DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20211098

Age at menopause and the correlates of natural menopause among urban and rural women in the southern Nigeria

Eugene M. Ikeanyi, Ebenezer H. Ikobho

Abstract


Background: Menopause, the point in a woman’s life when permanent cessation of cyclical menstruation occurs for a period of 12 months due to the loss of ovarian activity marking the end of reproductive lifespan and potential. Natural menopause is a physiological event, universal women phenomenon and irreversible part of the entire normal aging process. It brings the menopausal woman for preventive health care services due to its associated health implications. This study sought to investigate the age at menopause and its correlates in southern Nigerian women.

Methods: A cross-sectional survey of datasets of women from two different communities attending annual religious conference was conducted using tested semi-structured researcher-administered questionnaire in 2019.

Results: Data was analyzed on 152 participants from an urban and a rural communities. Mean chronological age was 58.8±8.8 years and parity was 6.4±2.2. Mean age at menopause was 50.0±4.6 years, median (IQR) 50.0 (47-53) and 49.2±4.7 versus 50.5±4.5 and median (IQR) 49.5 (46-51) and 50.5 (47-54) for urban and rural participants respectively.  1.3%, 9.2%, 69.7% and 19.7% were premature, early, normal and late onset menopause respectively. Risk of early onset menopause was insignificantly increased by higher education, social class, lower BMI and low parity. Forgetfulness (20.3%), irritability (19.5%), hot flushes (17.3%) and insomnia (16.5%) were the leading symptoms. Main complications were chronic hypertension 62 (40.8%), diabetes mellitus 12 (7.9%) and 4 (2.6%) recent fractures.

Conclusions: Age at menopause was moderate, early menopause was rather high, programmed preventive healthcare services should address modifiable risk factors. Cancer screening services for late onset women is equally crucial.


Keywords


Age at natural menopause, Community, Correlates, Early, Factors, Survey

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References

Ellen B Gold The Timing of the Age at Which Natural Menopouse Occurs.Obstet Gynecol Clin North Am .2011;38(3):425-440.

Nicky Panay .Menopause and Postmenopausal Health In Dewhurst’s Textbook of Obstetrics and Gynaecology. D. Keith Edmonds, Christoph Lees,Tom Bourne eds. 9th Edition, ,Wiley Blackwell 2018; 672-688

Seung-Ah Choe, Joohon Sung Trends of Premature and Early Menopause: a Comparative Study of the US National Health and Nutrition Examination Survey and the Korea National Health and Nutrition Examination Survey. J Korean Med Sci 2020;35(14):e97

Mishra GD, Pandeya N, Dobson AJ, Chung HF, Anderson D, Kuh D, et al. Early menarche, nulliparity and the risk for premature and early natural menopause. Hum Reprod. 2017;32(3):679–686.

Committee Opinion. Primary Ovarian Insufficiency in Adolescents and Young Women. The American College of Obstetricians and Gynecologists Women’s Health Care Physicians 2014,Number 605

World Health Organization . Research on the menopause in the 1990s. World Health Organization; Geneva (Switzerland): 1996. [Google Scholar]

Cochran WG. Sampling techniques 3rd ed New York: John Wiley & Sons; 1977

OlaOlorun F,Lawoyin T Age at menopause and factors associated with attainment of menopause in an urban community in Ibadan,Nigeria J.Climacteric 2009;12(4): 352-63

Ozumba B.C, Obi S.N, Obikili E, Waboso P Age, symptoms and perception of menopause among Nigerian women. Obstet. Gynecol. Ind. 2004; 54(6):575-578.

Otolorin EO, Adeyefa I, Osotimehin BO,Fatinikun T,Ojengbede O,Otubu JO et al. Clinical, hormonal and biochemical features of menopausal women in Ibadan, Nigeria. Afr J Med Sci. 1989;18(4):251–5.

Okonofua, F.E, Lawal A, Bamgbose J.K. Features of menopause and menopausal age in Nigerian women. Int. J. Gynecol Obstet.1990; 31(4):341-345.

Ugwu UM, Umeora OUJ, Ejikeme BN Patterns of menopausal symptoms and adaptive ability in a rural population in South-east Nigeria J Obstet Gynae 2009;28(2):217-221

Gold E.B, Bromberger J, Crawford S, Samuels S, Greendale G.A, Harlow S.D, et al

Factors associated with age at natural menopause in a multiethnic sample of midlife women. Am. J.Epidemiol 2001; 153(9): 865-874.

Achie LN, Olorunshola KV, Mabrouk M Age at Natural Menopause among Nigerian Women in Zaria, Nigeria. Asian Journal of Medical Sciences 2011; 3(8): 151-153

Hardy R, Kuh D. Social and environmental conditions across the life course and age at menopause in a British birth cohort study. BJOG. 2005; 112:346–54.

Castelo-Branco C, Blümel JE, Chedraui P, Calle A, Bocanera R, Depiano E et al. Age at menopause in Latin America. Menopause. 2006;13(4):706–12. Erratum in: Menopause 2006;13:850.

Nichols HB, Trentham-Dietz A, Hampton JM, Titus-Ernstoff L, Egan KM, Willett WC, et al. From menarche to menopause: trends among US Women born from 1912 to 1969. Am J Epidemiol 2006;164(10):1003-11.

Agaba P, Meloni S, Sule H, Ocheke A, Agaba E, Idoko J, et al. Factors associated with early menopause among women in Nigeria. J Virus Erad 2017;3(3):145-51.

Calvet GA, Grinsztejn BG, Quintana Mde S, Alves MR, Veloso dos Santos VG, Friedman RK et al. Predictors of early menopause in HIV-infected women: a prospective cohort study. Am J Obstet Gynecol 2015; 212:765.e1–13.

Lawlor D.A, S. Ebrahim, G.D. Smith The association of socio-economic position across the life course and age at menopause: the British women’s heart and health. Br. J. Obstet. Gynecol. 2003; 110(12): 1078-1087.

Zhu D, Chung HF, Pandeya N, Dobson AJ, Kuh D, Crawford SL et al., “Body mass index and age at natural menopause: an international pooled analysis of 11prospective studies,” European Journal of Epidemiology, 2018; 33(8):699–710

Yanjun Wu, Wenjun Sun,Hui Liu, Dongfeng Zhang Age at Menopause and Risk of Developing Endometrial Cancer:A Meta-Analysis.Hindawi Biomed Resarch Int. 2019; ID 8584130, pp 1- 13

Soberon J, Calderon JJ, Goldzieher JW. Relation of parity to age at menopause. Am J Obstet Gynecol. 1966;96:96–100.

Ikeanyi Eugene Maduabuchukwu, Ibrahim Isa Ayuba Grandmultiparity: The Reasons Women Give for High Parity in South-South Nigeria Clinical Medicine Research 2017; 6(3): 92-98

Muka T, Oliver-Williams C, Kunutsor S, Laven JS, Fauser BC, Chowdhury R, et al Association of age at onset of menopause and time since onset of menopause with cardiovascular outcomes, intermediate vascular traits, and all-cause mortality: a systematic review and meta-analysis. JAMA cardiol 2016;1:767–776