Surgical excision of frontal meningioma in pregnancy

Authors

  • Sumanjot Kaur Department of Obstetrics and Gynecology, PGIMER, Chandigarh, India
  • Manisha Meena Department of Obstetrics and Gynecology, PGIMER, Chandigarh, India
  • Pooja Sikka Department of Obstetrics and Gynecology, PGIMER, Chandigarh, India
  • Sushanta K. Sahoo Department of Neurosurgery, PGIMER, Chandigarh, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20263466

Keywords:

Meningioma, Craniotomy, Recurrent seizures

Abstract

We report a case of a pregnant woman at 33+3 weeks period of gestation presenting with recurrent seizure episodes without a background of hypertension. Neuroimaging revealed a well-defined extra-axial meningioma along the anterior falx in right frontal paramedian location. The patient underwent right frontal craniotomy with Simpson grade II excision with Caesarean delivery in same setting. A multidisciplinary team approach involving obstetricians, neurosurgery, and anesthesiology was employed to optimize maternal and fetal outcomes. Gross total resection of the tumour was achieved without intraoperative or postoperative complications. The patient showed resolution of neurological improvement postoperatively. Timely intervention and coordinated multidisciplinary care are essential to achieving favourable maternal and fetal outcomes.

Metrics

Metrics Loading ...

References

Lucy D, Pratima M, Puspa K, Umakant S, Niharika P. Pregnancy with meningioma. J Obstet Gynecol India. 2008;58(2):156-8.

Ettore C, Zambrotta E, Gulino FA, Incognito GG, Cannone FG, Ettore G. Meningioma in the third trimester of pregnancy: A case report. Case Reports in Women's Health. 2023;39:e00541. DOI: https://doi.org/10.1016/j.crwh.2023.e00541

Ostrom QT, Cioffi G, Gittleman H, Patil N, Waite K, Kruchko C, et al. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2012-2016. Neurooncol. 2019;21(5):v1-00. DOI: https://doi.org/10.1093/neuonc/noz150

Wiemels J, Wrensch M, Claus EB. Epidemiology and etiology of meningioma. J Neuro-oncol. 2010;99(3):307-14. DOI: https://doi.org/10.1007/s11060-010-0386-3

Bickerstaff ER, Small JM, Guest IA. The relapsing course of certain meningiomas in relation to pregnancy and menstruation. J Neurol Neurosurg Psychiat. 1958;21(2):89. DOI: https://doi.org/10.1136/jnnp.21.2.89

Roland N, Kolla E, Baricault B, Dayani P, Duranteau L, Froelich S, et al. Oral contraceptives with progestogens desogestrel or levonorgestrel and risk of intracranial meningioma: national case-control study. BMJ. 2025;389:e083981. DOI: https://doi.org/10.1136/bmj-2024-083981

Tettamanti G, Shu X, Mogensen H, Kopp Kallner H, Mathiesen T, Feychting M. Hormonal contraceptives and the risk of meningioma: A Swedish register-based case-control study. Neurooncology. 2026;28(2):552-61. DOI: https://doi.org/10.1093/neuonc/noaf228

Qi ZY, Shao C, Huang YL, Hui GZ, Zhou YX, Wang Z. Reproductive and exogenous hormone factors in relation to risk of meningioma in women: a meta-analysis. PloS one. 2013;8(12):e83261. DOI: https://doi.org/10.1371/journal.pone.0083261

Michaud DS, Gallo V, Schlehofer B, Tjønneland A, Olsen A, Overvad K, et al. Reproductive factors and exogenous hormone use in relation to risk of glioma and meningioma in a large European cohort study. Cancer Epidemiol Biomar Prevent. 2010;19(10):2562-9. DOI: https://doi.org/10.1158/1055-9965.EPI-10-0447

Yeap TB, Hamzah NA, Ismail MI, Ab Mukmin L. Neuroanaesthetic challenges in a pregnant patient with a huge cerebellopontine angle meningioma. BMJ Case Reports CP. 2023;16(5):e253694. DOI: https://doi.org/10.1136/bcr-2022-253694

Gurcay A, Bozkurt I, Senturk S, Kazanci A, Gurcan O, Turkoglu O, et al. Diagnosis, treatment, and management strategy of meningioma during pregnancy. Asian J Neurosurg. 2018;13(01):86-9. DOI: https://doi.org/10.4103/1793-5482.181115

Miyagishima DF, Sundaresan V, Gutierrez AG, Barak T, Yeung J, Moliterno J, et al. A systematic review and individual participant data meta-analysis of gonadal steroid hormone receptors in meningioma. J Neurosurg. 2023;139(6):1638-47. DOI: https://doi.org/10.3171/2023.3.JNS221838

