Carcinoid tumor and papillary thyroid carcinoma arising from ovarian mature cystic teratoma: two cases of an extraordinary malignant transformation
Keywords:Carcinoid tumor, Malignant transformation of teratomas, Mature cystic teratoma, Papillary thyroid carcinoma
The most common malignant transformation of mature cystic teratoma of the ovary (MCTO) is squamous cell carcinoma, whereas, carcinoid tumor and papillary thyroid carcinoma are extremely extraordinary. This paper presents two rare cases of malignant transformation from MCTO. First, in a 33 year old, nulligravid, who underwent oophorocystectomy for a dermoid cyst. Histopathologic and Immunohistochemical studies revealed a carcinoid tumor arising from a mature cystic teratoma. Second, in a 52 year old who underwent, total abdominal hysterectomy with bilateral salpingo-oophorectomy for an ovarian new growth, with a final histopathologic and immunohistochemical analysis showed follicular variant of papillary carcinoma arising from mature cystic teratoma. Preoperative diagnosis of MCTO can be made through physical examination and imaging however not the concealed malignancy. Thorough extensive sampling and histopathologic examination of a dermoid cyst is necessary to detect malignant transformation. The optimal management of the disease is uncertain because of its rarity, but complete excision of tumor renders excellent prognosis.
Kim JY. A carcinoid tumor arising from a mature cystic teratoma in a 25-year-old patient: a case study, World J Surg Oncol. 2016;14:120.
Dane C, Ekmez M, Karaca A, Dane B. Case report of Follicular Variant of Papillary thyroid carcinoma arising from a dermoid cyst: A rare malignancy in a young women and review of literature. Taiwanese J Obstet Gynecol. 2012;51:421-5.
Souaf I, El Fatemi H, Bennani A. Papillary Carcinoma Derived from Ovarian Mature Cystic Teratoma: A New Case Report and Literature Review. Case Rep Clin Med. 2017;3:197-202.
Outwater E, Siegelman E, Hunt J. Ovarian Teratoma: Tumor types and imaging characteristics. Radio Graphics. 2001;21:475-79.
Park CH, Jung MH, Ji YI. Risk Factors for malignant transformation of mature cystic teratoma. Obstet Gynecol Sci. 2015;58(6):475-80.
Chun Y. Neuroendocrine Tumors of the Female Reproductive Tract: A Literature Review. J Pathol Transl Med. 2015;49(6):450-61.
Kamillaris C, Stratakis C. Multiple Endocrine Neoplasia Type 1 (MEN1): An Update and the Significance of Early Genetic and Clinical Diagnosis. Front Endocrinol (Lausanne) 2019;10:339.
Liu H, Lin F. Application of Immunohistochemistry in Thyroid Pathology. Arch Pathol Lab Med. 2015;139(1):67-82.
Guney N, Sayilgan T, Derin D, Ozcan D. Primary carcinoid tumor arising in a mature cystic teratoma of the ovary: a case report. Eur J Gynaecol Oncol. 2009;30(2):223-5.
Gainford MG, Tinker A, Carter J, Petru E, Nicklin J, et al. Malignant transformation within ovarian dermoid cysts: An audit of treatment reviewed and patient outcomes. An Australia New Zealand Gynecological Oncology Group (ANZGOG) and Gynecologic cancer Intergroup (CGIG) Study. Int J Gynecol Canc. 2010;20(1):75-81.