Laparoscopic ovarian drilling in clomiphene resistant polycystic ovarian syndrome: clinical response and outcome

Jesmine Banu; Shakeela Ishrat; Farzana Deeba; Chowdhury Faisal Alamgir; Maliha Darmoni; Nurjahan Begum; Shaheen Ara Anawary

doi:10.18203/2320-1770.ijrcog20213831

Authors

Jesmine Banu Department of Reproductive Endocrinology and Infertility BSMMU, Dhaka, Bangladesh
Shakeela Ishrat Department of Reproductive Endocrinology and Infertility BSMMU, Dhaka, Bangladesh
Farzana Deeba Department of Reproductive Endocrinology and Infertility BSMMU, Dhaka, Bangladesh
Chowdhury Faisal Alamgir Mymensingh Medical College and Hospital, Mymensingh, Bangladesh
Maliha Darmoni Mymensingh Medical College and Hospital, Mymensingh, Bangladesh
Nurjahan Begum Department of Reproductive Endocrinology and Infertility BSMMU, Dhaka, Bangladesh
Shaheen Ara Anawary Department of Reproductive Endocrinology and Infertility BSMMU, Dhaka, Bangladesh

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20213831

Keywords:

Laparoscopic, Ovarian drilling, Clomiphene resistant, PCOS

Abstract

Background: Laparoscopic ovarian drilling (LOD) is an alternative method for ovulation induction in clomiphene citrate (CC) resistant polycystic ovary syndrome (PCOS) patients instead of gonadotropins. Objective were to identify the changes in clinical and biochemical profiles and the ovulation and pregnancy rate following LOD in CC resistant PCOS patients.

Methods: It was an interventional study infertility unit, department of obstetrics and gynecology, Bangabandhu Sheikh Mujib medical university, Dhaka, between from July 2014 to June 2015. Changes of the above-mentioned parameters were recorded during follow up of patients after LOD. The information is collected and recorded in the preset questionnaire.

Results: The characteristics of study population were same before LOD and following LOD. Before LOD, infrequent menstruation was present in 83.3% patients whereas regular menstruation was found in 58.3% patients after 6 months following LOD. Endometrial thickness ≤8 was found in 100.0% in before LOD and endometrial thickness >8 was found in 70.0% after 6 month following LOD. Ovulation was found in 25.0% in after 3-month LOD and was found in 70.0% after 6 months following LOD. Pregnancy was found in 20.0% after 3 months following LOD and 50.0% in after 6 months following LOD. Ovulation and pregnancy outcome was significantly higher in after 6 months following LOD.

Conclusions: LOD produces long-term improvement in menstrual regularity and reproductive performance. A sustained improvement observed in acne and BMI. Ovulation and pregnancy were found in 70% and 50.0% respectively after 6 months following LOD.

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