Perinatal outcome in abnormal placental villus proliferation and mesenchymal dysplasia
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20210333Keywords:
Partial hydatidiform mole, Placental mesenchymal dysplasia, PlacentomegalyAbstract
Placental mesenchymal dysplasia (PMD) is a rare vascular anomaly which is characterized by mesenchymal stem villous hyperplasia and placentomegaly. Since the modality of treatment changes it is necessary to distinguish PMD from molar pregnancy, placenta mosaicism, chorioangioma, twin pregnancy with co-existent molar pregnancy. On reviewing cases of abnormal placental villus proliferation having features of placental mesenchymal hyperplasia placentomegaly and cystic appearance of placenta in database of our hospital from 2015-2019, we reported 4 cases of abnormal placental villous proliferation. And performed systematic review of existing literature. Provisional diagnosis of PMD was made as USG and placental morphology showed 30-60% of the placenta with cystic vesicles, placentomegaly with a normal growing fetus. PMD an uncommon vascular anomaly which resembles molar pregnancy but prognosis is different. The fetus was normal in majority of the cases. This clinical entity should be kept in mind to avoid unnecessary termination of pregnancy.
References
Parveen Z, Tongson-Ignacio JE, Fraser CR, Killeen JL, Thompson KS. Placental Mesenchymal Dysplasia. Arch Pathol Lab Med. 2007;131(1):131-7.
Nayeri UA, West AB, Nardini GJA, Copel AK, Sfakianaki AK. Systematic review of sonographic findings of placental mesenchymal dysplasia and subsequent pregnancy outcome. Ultrasound Obstet Gynecol. 2013;41(4):366-74.
Pawoo N, Heller DS. Placental Mesenchymal Dysplasia. Arch Pathol Lab Med. 2014;138(9):1247-9.
H'mida D, Gribaa M, Yacoubi T, Chaieb A, Adala L, Elghezal H et al. Placental mesenchymal dysplasia with Beck-Wiedemann syndrome fetus in the context of biparental and androgenic cell lines. Placenta. 2008;29(5):454-60.
Schuetzle M, Uphoff TS, Hatten BA, Dawson DB. Utility of microsatellite analysis in evaluation of pregnancies with placental mesenchymal dysplasia. Prenat Diagn. 2007;27(13):1238-44.
Armes J, McGown I, Williams M, Broomfield A, Gough K, Lehane F, Lourie R. The placenta in Beckwith-Wiedemann syndromegenotype-phenotype associations, excessive extravillous trophoblast and placental mesenchymal dysplasia. Roy Coll Pathol Aust. 2012;44(6):1-9.
Schuetzle M, Uphoff TS, Hatten BA, Dawson DB. Utility of microsatellite analysis in evaluation of pregnancies with placental mesenchymal dysplasia. Prenat Diagn. 2007;27(13):1238-44.
Aviram R, Kidron D, Silverstein S, Lerer I, Abeliovich D, Tepper R et al. Placental mesenchymal dysplasias associated with transient neonatal diabetes mellitus and paternal UPD6. Placenta. 2008;29(7):646-9.
Mungen E, Dundar O, Muhcu M, Haholu A, Tunca Y. Placental mesenchymal dysplasia associated trisomy 13: sonographic findings. J Clin Ultrasound. 2008;36(7):454-6.
Robinson WP, Slee J, Smith N, Watson SK, Lam WL, McFadden DE. Placental mesenchymal dysplasia associated with fetal overgrowth and mosaic deletion of the maternal copy of 11p15.5. Am J Med Genet A. 2007;143A(15):1752-9.
Parveen Z, Tongson-Ignacio JE, Fraser CR, Killeen JL, Thompson KS. Placental Mesenchymal Dysplasia. Arch Pathol Lab Med. 2007;131(1):131-7.