Intrauterine insemination: a retrospective review on determinants of success
Keywords:
Infertility, IUI (intrauterine insemination), PregnancyAbstract
Background: To determine the prognostic factors such as female patient’s characteristics and of semen parameters on the pregnancy rate following intrauterine insemination
Methods: This study was done at Assisted Reproduction Centre, KLE’s Hospital and Medical Research Centre, Belgaum, India between June 2011 to May 2012. A total of 264 IUI cycles in which clomiphene citrate with or without human menopausal gonadotropin was used for ovarian stimulation were analysed retrospectively to identify prognostic factors regarding treatment outcome.
Results: In this study the pregnancy rate was 17.25%. The logistic regression analysis of variables showed that number of follicles and total IUI cycles were significantly associated with success rate but age of the couple, duration of infertility, endometrial thickness, size of the follicles, sperm count and sperm motility did not show significant differences between pregnant and non pregnant women.
Conclusions: The findings of this study showed that age of the couple, duration of infertility, endometrial thickness, size of the follicles, sperm count and sperm motility did not correlate with pregnancy occurrence in an IUI cycle but number of follicles and total IUI cycles correlated with the occurrence of pregnancy.
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References
Al-Shebly MM, Mansour MA. Evaluation of oxidative stress and antioxidant status in diabetic and hypertensive women during labor. Oxid Med Cell Longev. 2012;2012:329743.
Chamy V, Lepe J, Catalán A, Retamal D, Escobar J, Madrid E : Oxidative stress is closely related to clinical severity of pre-eclampsia, Biological Research 2006;39(2):229-36.
Agarwal A, Gupta S and Sharma R. Role of oxidative stress in female reproduction: Reproductive Biology and endocrinology 2005;vol.13 issue1, pages 28, 1122-49.
Gullmezoglu M, Hafmeyr G, Oosthuisen M : Antioxidants in the treatment of severe preeclamsia an explanatory randomized controlled trial : British Journal of Obstetrics and Gynecology, Jun 1997, Vol 104 Pg. 689-696.
Sharma J.B., Sharma A., Bahadur A., Vimala N., Satyam A., Mittal S. : Oxidative stress markers and antioxidant levels in normal pregnancy and preeclampsia,: International Journal of Gynecology and Obstetrics, 2006, 94, 23-27.
Sharma J. B., Mittal Suneeta : Prevention of Preeclampsia : Progress in obstetrics and Gynecology 2005; Vol 17; 141-163.
Ilhana N Ilhan N, Simsekc M : The changes of trace elements, malondialdehyde levels and superoxide dismutase activities in pregnancy with or without preeclampsia, Clinical Biochemistry : July 2002; 35 (5), pg 393-7.
Mahadik KV, Sina SA,: Study of serum levels of superoxide dismutase in preeclampsia and ecalmpsia : Role of the test as a predictive tool,: Research J Obstel Gynaecol, 2003 Aug:29(4):262-7.
Alice R., Rumbold A, Crowther C, Ross R., Dekker G A, and. Robinson S : Vitamin C and E and the risk of preeclampsia and perinatal complications : New England J. Med 2006; 354 : 1796-1806.
Desai P, Narayanan P : Role of Antioxidant Therapy to prevent Preeclampsia; Shah M :Hypertensive Disorders in Pregnancy : Jaypee Publisher New-Delhi India 2007 first Edition Pg. 293-298.
Wu JJ. Lipid peroxidation in preeclamptic and eclamptic pregnancies, European Journal obstetrics and gynecology and reproductive Biology, Jan 1996, vol 65, issue 1, pp 51-54.
Tug N, Celiu H, Ozcelik G.O, Ayar A.: T Tug N, Celiu H, Ozcelik G.O, Ayar A.: The correlation between plasma homocysteine and malondialdehyde levels in preeclampsia, Neuroendocrinology letter No. 6, Dec. 2003, Vol 24, pg. 445-448.
Mohanty S., Sahu P. K., Mandal M. K., Mohapatra P. C., Panda A. Evaluation of oxidative stress in pregnancy induced hypertension,: Indian Journal of clinical biochemistry, 2006, 21 (1) 101-105.
Suhail M, Suhail M. F, Khan H. Alterations in antioxidant and pro-oxidant balance in preeclampsia impact on erythrocyte osmotic fragility. Biochemia Medica 2008;18(3):331-41.
Mahadik KV, Sina SA. Study of serum levels of superoxide dismutase in preeclampsia and eclampsia: Role of the test as a predictive tool. Research J Obstet Gynaecol, 2003 Aug:29(4):262-7.
Chappell C, Paul S, Briley T, Annette L, Kelly F, Lee, Haunt R, Berverley J, Parmer K : Effect of antioxidant on occurrence of preeclampsia in women at increased risk; A randomized trial; The Lancet 1999; 354; 810-6.
Ghate J, Choudhari AR, Ghygare B. Singh Ramji. Antioxidant Role of Vitamin C in normal Pregnancy. Biomedical Research 2011;22(1):49-51.