El Abbassi I, Benaaguida H, Jalal M, Lamrissi A, Bouhya S. Cerebral meningioma during pregnancy mimicking eclampsia: About a rare case. Int J Surg Case Rep. 2023;111:108786. DOI: https://doi.org/10.1016/j.ijscr.2023.108786

Fagundes W, Sahin OK, Sabloak R, Silva YP, Dantas FL. Malignant Transformation of a Hormone Receptor-Positive Benign Intracranial Meningioma During Pregnancy: A Case Report. Cureus. 2025;17(11):1. DOI: https://doi.org/10.7759/cureus.97564

Pettersson-Segerlind J, Mathiesen T, Elmi-Terander A, Edström E, Talbäck M, Feychting M, et al. The risk of developing a meningioma during and after pregnancy. Scientific Rep. 2021;11(1):9153. DOI: https://doi.org/10.1038/s41598-021-88742-2

Ji Y, Rankin C, Grunberg S, Sherrod AE, Ahmadi J, Townsend JJ, et al. Double-blind phase III randomized trial of the antiprogestin agent mifepristone in the treatment of unresectable meningioma: SWOG S9005. J Clin Oncol. 2015;33(34):4093-8. DOI: https://doi.org/10.1200/JCO.2015.61.6490

Wen PY, Quant E, Drappatz J, Beroukhim R, Norden AD. Medical therapies for meningiomas. J Neuro-oncol. 2010;99(3):365-78. DOI: https://doi.org/10.1007/s11060-010-0349-8

Claus EB, Calvocoressi L, Bondy ML, Wrensch M, Wiemels JL, Schildkraut JM. Exogenous hormone use, reproductive factors, and risk of intracranial meningioma in females. J Neurosurg. 2013;118(3):649-56. DOI: https://doi.org/10.3171/2012.9.JNS12811

Custer B, Longstreth Jr WT, Phillips LE, Koepsell TD, Van Belle G. Hormonal exposures and the risk of intracranial meningioma in women: a population-based case-control study. BMC Cancer. 2006;6(1):152. DOI: https://doi.org/10.1186/1471-2407-6-152

Cossu G, Levivier M, Daniel RT, Messerer M. The role of mifepristone in meningiomas management: a systematic review of the literature. BioMed Res Int. 2015;2015(1):267831. DOI: https://doi.org/10.1155/2015/267831

Mwambegele R, Said H, Mwami P, Makundi R, Miranda A. Management of an intracranial meningioma in pregnancy in low resource setting: A case report and literature review. Int J Surg Case Rep. 2025;136:112047. DOI: https://doi.org/10.1016/j.ijscr.2025.112047

Roelvink NC, Kamphorst W, van Alphen HA, Rao BR. Pregnancy-related primary brain and spinal tumors. Arch Neurol. 1987;44(2):209-15. DOI: https://doi.org/10.1001/archneur.1987.00520140069020

Rodrigues AJ, Waldrop AR, Suharwardy S, Druzin ML, Iv M, Ansari JR, et al. Management of brain tumors presenting in pregnancy: a case series and systematic review. Am J Obstet Gynecol MFM. 2021;3(1):100256. DOI: https://doi.org/10.1016/j.ajogmf.2020.100256

Lusis EA, Scheithauer BW, Yachnis AT, Fischer BR, Chicoine MR, Paulus W, et al. Meningiomas in pregnancy: a clinicopathologic study of 17 cases. Neurosurgery. 2012;71(5):951-61. DOI: https://doi.org/10.1227/NEU.0b013e31826adf65

Beach RL, Kaplan PW. Seizures in pregnancy: diagnosis and management. Int Rev Neurobiol. 2008;83:259-71. DOI: https://doi.org/10.1016/S0074-7742(08)00015-9

Renukesh S, Rai L. Neurological disorders complicating pregnancy-focus on obstetric outcome. J Clin Diagnostic Res. 2016;10(12):QC06. DOI: https://doi.org/10.7860/JCDR/2016/19839.8955

Wahab M, Al-Azzawi F. Meningioma and hormonal influences. Climacteric. 2003;6(4):285-92. DOI: https://doi.org/10.1080/cmt.6.4.285.292

Cohen-Gadol AA, Friedman JA, Friedman JD, Tubbs RS, Munis JR, Meyer FB. Neurosurgical management of intracranial lesions in the pregnant patient: a 36-year institutional experience and review of the literature. J Neurosurg. 2009;111(6):1150-7. DOI: https://doi.org/10.3171/2009.3.JNS081160

Downloads

Published

2026-09-28

How to Cite

Kaur, S., Meena, M., Sikka, P., & Sahoo, S. K. (2026). Surgical excision of frontal meningioma in pregnancy. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 15(10), 4173–4176. https://doi.org/10.18203/2320-1770.ijrcog20263466

Issue

Section

Case Reports