotropin-replacement therapy: a meta-analytic study. Andrology. 2014;2(6):794-808.
Madhusoodanan V, Patel P, Blachman-Braun R, Ramasamy R. Semen parameter improvements after microsurgical subinguinal varicocele repair are durable for more than 12 months. Can Urol Assoc J. 2020;14(3):E80-3.
Corinne TM, Anatole PC, Jeanne NY. Comparison of Serum Inhibin B and Follicle-Stimulating Hormone (FSH) Level between Normal and Infertile Men in Yaoundé. Int J Reproduct Medic. 2020;2020.
Subhan F, Tahir F, Ahmad, R, Khan ZD. Oligospermia and its relation with hormonal profile. Pak Med Assoc. 1995;45(9):246-7.
Biswas S, Ferguson KM, Stedronska J. Fructose and hormone levels in semen: their correlations with sperm counts and motility. Fertil Steril. 1978;30:200-4.
Eman M Abd Elhafeez, Amal A. Halawa, Mohamed F. Hamed, and Mamdouh M. Abouelmaged. Effects of Cadmium and /or Chromium on reproductive organs and semen profiles of male albino rats. Mans Veterina Medic J. 2019;20(3):14-8.
Bennet A, Bujan L, Plantavid M. Luteinizing hormone pulse frequency and in vitro bioactivity in male idiopathic infertility. Fertil Steril. 1991;55:612-8.
Jeng Hueiwang, Chen Yi-Ling, Kantaria Khyati. Association of cigarette smoking with reproductive hormone levels and semen quality in healthy adult men in Taiwan. J Environment Sci Heal. 2014;49:262-8.
Ahmed Nada, Humeda Ahmed. The relationships between serum prolactin level and semen analysis parameters among patients attended the reproductive health center, Khartoum 2016-2017. Sudan Medic Monit. 2017;12:41-4.
Alıcı B, Citci A, Ozkara H, Akkuş E, Hattat H. The effect of the hyperprolactinemia on semen parameters in male infertility. Cerrahpaşa J Med 1998;29(2):95-8.
Al-Daghistani, Hala I. Evaluation of serum testosterone, progesterone, seminal antisperm antibody, and fructose levels among Jordanian males with a history of infertility. Biochem Res Int. 2010;1:1-8.
Omo-Aghoja LO, Ngwu M, Adeyinka AT. Hormonal parameters and semen microbiological pattern of infertile males: a comparative cross-sectional study in Benin City, South South Nigeria. J West Afr Coll Surg. 2017;7(3):73-93.
Ramesh Babu S, Sadhnani MD, Swarna M, Padmavathi P, Reddy PP. Evaluation of FSH, LH and Testosterone Levels in Different Subgroups of Infertile Males. Ind J Clinic Biochem. 2004;19:45-9.
Ismael ZK, AL-Anbari LA, Mossa HA. Relationship of FSH, LH, DHEA and testosterone levels in serum with sperm function parameters in infertile men. J Pharmaceut Sci Resear. 2017;9(11):2056-61.
Rehm S, White TE, Zahalka, EA, Stanislaus DJ, Boyce RJ, Wier PJ. Effects of food restriction on testis and accessory sex glands in maturing rats. Toxicol Pathol. 2008;36:687-94.
Khan MS, Zaman S, Sajjad M, Shoaib M, Gilani G. Assessment of the level of trace element zinc in seminal plasma of males and evaluation of its role in male infertility. Int J Appl Basic Med Res. 2011;1(2):93-6.