DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20210698

Breast cancer in adolescent and young adult Ivory coast women: epidemiological and clinical features and molecular subdivision

Edele Kacou Aka, Apollinaire Horo, Abdoul Koffi, Mohamed Fanny, Coulibaly Didi-Kouko, Guy Nda, Alain Abouna, Mamourou Kone

Abstract


Background: To describe the anatomy and clinical features and then determine the histological and molecular profile of Ivorian women under 40 years.

Methods: This is a retrospective multi-centre study descriptive and analytic performed over a period of 20 months. It involved 76 women on 355 selected in the Ivoirian cancer registry. An additional immunohistochemical analysis to assess hormone receptors and HER overexpression in a single unit.

Results: Adolescents and young adults represented 20.3% of women with breast cancer. The average age of women was 35 years. (∂=3.4 years, 95% CI=[2.6415 to 4.1785]). 15.8% of patients had a good socioeconomic level with a stable job, well paid and 28.9% had a university degree. The discovery circumstances were a breast nodule (53%) followed by locoregional complications (21%) and breast self-examination (20%). The consultation delay was less than three months in 34.2% of cases. 78% of cancers were diagnosed in stage II and III. The most common histological subtypes were respectively RP (+) / Her (-) (41%) followed by triple negative (30%).

Conclusions: This study showed that 20,3% of women under 40 years. The most tumors were classified as stage II and III of tumors at diagnosis. the most common histologic subtypes are the Luminal A (41%) and triple-negative (30%). This disease is more aggressive with a poor prognosis in this age group.


Keywords


Breast cancer, Adolescents and young adults, Molecular profile, Côte d’Ivoire

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References


Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C et al. GLOBOCAN 2012 V1.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No.11 Lyon, France: International Agency for Research on Cancer. 2013.

Parkin DM, Bray F, Ferlay J, P Pisani. CA Cancer J Clin. 2005;55(2):74-108.

Echimane AK, Ahnoux AA, Adoubi I, Hien S. Cancer incidence in Abidjan, Ivory Coast: first results from the cancer registry 1995-1997. Cancer in Word. 2000;86,3:653-63.

Bleyer A, R Barr, Hayes-Lattin B, Thomas D, C Ellis, Anderson B. The distinctive biology of cancer in adolescents and young adults. Nat Rev Cancer. 2008;8(4):288-98.

Gabriel CA, Domchek SM. Breast cancer in young women. Breast Cancer Res. 2010;12(5):212.

Gnerlich JL, Deshpande AD, Jeffe DB, Doux A, Blanc N, le juge Margenthaler. Elevated breast cancer mortality in women younger than age 40 years compared with older women is attributed to poorer survival in early-stage disease. J Am Coll Surg. 2009;208(3):341-7.

Madani Ly, Martine A., Fabrice A. Le cancer du sein chez la femme de l’Afrique subsaharienne : état actuel des connaissances. Bull cancer. 2011;98(7):797-806.

Perou CM, Sørlie T, Eisen MB. Molecular portraits of human breast tumours. Nature 2000 ;406:747-52.

Sørlie T, Perou CM, Tibshirani R. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 2001 ;98:10869-874.

Carey LA, Perou CM, Livasy CA. Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA. 2006 ;295:2492-502.

Hammond. ASCO/CAP Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast cancer. J Clin Oncol. 2010

Penault-Llorca F. Groupe d’Evaluation des Facteurs Pronostiques par Immunohistochimie dans les Cancers du Sein (GEFPICS). Ann Pathol. 2010;30:357‐73.

Fredholm H, Eaker S, Frisell J, Holmberg L, Fredriksson I, Lindman H. Breast Cancer in Young Women: Poor Survival Despite Intensive Treatment. PLoS One. 2009;4(11):A38-46.

Bharat A, Aft RL, Gao F, Margenthaler JA. Patient and Tumor Characteristics Associated With Increased Mortality in Young Women (< = 40 Years) With Breast Cancer. Journal of Surgical Oncology. 2009;100(3):248-51.

El Saghir NS. Effects of young age at presentation on survival in breast cancer. BMC Cancer. 2006;6:194.

Sidoni A, Cavaliere A, Bellezza G, Scheibel M, Bucciarelli E. Breast cancer in young women: clinicopthological features and biological specificity. 2003;12(4):247-50.

McAree B. Breast cancer in women under 40 years of age: a series of 57 cases from Northern Ireland. Breast. 2010;19(2):97-104.

Kurian AW, Fish K, Shema SJ, Clarke CJ. Lifetime risks of specific breast cancer subtypes among women in four racial/ethnic groups Breast Cancer Res. 2010;12(6).

Vona-Davis L, Rose DP. The influence of socioeconomic disparities on breast cancer tumor biology and prognosis: a review. J Womens Health (Larchmt). 2009;18(6):883-93.

Yang XR, Chang-Claude J, Goode EL. Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies J Natl Cancer Inst. 2011;103(3):250-63.

Chagpar AB, Polk HC, Jr, McMasters KM. Racial trends in mammography rates: a population-based study Surgery. 2008;144(3):467-72.

Clarke CA, Keegan THM, Yang J. Age-Specific Incidence of Breast Cancer Subtypes: Understanding the Black-White Crossover J Natl Cancer Inst. 2012;104(14):1094-101.

Kurian AW. BRCA1 and BRCA2 mutations across race and ethnicity: distribution and clinical implications. Curr Opin Obstet Gynecol. 2010;22:72-78.

Thangjam S, Laishram RS, Debnath K. Breast carcinoma in young females below the age of 40 years: A histopathological perspective. South Asian J Cancer. 2014;3(2):97-100.

Boyd NF, Martin LJ, Sun L. Body size, mammographic density, and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2006;15:2086-092.

M. Boisserie-Lacroixa, B. Bullier a, G. Hurtevent-Labrota. Corrélations imagerie-facteurs pronostiques — classification moléculaire des cancers du sein. Journal de Radiologie Diagnostique et Interventionnelle. 2014;95:230-36.

Feldman AL, Welch JP. Long-term outcome in women less than 30 years of age with breast cancer. J Surg Oncol. 1998;68:193-8.

Livi L, Meattini I, Saieva C, Borghesi S, Scotti V, Petrucci A, et al. The impact of young age on breast cancer outcome. Eur J Surg Oncol. 2010;36:639-45.

Elkhuizen PH, van de Vijver MJ, Hermans J. Local recurrence after breast-conserving therapy for invasive breast cancer: high incidence in young patients and association with poor survival. Int J Radiat Oncol Biol Phys. 1998;40:859-67.

Kwong A, Cheung P, Chan S, Lau S. Breast cancer in Chinese women younger than age 40: Are they different from their older counterparts? World J Surg Onc. 2008;32:2554-61.

Cristofanilli M. Invasive lobular carcinoma classic type: Response to primary chemotherapy and survival outcomes. J Clin Oncol. 2005;23:41-8.

Sotiriou C, Neo SY, McShane LM. Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc Natl Acad Sci USA. 2003;100:10393-0398.

Parise CA, Bauer KR, Caggiano V. Variation in breast cancer subtypes with age and race/ethnicity Crit Rev Oncol Hemat. 2010;76(1):44-52.

Assi HA. Epidemiology and prognosis of breast cancer in young women. J Thorac Dis. 2013;5:S2-8.

Rao C, Shetty J, Kishan Prasad HL. Morphological profile and receptor status in breast carcinoma: An institutional study. J Can Res Ther. 2013;9:44-9.