Maternal vitamin D levels in hypertensive disorders of pregnancy

Vatika Tyagi; Mamta Tyagi; Smriti Gupta; Esha Khanuja; Yamini Varma

doi:10.18203/2320-1770.ijrcog20204936

Authors

Vatika Tyagi Department of Obstetrics and Gynaecology, Subharti Medical College, Meerut, Uttar Pradesh, India
Mamta Tyagi Department of Obstetrics and Gynaecology, Subharti Medical College, Meerut, Uttar Pradesh, India
Smriti Gupta Department of Obstetrics and Gynaecology, Subharti Medical College, Meerut, Uttar Pradesh, India
Esha Khanuja Department of Obstetrics and Gynaecology, Subharti Medical College, Meerut, Uttar Pradesh, India
Yamini Varma Department of Obstetrics and Gynaecology, Subharti Medical College, Meerut, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20204936

Keywords:

Vitamin D, Hypertensive disorders, Pregnancy, Preeclampsia

Abstract

Background: Current study was conducted with the objective to evaluate maternal vitamin D levels in patients with hypertensive disorders of pregnancy.

Methods: The present prospective observational study was conducted among 200 pregnant women attending gynaecological OPD of Subharti medical college, Meerut, over a period of two years and satisfying the inclusion criteria were enrolled. On admission, patient demographic profile, complete history was recorded, and comprehensive clinical examination was done. In all the patients, blood samples for routine examination along with LFT, RFT, random blood sugar, serum electrolytes, serum uric acid and serum vitamin D were drawn, and serum levels of these biochemical parameters were determined according to standard laboratory procedures. Subjects were classified into three categories according to serum vitamin D level i.e. >20 ng/ml (mild), 10-20 ng/ml (moderate deficiency), <10 ng/ml (severe deficiency).

Results: Insignificant difference was found between case (hypertensive) and control (normotensive) group when compared in relation to age, education, parity and socioeconomic status. The mean vitamin D level of women with HDP was 5.7+2.99 ng/ml as compared to 17.34+5.79 ng/ml in normotensive women with statistically significant difference as p<0.001. No correlation was found between severity of vitamin D deficiency and maternal complications (p=0.318).

Conclusions: The results of the present study concluded that women with hypertension had significantly lower vitamin D level as compared to normotensive women.

Metrics

Metrics Loading ...

Author Biography

Vatika Tyagi, Department of Obstetrics and Gynaecology, Subharti Medical College, Meerut, Uttar Pradesh, India

subharti medical college

osbtetrics and gynaecology department

junior resident -3

References

Institute of medicine (us) committee to review dietary reference intakes for vitamin D and Calcium. In: Ross AC, Taylor CL, Yaktine AL, Del Valle HB, eds. Dietary Reference Intakes for Calcium and Vitamin D. Washington (DC): National Academies Press (US); 2011.

Ponsonby AL, Lucas RM, Lewis S, and Halliday J. Vitamin D status during pregnancy and aspects of offspring health. Nutrients. 2010;2(3):389-407.

Sharma S, Kumar A, Prasad S, and Sharma S. Current scenario of vitamin d status during pregnancy in North Indian population. J Obstet Gynecol India. 2016;66(2):93-100.

Berhan Y. No hypertensive disorder of pregnancy; no preeclampsia- eclampsia; no gestational hypertension; no hellp syndrome. Vascular disorder of pregnancy speaks for all. Ethiop J Health Sci. 2016;26(2):177-86.

Goel P, Garg G, Kaur J, MehraR, Tandon R, Huria A. Association of vitamin D deficiency during pregnancy with preeclampsia and eclampsia. Int J Reprod Contracept Obstet Gynecol. 2016;5:3046-50.

Sahu M, Tripathy S, Bhuyan P. Association of maternal serum vitamin D level with preeclampsia or eclampsia and its relationship with neonatal outcome and neonatal serum calcium level. Int J Reprod Contracept Obstet Gynecol. 2017;6:5580-6.

Mehta S, Mahala M, Sharma M. Maternal vitamin D levels in hypertensive disorder of pregnancy and healthy pregnant women. IOSR J Dent Med Sci. 2016;15(6):86-8.

Gupta T, Wahi S, Gupta N, Arora S, Gupta S, Bhatia P. Correlation of vitamin D levels in term normotensive and pre-eclamptic patients in labor. J Obstet Gynaecol India. 2016;66(3):154-9.