Persistent genital arousal disorder: always look beyond the surface - a case report


  • Rita Sarabando Department of Obstetrics and Gynaecology, Hospital de Braga, Braga, Portugal
  • Natacha Sousa Department of Obstetrics and Gynaecology, Hospital de Braga, Braga, Portugal
  • Ana C. Borges Department of Obstetrics and Gynaecology, Hospital de Braga, Braga, Portugal
  • Cristina Nogueira-Silva Department of Obstetrics and Gynaecology, Hospital de Braga, Braga; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga; ICVS/3B's - PT Government Associate Laboratory, Braga/ Guimarães, Portugal



Persistent genital arousal disorder, Endometrial cancer, Malignancy


Persistent genital arousal disorder is a rare condition characterized by unwanted intrusive symptoms of sexual arousal without specific context. Their possible aetiologies and treatments are multiple and mostly based on case reports. We aim to do a comprehensive review of persistent genital arousal disorder and describe a case of a postmenopausal woman who developed this disease and, during the follow-up, was diagnosed with advanced endometrial cancer, reminding physicians to keep in mind the possibility of multiple diagnosis in the same patient, including malignancy. Although there is no description of this association in the literature, the possible aetiologies of persistent genital arousal disorder are diverse, and we sought this rare case should be disclosed.

Author Biography

Rita Sarabando, Department of Obstetrics and Gynaecology, Hospital de Braga, Braga, Portugal

Department of Obstetrics and Gynecology


Klifto KM, Dellon AL. Persistent genital arousal disorder: review of pertinent peripheral nerves. Sex Med Rev. 2020;8(2):265-73.

Jackowich RA, Pink L, Gordon A, Pukall. CF. Persistent genital arousal disorder: A review of its conceptualizations, potential origins, impact, and treatment. Sex Med Rev. 2016;4(4):329-42.

Pink L, Rancourt V, Gordon A. Persistent genital arousal in women with pelvic and genital pain. J Obstet Gynaecol Can. 2014;36(4):324-30.

Leiblum SR, Nathan SG. Persistent sexual arousal syndrome: a newly discovered pattern of female sexuality. J Sex Marital Ther. 2001;27(4):365-80.

Parish SJ, Goldstein AT, Goldstein SW, Goldstein I, Pfaus J, Clayton AH, et al. Toward a more evidence-based nosology and nomenclature for female sexual dysfunctions-part II. J Sex Med. 2016;13(12):1888-906.

McCabe MP, Sharlip ID, Atalla E, Balon R, Fisher AD, Laumann E, et al. Definitions of sexual dysfunctions in women and men: A consensus statement from the Fourth Consultation on Sexual Medicine 2015. J Sex Med. 2016;13(2):135-43.

Kruger THC. Can pharmacotherapy help persistent genital arousal disorder? Expert Opin Pharmacother. 2018;19(15):1705-9.

Waldinger MD, Venema PL, Gils APGV, Schweitzer DH. New insights into restless genital syndrome: static mechanical hyperesthesia and neuropathy of the nervus dorsalis clitoridis. J Sex Med. 2009;6(10):2778-87.

Facelle TM, Sadeghi-Nejad H, Goldmeier D. Persistent genital arousal disorder: characterization, etiology, and management. J Sex Med. 2013;10(2):439-50.

Amant F, Mirza MR, Koskas M, Creutzberg CL. Figo cancer report 2018: Cancer of the corpus uteri. Int J Gynecol Obstet. 2018;143(l2):37-50.






Case Reports