Experience of managing first fifty COVID-19 positive peripartum women in a tertiary care centre in North India

Authors

  • Vijay Zutshi Department of Obstetrics and Gynecology, VMMC and Safdarjung Hospital, New Delhi, India
  • Neha Mohit Bhagwati Department of Obstetrics and Gynecology, VMMC and Safdarjung Hospital, New Delhi, India http://orcid.org/0000-0002-9229-1153
  • Alka . Department of Obstetrics and Gynecology, VMMC and Safdarjung Hospital, New Delhi, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20210730

Keywords:

COVID-19, Corona virus, Maternal morbidity, Neonatal transmission, Pandemic

Abstract

Background: SARS-CoV-2 has caused significant morbidity and mortality worldwide. Analysis of the clinical profile of COVID-19 positive pregnant women is important to understand the pathophysiology, transmission and outcome of the disease in Indian population.

Methods: It is a retrospective observational study of first fifty pregnant patients tested positive for COVID-19 by qRT PCR admitted for delivery in our hospital.

Results: In this audit, first fifty COVID-19 pregnant women were studied and the mean age of the patients in this study was 26 years. 98% of these women were admitted for obstetric indications. Seventy two percent of these women were admitted with spontaneous onset of labour. Based on disease severity, 49 (98%) were either asymptomatic or exhibited mild disease and only 1 (2%) had severe disease who succumbed to her illness. Forty six percent patients delivered vaginally and 54% required cesarean delivery. The most common indication for LSCS was fetal distress (43%). Eighteen percent had preterm delivery. Among the newborn babies, one died due to severe birth asphyxia. Sixteen percent babies required NICU stay. Five babies tested positive for COVID-19 of which one baby was positive on day one of life.

Conclusions: As per our results, majority of the COVID-19 positive pregnant women had mild disease. There has been increase in cesarean section rate as compared to the previous hospital figures. Only one baby tested positive within 24 hours of delivery so the possibility vertical transmission can not be commented upon as of today.

Metrics

Metrics Loading ...

Author Biography

Neha Mohit Bhagwati, Department of Obstetrics and Gynecology, VMMC and Safdarjung Hospital, New Delhi, India

Fellow ( FNB) in high risk pregnancy and Perinatology in the department of obstetrics and Gynecology, VMMC & Safdarjung hospital.

References

Cascella M, Rajnik M, Cuomo A, et al. Features, Evaluation and Treatment Coronavirus (COVID-19). In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2020.

Max Roser, Hannah Ritchie, Esteban Ortiz-Ospina and Joe Hasell (2020) - "Coronavirus Pandemic (COVID-19)". Available at: OurWorldInData.org. https://ourworldindata.org/coronavirus'.

Coronaviridae Study Group of the International Committee on Taxonomy of Viruses. The Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol. 2020;5(4):536-44.

Su S, Wong G, Shi W, Liu J, Lai AC, Zhou J, et al. Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses. Trends Microbiol. 2016;24(6):490-502.

Luo Y, Yin K. Management of pregnant women infected with COVID-19. Lancet Infect Dis. 2020;20(5):513-4.

Wong SF, Chow KM, Leung TN, Ng WF, Ng TK, Shek CC, et al. Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome. Am J Obstet Gynecol. 2004;191(1):292-7.

Indian council of medical research. Revised Strategy for COVlD-19 testing in lndia. Available from: https://www.mohfw.gov.in/pdf/Revisedtestingguidelines.pdf. Accessed on 18 May 2020.

Government of India Ministry of Health and Family Welfare Directorate General of Health services (EMR division). Clinical Management Protocol for COVID-19. Available from: https://www.mohfw.gov.in/pdf/ClinicalManagementProtocolforCOVID19.pdf. Accessed 13 June 2020.

Noelle B, Caitlin B, Cynthia GB, Russell M, Rebecca M, Kyra B, et al. COVID-19 infection among asymptomatic and symptomatic pregnant women: Two weeks of confirmed presentations to an affiliated pair of New York City hospitals. Am J Obstet Gynecol MFM. 2020:100118.

Qiancheng X, Jian S, Lingling P, Lei H, Xiaogan J, Weihua L, et al. Coronavirus disease 2019 in pregnancy. Int J Infect Dis. 2020;95:376-83.

Zaigham M, Andersson O. Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies. Acta Obstet Gynecol Scand. 2020;99(7):823-9.

Yan J, Guo J, Fan C, Juan J, Yu X, Li J, et al. Coronavirus disease 2019 (COVID-19) in pregnant women: A report based on 116 cases. Am J Obstet Gynecol. 2020;223(1):111-e1.

Schwartz DA. An Analysis of 38 Pregnant Women with COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes. Arch Pathol Lab Med. 2020;144(7):799-805.

Mittal P, Pandey D, Suri J, Bharti R. Trend Prediction for Cesarean Deliveries Based on Robson Classification System at a Tertiary Referral Unit of North India. J Obstet Gynaecol India. 2020;70(2):111-8.

Chawanpaiboon S, Vogel JP, Moller AB, Lumbiganon P, Petzold M, Hogan D, et al. Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis. Lancet Glob Health. 2019;7(1):e37-e4.

Zeng L, Xia S, Yuan W, Yan K, Xiao F, Shao J, et al. Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China. JAMA pediatrics. 2020;174(7):722-5.

Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet Infec Dis. 2020;20(5):559-64.

Downloads

Published

2021-02-24

Issue

Section

Original Research Articles