Role of autologous bone marrow derived stem cells and platelet rich plasma for endometrial regeneration and repair and ovarian rejuvenation

Authors

  • Manjula Anagani 1Department of Obstetrics and Gynecology, Medicover Woman and Child Hospital, Hyderabad, Telangana, India
  • Prabha Agrawal 2Department of Internal Medicine, Medicover Woman and Child Hospital, Hyderabad, Telangana, India
  • Bollavaram Vikas Reddy 3Department of Orthopedics, Medicover Woman and Child Hospital, Hyderabad, Telangana, India
  • Prabhu Chandra Mishra 4Head, Stem Max Research and Therapeutics Pvt Ltd, New Delhi, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20210311

Keywords:

Bone marrow-derived stem cell, Platelet rich plasma, Premature ovarian failure, Thin endometrium

Abstract

Background: Stem cells are undifferentiated cells with a potential for self- renewal and differentiation into multiple mature cell types. PRP is blood plasma that has been enriched with platelets and multiple growth factors that can stimulate cellular processes and activate multi-potent stem cells to generate new, younger tissue and new blood vessels relevant to ovarian rejuvenation and endometrial regeneration.

Methods: This study was to evaluate the effectiveness of ABMDSC and PRP application in patients with thin endometrium refractory to treatment, premature ovarian failure, infertility and menopause. 37 symptomatic women between age group 18 years to 56 years were selected for ABMDSC and PRP instillation in endometrium and/ or ovaries. PRP was instilled in endometrium in 8 patients, in ovaries in 5 patients and in both endometrium and ovaries in 24 patients.

Results: There was significant improvement in endometrial thickness, along with improved blood flow to both endometrium and ovaries. FSH levels decreased and ovarian volume increased. There were three confirmed pregnancies with one delivery.  Menopausal symptoms decreased in 2 patients and spontaneous resumption of menses was seen in 1 patient of POF.

Conclusions: Stem cell therapy serves as a game changer with their unique properties, offering solutions for scores of women suffering from POF, poor oocyte quality, endometrial degeneration/ damage or menopausal symptoms.

 

Author Biographies

Manjula Anagani, 1Department of Obstetrics and Gynecology, Medicover Woman and Child Hospital, Hyderabad, Telangana, India

Director and HOD

Prabha Agrawal, 2Department of Internal Medicine, Medicover Woman and Child Hospital, Hyderabad, Telangana, India

HOD Academics

Bollavaram Vikas Reddy, 3Department of Orthopedics, Medicover Woman and Child Hospital, Hyderabad, Telangana, India

MS, Consultant Orthopaedic surgeon

Prabhu Chandra Mishra, 4Head, Stem Max Research and Therapeutics Pvt Ltd, New Delhi, India

Head

StemMax Research and Therapeutics Pvt Ltd.

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Published

2021-01-28

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Original Research Articles