Role of leptin in preeclampsia
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20210351Keywords:
Leptin, PreeclampsiaAbstract
Preeclampsia is one of the common complications of pregnancy and associated with elevated leptin concentrations. In this review the potential sources of leptin are explored and the factors that contribute to maternal increased concentrations of leptin include obesity, insulin resistance and hypoxia. Further research is warranted to understand the role of leptin in pathogenesis of preeclampsia.
References
Jeyabalan A. Epidemiology of preeclampsia: impact of obesity. Nutr Rev. 2013;71:S18-S25.
Sharma A, Satyam A, Sharma JB. Leptin, IL-10 and Inflammatory Markers (TNF-α, IL-6 and IL-8) in Pre-Eclamptic, Normotensive Pregnant and Healthy Non-Pregnant Women. American Journal of Reproductive Immunology. 2007;58:21-30.
Ramos-Lobo AM, Donato J Jr. The role of leptin in health and disease. Temperature (Austin). 2017;4(3):258-291.
Napso T, Yong HEJ, Lopez-Tello J, Sferruzzi-Perri AN. The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation. Front Physiol. 2018;9:1091.
Pérez-Pérez A, Toro A, Vilariño-García T, Maymó J, Guadix P, Dueñas JL et al. Leptin action in normal and pathological pregnancies. J Cell Mol Med. 2018;22(2):716-727.
Kelesidis T, Kelesidis I, Chou S, Mantzoros CS. Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med. 2010;152(2):93-100.
Ajala OM, Ogunro PS, Elusanmi GF, Ogunyemi OE, Bolarinde AA. Changes in serum leptin during phases of menstrual cycle of fertile women: relationship to age groups and fertility. Int J Endocrinol Metab. 2013;11(1):27-33.
Sattar N, Greer IA, Pirwani I, Gibson J, Wallace AM. Leptin levels in pregnancy: marker for fat accumulation and mobilization? Acta Obstet Gynecol Scand. 1998;77(3):278-83.
Laird SM, Quinton ND, Anstie B, Li TC, Blakemore AI. Leptin and leptin-binding activity in women with recurrent miscarriage: correlation with pregnancy outcome. Hum Reprod. 2001;16(9):2008-13.
Challier J, Galtier M, Bintein T, Cortez A, Lepercq J, Hauguel-de Mouzon S. Placental leptin receptor isoforms in normal and pathological pregnancies. Placenta. 2003;24(1):92-9.
Lopez-Jaramillo P, Barajas J, Rueda-Quijano SM, Lopez-Lopez C, Felix C. Obesity and Preeclampsia: Common Pathophysiological Mechanisms. Front Physiol. 2018;9:1838.
Thagaard IN, Hedley PL, Holm JC, Lange T, Larsen T, Krebs L and Christiansen M: Leptin and adiponectin as markers for preeclampsia in obese pregnant women, a cohort study. Pregnancy Hypertens. 2019;15:78-83.
Xiao WQ, He JR, Shen SY, Lu JH, Kuang YS, Wei XL et al. Maternal circulating leptin profile during pregnancy and gestational diabetes mellitus. Diabetes Research and Clinical Practice. 2020;161:108041.
Taylor BD, Ness RB, Olsen J, Hougaard DM, Skogstrand K, Roberts JM et al. Serum leptin measured in early pregnancy is higher in women with preeclampsia compared with normotensive pregnant women. Hypertension. 2015;65(3):594-9.
Mise H, Sagawa N, Matsumoto T, Yura S, Nanno H, Itoh H et al. Augmented placental production of leptin in preeclampsia: possible involvement of placental hypoxia. J Clin Endocrinol Metab. 1998;83(9):3225-9.
Dotsch J, Nusken KD, Knerr I, Kirschbaum M, Repp R, Rascher W. Leptin and neuropeptide Y gene expression in human placenta: ontogeny and evidence for similarities to hypothalamic regulation. The Journal of Clinical Endocrinology & Metabolism. 1999;84(8):2755-8.
Giordano R, Cacciatore A, Romano M, La Rosa B, Fonti I, Vigna R. Uterine artery Doppler flow studies in obstetric practice. J Prenat Med. 2010;4(4):59-62.
Salimi S, Farajian-Mashhadi F, Naghavi A, Mokhtari M, Shahrakipour M, Saravani M et al. Different profile of serum leptin between early onset and late onset preeclampsia. Disease markers. 2014;2014.
Laivuori H, Gallaher MJ, Collura L, Crombleholme WR, Markovic N, Rajakumar A et al. Relationships between maternal plasma leptin, placental leptin mrna and protein in normal pregnancy, pre-eclampsia and intrauterine growth restriction without pre-eclampsia. Mol Hum Reprod. 2006;12:551-556.
Bakacak M, Kılınç M, Serin S, Ercan Ö, Köstü B, Avcı F, et al. Changes in Copper, Zinc, and Malondialdehyde Levels and Superoxide Dismutase Activities in Pre-Eclamptic Pregnancies. Medical science monitor: international medical journal of experimental and clinical research. 2015;21:2414.
Redman CW, Sargent IL. Placental stress and pre-eclampsia: a revised view. Placenta. 2009;30(SupplA):S38-42.
Black RE. Micronutrients in pregnancy. Br J Nutr. 2001;85:93-197.
Rathore S, Gupta A, Batra HS, Rathore R. Comparative study of trace elements and serum ceruloplasmin level in normal and pre-eclamptic pregnancies with their cord blood. Biomed Res. 2011;22:207-10.
