Value of endometrial aspiration cytology in assessing the endometrial status in symptomatic peri and postmenopausal women and its histological correlation with fractional curettage


  • M. Vennila Department of Obstetrics & Gynecology, Tirunelveli Medical College and Hospital, Tirunelveli, Tamil Nadu, India
  • Thangalakshmi . Department of Obstetrics & Gynecology, Tirunelveli Medical College and Hospital, Tirunelveli, Tamil Nadu, India



Dysfunctional uterine bleeding, Dilatation and curettage, Atrophic endometrium, Polymenorrhoea


Background: Abnormal uterine bleeding (AUB) is associated with a wide variety of endometrium. Endometrial interpretation is valuable not only to find the etiology of AUB but also to rule out any organic cause for abnormal uterine bleeding. Fractional curettage is one of the most reliable and commonly performed diagnostic techniques used in the investigation of AUB. To evaluate the efficacy of endometrial aspiration cytology in the diagnosis of abnormal uterine bleeding by correlating it with histopathology.

Methods: This comparative study to be conducted in100 patients attending antenatal clinic at Department of OBG, Tirunelveli Government medical college hospital from January 2018– July 2019. (17) months. Specific investigations like abdominal ultrasonography, thyroid profile, platelet count, bleeding time, clotting time, prothrombin time, etc were done whenever required. Informed consent was taken from all the study patients. Prior to Fractional curettage, endometrial aspiration was done using plastic disposable pipelines of 3 mm diameter.

Results: The sensitivity of the cytology in detecting carcinoma of the endometrium was 83.3%. The specificity of cytology is 100%. Hence the test is highly specific in diagnosis. The positive predictive value is also 100% and the negative predictive value is 99%.

Conclusions: It can also detect a few of the endometrial pathologies like endometrial hyperplasia, atrophy, and atypia. It is office Procedure. reduction in associated surgical risks, expense, post-operative pain, and need for operative anesthesia as seen in fractional curettage.

Author Biography

M. Vennila, Department of Obstetrics & Gynecology, Tirunelveli Medical College and Hospital, Tirunelveli, Tamil Nadu, India



Affandi MZ, Joseph R, Minish SR, Doctor V. Single endometrial aspiration for detection of ovulation. Int J Gynecol Obst. 1983;21:395- 401.

Anderson MG, Eaton CJ, Galinkim LJ, Newton CW, Haines JP, Miller NF. The cytologic diagnosis of endometrial adenocarcinoma. Am J Obstet Gynecol. 1976;125:376-83.

Ayre JE. Rotating endometrial brush; a new technique for diagnosis of fundal carcinoma.

Barbaro CA, Fortune DW, Bodey AS. Uterine lavage in the diagnosis of endometrial malignancy and its precursors. Acta Cytol. 1982;26:135-40.

Byrne AJ. Endocyte endometrial smears in the cyst diagnosis of endometrial carcinoma. Acta Cytol. 1990;34:373-81.

Cardoso PM, D’Silva EA. Dysfunctional uterine bleeding- A review. J Obs Gynae. 2004;9(1):47-50.

Cary WH. A method of obtaining endometrial smears for the study of their cellular contents. Am J Obst Gynec. 1943; 46:422-3.

Chakravarthy A. Diagnostic efficacy of endometrial cytology. Obstet Gynecol. 1986;134:147-51.

Crow J, Gordon H, Hudson E. An assessment of the Mi- Mark endometrial sampling technique. J Clin Pathol. 1980;33(1):72-80.

Davey DA. Dysfunctional uterine bleeding. In: Keith ED, editor. Dewhurst’s Textbook of Obstetrics and Gynaecology for Postgraduates. 5th ed. New Delhi: Blackwell scientific publications; 1995;590-608.

Dowling EA, Gravlee LC. Endometrial cancer diagnosis: a new technique using a jet washer. Ala J Med Sci. 1964;1:412-6.

Fothergill DJ, Brown VA, Hill SA. Histological sampling of the endometrium- A comparison between formal curettage and the Pipelle sampler. Br J Obstet Gynaecol. 1992;99:779-80.

Fox CH, Turner FG, Johnson WL, Thornton NW. Endometrial cytology- A new technique. Am J Obst Gynec. 1962;83(12):1582-91.

Ginsberg NA, Padleckas R, Javaheri G. Diagnostic reliability of Mi-Mark helix technique in endometrial neoplasia. Obstet Gynecol. 1983;62(2):225-30.

Hecht EL. The endometrial aspiration smear; research status and clinical value. Am J Obst Gynec. 1956;71(4):819-33.

Isaacs J, Wilhoitte R. Aspiration cytology of the endometrium: office and hospital sampling procedures. Obstet Gynecol. 1974;118:679-87.

Jensen JG. Vacuum curettage, outpatient curettage without anesthesia: a report of 350 cases. Dan Med Bull. 1970;17:199-202.

Jordan MJ, Bader GM, Nemazie AS. Comparative accuracy of preoperative cytology and histologic diagnosis in endometrial lesions. Obst Gynec. 1956; 7:646-53.

J Abdulameer S. Cytogenetic Analysis of Children with Ambiguous Genitalia in Mosul. Rafidain J Sci. 2012;23(5):33-7.

Morton DG, MooreJG, Chang N. Endometrial lavage as an aid in the diagnosis of carcinoma of the endometrium. West J Surg Obstet Gynecol. 1957;65:113-9.






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