Seroprevalence rates of Toxoplasma gondii, Rubella, Cytomegalovirus among first trimester pregnant women in Istanbul

Authors

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20205749

Keywords:

Cytomegalovirus, Maternal infection, Prenatal infection, Rubella, Toxoplasma

Abstract

Background: Toxoplasma Gondii, Rubella, and Cytomegalovirus (CMV) are the most common causes of congenital infections worldwide. There is not a consensus on these infectious agents should be screened during pregnancy. The aim of this study is to determine the prevalence of toxoplasma, rubella, and CMV infections in order to know the need for antenatal screening.

Methods: This retrospective cross-sectional study was performed on 1309 ambulatory pregnant patients who applied to the obstetric clinic of a university hospital between October 2016 and April 2018. Documents of patients in the first trimester were reviewed and serologic data of Toxoplasma gondii, CMV, Rubella infections were retrieved from the computer database.

Results: Of 1309 pregnant women, positivity for anti-Toxoplasma IgG antibody was 352(26.9%), while 17(1.3%) of the subjects tested were positive for the anti-Toxoplasma IgM antibody. These positivities of the pregnant women for anti-Rubella IgG and IgM were 1147(87.6%) and (0.1%), respectively. These positivities of the pregnant women for anti-CMV IgG and IgM were 1163(88.8%) and 17(1.3%), respectively.

Conclusions: We detected high rates of immunity against Rubella and CMV but low rates of immunity against Toxoplasma in this retrospective cohort of pregnant women. Due to high rates of seropositivity against Rubella and CMV, routine nationwide screening may not be necessary.

Author Biographies

Aysegul Ozer, Department of Obstetrics and Gynaecology, Istanbul University, Cerrahpasa Medical Faculty Istanbul, Turkey

Obstetrics and Gynecology Department, MD

Mujde Canday, Department of Obstetrics and Gynaecology, Istanbul University, Cerrahpasa Medical Faculty Istanbul, Turkey

Obstetrics and Gynecology Department, MD

Aslihan Yurtkal, Department of Obstetrics and Gynaecology, Istanbul University, Cerrahpasa Medical Faculty Istanbul, Turkey

Obstetrics and Gynecology Department, MD

Ebru Alici Davutoglu, Department of Obstetrics and Gynaecology, Istanbul University, Cerrahpasa Medical Faculty Istanbul, Turkey

Obstetrics and Gynecology Department, MD

Yasam Kemal Akpak, Department of Obstetrics and Gynaecology, Tepecik Training and Research Hospital, Izmir, Turkey

Department of Obstetrics and Gynecology, associate professor, MD

Dogay Nurtac Ozmus, Department of Obstetrics and Gynaecology, Tepecik Training and Research Hospital, Izmir, Turkey

Department of Obstetrics and Gynaecology MD

Alper Ileri, Department of Obstetrics and Gynaecology, Tepecik Training and Research Hospital, Izmir, Turkey

Department of Obstetrics and Gynecology, MD

Adnak Budak, Department of Obstetrics and Gynaecology, Tepecik Training and Research Hospital, Izmir, Turkey

Department of Obstetrics and Gynecology, MD

Riza Madazli, Department of Obstetrics and Gynaecology, Istanbul University, Cerrahpasa Medical Faculty Istanbul, Turkey

Obstetrics and Gynecology Department, professor, MD

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Published

2020-12-26

Issue

Vol. 10 No. 1 (2021): January 2021

Section

Original Research Articles