Incidence and risk factors associated with ectopic pregnancy: a prospective study

Harish K. M., Shwetha N., Nalini N.


Background: Increased incidence of ectopic pregnancy and its impact on women’s fertility in recent years need significant attention.

Methods: A two years prospective study from January 2018 to December 2019 conducted to determine incidence, association of risk factors with ectopic pregnancy and find the most common risk factor of ectopic pregnancy in department of obstetrics and Gynaecology, a tertiary care Hospital in Pune.

Results: During the study period 100 patients were diagnosed to have ectopic pregnancy. Incidence was 5.29 per 1000 births. Majority were in the age group of 20-24 years (42%), multiparous (59%) and belong to low socioeconomic state (62%). In majority of the patients (22%) no risk factors was found. Among the patients who had risk factors, the main risk factors for ectopic pregnancy were history of history of pelvic inflammatory disease (20%), previous tubal/abdominal surgery (12%), history of Infertility (10%), previous termination of pregnancy (10%), contraception with mirena IUS or IUCD in situ (8%) and a history of prior ectopic pregnancy (4%).

Conclusions: In majority (78%) of patients risk factors for ectopic pregnancy was present and pelvic inflammatory disease was found to be a major risk factor for ectopic pregnancy.


Ectopic, PID, Fallopian tube

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Te Linde’s Operative Gynaecology, 8th ed, Lippincott — Raven, Philadelphia. 1997;501-27.

Hankins GD, Clark SL, Cunningham FG, Gilstrap LC. Ectopic pregnancy. In: Operative obstetrics. Norwalk, Conn.: Appleton & Lange. 1995;437-56.

Ectopic pregnancy—United States, 1990–1992. MMWR Morb Mortal Wkly Rep. 1995;44:46-8.

PISARSKA, MARGARETA D, CARSON, SANDRA A. Incidence and Risk Factors for Ectopic Pregnancy, Clinical Obstetrics and Gynecology. 1999;42(1):2-8.

Malak M, Tawfeeq T, Holzer H, Tulandi T. Risk factors for ectopic pregnancy after in vitro fertilization treatment. J Obstet Gynaecol Can. 2011;33(6):617-9.

Lakshmi S, Babita K, Bala HP, Nidhi C. A Retrospective Analysis on Ectopic Pregnancy: A One Year Study. Sch J App Med Sci. 2017;5(8E):3318-23.

Madan A, Nitin KH, Kaur A, Neki NS. Ectopic Pregnancy: A life threatening emergency. Int J Curr Res Med Sci. 2017;3(7):144-151.

Mishra S, Chaudhary V, Kaul R, Tabassum B. Analysis of 62 Cases of Ectopic Pregnancies in a Rural Medical College Set Up at Nalgonda Telangana, India. Int J Sci Stud. 2015;3(6):103-06.

Shetty SK, Anil SK. Innovative Journal of Medical and Health Science. 2014;4(1):305-09.

Archana MS, Soumini G. Study Of Ectopics In Emergency Surgical Admissions. Global Journal For Research Analysis. 2017;9(6):2277-8160.

Tahmina S, Daniel M, Solomon P. Clinical Analysis of Ectopic Pregnancies in a Tertiary Care Centre in Southern India: A Six-Year Retrospective Study. Journal of Clinical and Diagnostic Research. 2016;10(10):13-16.

Panelli DM, Phillips CH, Brady PC. Incidence, diagnosis and management of tubal and nontubal ectopic pregnancies: a review. Fertil Res Pract. 2015;1:15.

LaxmiKarki L, Pradhan B, Duwa S. Annual Analysis of Ectopic Pregnancy in Tertiary Care Hospital. PMJN. 2011;11:5-8.

Karaer A, Avsar FA, Batioglu S. Risk factors for ectopic pregnancy: a case-control study. Aust N Z J ObstetGynaecol. 2006;46:521-27.

Turner C, Horner P. British Fertility Society Impact of Chlamydia trachomatis in the reproductive setting: British Fertility Society Guidelines for practice. Hum Fertil (Camb). 2010;13:115-25.

Singh S, Mahendra G, Vijayalakshmi S, Pukale RS. Clinical study of ectopic pregnancy in a rural setup: A two year survey. Natl J Med Res. 2014;4(1):37-39.

Mufti S, Rather S, Mufti S, Rangrez RA, Wasiqa K. Ectopic pregnancy: An analysis of 114 cases. JK-Pract. 2012;17(4):20-23.

Cates W, Rolfs RT, Aral SO. Sexually transmitted diseases, pelvic inflammatory disease, and infertility: an epidemiologic update. Epidemiol Rev. 1990;12:199-220.

Vyas PS, Vaidya P. Epidemiology, diagnosis and management of ectopic pregnancy – An analysis of 196 cases. BHJ Orig Res Artic. Available from: html: file://e: epidemiology, diagnosis and management of ectopic pregnancy. Last accessed on 22 August, 2015

Patel UM, Gandhi MR, Jani PS, Kakani CR, Thakor N. Clinical profile and management of ectopic pregnancy in patients with ectopic pregnancy at GMERS medical college and hospital Dharpur-Patan, North Gujarat region, India. Int J Res Med Sci. 2015;3:841-5.

Clayton HB, Schieve LA, Peterson HB, Jamieson DJ, Reynolds MA, Wright VC. Ectopic pregnancy risk with assisted reproductive technology procedures. Obstet Gynecol. 2006;107:595-604.

Virk J, Zhang J, Olsen J. Medical abortion and the risk of subsequent adverse pregnancy outcomes. N Eng J Med. 2007;357:648-53.

Gandotra N, Zargar S. Risk factors associated with ectopic pregnancy in our sociodemographic setup. Int J Reprod Contracept Obstet Gynecol. 2020;9:4150-4.

Jain S H, Ghike S, Gawande MS, Joshi SA, Kawthalkar AS, Somalwar SA. LNG Emergency contraceptive pills: Risk factors for pregnancy. J South Asian Feder Obst Gynae. 2013;5(2):87-8.

European Society of Human Reproduction and Embryology (ESHRE). Women whose first pregnancy was ectopic have fewer children and high risk of another ectopic pregnancy. ScienceDaily. 2012. Available at: releases/2012/10/121018100154.htm. Accessed on 17 November, 2020.