Study of the obstetrics and perinatal outcome of in vitro fertilization pregnancies at tertiary care centre
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20212152Keywords:
In vitro fertilization, Intra uterine foetal death, Assisted reproductive technologies, Preterm, Low birth weightAbstract
Background: Assisted reproductive techniques (ART) has been a boon to the unfortunate. However, the outcomes aren’t the same to all. The study has observed the outcomes in IVF conceived patients. The pregnant women were followed-up throughout their antenatal and post-natal (7 days) period and an appropriate meta-analysis was made.
Methods: This is an Observational Prospective study. It was conducted at an IVF center of tertiary hospital. With valid written informed consents 96 patients were recruited and observed for18 months. Data collected by Universal sampling method, analyzed and interpreted.
Results: A total 65.6% belonged above 30 years, 67.7% were primigravida and 7.3% had history of previous ectopic pregnancy. In 23.75% multifetal pregnancy was significant and 20.63% had OS tightening done. Most common reason for opting IVF was multiple failed IUI (71.6%). More than 40% were delivered by caesarean section. 91.1% of babies cried immediately after birth and 50.4% babies required NICU admission.13.4% babies had neonatal death and 3.1% were IUFD. 58.30% pregnancies were singleton. Mean birth weight was 1.87 Kg and 72.6% children were born low birth weight. Statistical significance (p<0.001) was found in between no. of foetuses delivered and preterm delivery. 56.3% birth were preterm birth. PIH and GDM complication is most common in multiple gestations observed in 10.7% of pregnancies.
Conclusions: Assisted Reproductive technologies has helped the infertile couples. Outcomes could be unfruitful in few, while others may have a complicated antenatal period. Preterm deliveries are more common in multiple gestation thus complementing the lower birth weights. Comorbidities significantly affected obstetric outcome.
References
Ginsburg ES RC. Assisted reproduction. 7th ed. Elsevier Saunders; 2014.
Aiken CEM, Brockelsby JC. Fetal and Maternal Consequences Of Pregnancies Conceived Using Art. Fetal Matern Med Rev. 2014;25:281-94.
Källén B, Finnström O, Olausson, Nygren PO. In vitro fertilization ( IVF ) in Sweden : infant outcome after different IVF fertilization methods. 2005;84.
Shi W, Xue X, Zhang S, Zhao W, Liu S, Ph D, et al. Perinatal and neonatal outcomes of 494 babies delivered from 972 vitri fi ed embryo transfers. Fertil Steril. 2012;97:1338-42.
Nouri K, Ott J, Stoegbauer L, Pietrowski D, Frantal S, Walch K. Obstetric and perinatal outcomes in IVF versus ICSI-conceived pregnancies at a tertiary care center - a pilot study. Reprod Biol Endocrinol 2013;11:1.
Maman E, Lunenfeld E, Levy A, Ph D, Vardi H, Sc M. Obstetric outcome of singleton pregnancies conceived by in vitro fertilization and ovulation induction compared with those conceived spontaneously. 1998;70:2-7.
Mustafa, Kamarul B, Keane KN, Walz NL, Mitrovic KI, Hinchliffe PM, Yovich JL. Live birth rates are satisfactory following multiple IVF treatment cycles in poor prognosis patients. Phytochem Lett. 2016.
Reubinoff BE. Is the obstetric outcome of in vitro fertilized singleton gestations different from natural ones ? A controlled study. 1997;02:82.
Akbari P. Fetal and Maternal Effects of Pregnancy after Using IVF / ICSI in Women Comprehensive Hospital in Tehran in 5 Years. Sch J Appl Med Sci. 2016;4:3577-80.
Perri T, Chen R, Yoeli R, Merlob P, Orvieto R, Shalev Y, et al. Are singleton assisted reproductive technology pregnancies at risk of prematurity? J Assist Reprod Genet. 2001;18:245-9. Chen Y, Zheng X, Yan J, Qiao J, Liu P. Neonatal outcomes after the transfer of vitrified blastocysts : closed versus open vitrification system 2013:1-5.
Smithers PR, Halliday J, Hale L, MacKenzie Talbot J, Breheny S, Healy D. High frequency of cesarean section, antepartum hemorrhage, placenta previa, and preterm delivery in in-vitro fertilization twin pregnancies. Fertil Steril. 2003;80:666-8.
Moise J, Laor A, Armon Y, Gur I, Gale R. The outcome of twin pregnancies after IVF. 1998;13:1702-5.
Fujii M, Matsuoka R, Ph D, Bergel E, Ph D. Perinatal risk in singleton pregnancies after in vitro fertilization. Fertil Steril. 2010;94:2113-7.
Tallo CP, Vohr B, Oh W, Rubin LP, Seifer DB, Haning R V. Maternal and neonatal morbidity associated with in vitro fertilization. J Pediatr. 1995;127:794-800.
Westergaard HB, Johansen AMT. Danish National In-Vitro Fertilization Registry 1994 and 1995 : a controlled study of births , malformations and cytogenetic findings. 1999;14:1896-902.
Fujii M, Matsuoka R, Ph D, Bergel E, Ph D. Perinatal risk in singleton pregnancies after in vitro fertilization. Fertil Steril. 2010;94:2113-7.
Tallo CP, Vohr B, Oh W, Rubin LP, Seifer DB, Haning R V. Maternal and neonatal morbidity associated with in vitro fertilization. J Pediatr. 1995;127:794-800.
Fujii M, Matsuoka R, Ph D, Bergel E, Ph D. Perinatal risk in singleton pregnancies after in vitro fertilization. Fertil Steril. 2010;94:2113-7.
D MASM, D JPTM, Ph D, N CKBS, D SJMM. Create account Sign in Outcome of twin , triplet , and quadruplet in vitro fertilization pregnancies : the Norfolk experience * 2019:1–3. [20] Poikkeus P, Gissler M, Tiitinen A. Obstetric and neonatal outcome after single embryo transfer 2007;22:1073–9.
Tallo CP, Vohr B, Oh W, Rubin LP, Seifer DB, Haning R V. Maternal and neonatal morbidity associated with in vitro fertilization. J Pediatr. 1995;127:794-800.
Källén B, Finnström O, Olausson, Nygren KG. In vitro fertilization ( IVF ) in Sweden : infant outcome after different IVF fertilization methods 2005;84. [23]Akbari P et al. Fetal and Maternal Effects of Pregnancy after Using IVF / ICSI in Women Comprehensive Hospital in Tehran in 5 Years. Sch J Appl Med Sci. 2016;4:3577-80.
Rahu K, Allvee K, Karro H, Rahu M. Singleton pregnancies after in vitro fertilization in Estonia: A register-based study of complications and adverse outcomes in relation to the maternal socio-demographic background. BMC Pregnancy Childbirth. 2019;19:1-9.
Stewart LM, Holman CDAJ, Finn JC, Preen DB, Hart R. In vitro fertilization is associated with an increased risk of borderline ovarian tumours. Gynecol Oncol. 2013;129:372-6.
Tough SC, Greene CA, Svenson LW, Belik J. Effects of in vitro fertilization on low birth weight, preterm delivery, and multiple birth. J Pediatr. 2000;136:618-22.
Gissler M, Silverio MM, Hemminki E. In-vitro fertilization pregnancies and perinatal health in Sign in Oxford Academic account Sign in via your Institution. 2019:1-7.
Helmerhorst FM, Perquin DAM, Donker D, Keirse MJNC. Papers Perinatal outcome of singletons and twins after assisted conception : a systematic review of controlled studies. 2004;1-5.
